Dissipative particle dynamics simulations of deformation and aggregation of healthy and diseased red blood cells in a tube flow

2014 ◽  
Vol 26 (11) ◽  
pp. 111902 ◽  
Author(s):  
Ting Ye ◽  
Nhan Phan-Thien ◽  
Boo Cheong Khoo ◽  
Chwee Teck Lim
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Dissipative Particle Dynamics ◽  
Particle Dynamics ◽  
Tube Flow ◽  
Dynamics Simulations

Multiscale Modeling of Flow Induced Thrombogenicity Using Dissipative Particle Dynamics and Molecular Dynamics

2013 ◽  
Author(s):  
Danny Bluestein ◽  
João S. Soares ◽  
Peng Zhang ◽  
Chao Gao ◽  
Seetha Pothapragada ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Blood Flow ◽  
Red Blood Cells ◽  
Platelet Activation ◽  
Blood Cells ◽  
Dissipative Particle Dynamics ◽  
Particle Dynamics ◽  
Coagulation Cascade ◽  
Shear Stresses ◽  
Activated Platelets

The coagulation cascade of blood may be initiated by flow induced platelet activation, which prompts clot formation in prosthetic cardiovascular devices and arterial disease processes. While platelet activation may be induced by biochemical agonists, shear stresses arising from pathological flow patterns enhance the propensity of platelets to activate and initiate the intrinsic pathway of coagulation, leading to thrombosis. Upon activation platelets undergo complex biochemical and morphological changes: organelles are centralized, membrane glycoproteins undergo conformational changes, and adhesive pseudopods are extended. Activated platelets polymerize fibrinogen into a fibrin network that enmeshes red blood cells. Activated platelets also cross-talk and aggregate to form thrombi. Current numerical simulations to model this complex process mostly treat blood as a continuum and solve the Navier-Stokes equations governing blood flow, coupled with diffusion-convection-reaction equations. It requires various complex constitutive relations or simplifying assumptions, and is limited to μm level scales. However, molecular mechanisms governing platelet shape change upon activation and their effect on rheological properties can be in the nm level scales. To address this challenge, a multiscale approach which departs from continuum approaches, may offer an effective means to bridge the gap between macroscopic flow and cellular scales. Molecular dynamics (MD) and dissipative particle dynamics (DPD) methods have been employed in recent years to simulate complex processes at the molecular scales, and various viscous fluids at low-to-high Reynolds numbers at mesoscopic scales. Such particle methods possess important properties at the mesoscopic scale: complex fluids with heterogeneous particles can be modeled, allowing the simulation of processes which are otherwise very difficult to solve by continuum approaches. It is becoming a powerful tool for simulating complex blood flow, red blood cells interactions, and platelet-mediated thrombosis involving platelet activation, aggregation, and adhesion.

ICCM2015(Paper ID:1148): DPD Simulation of the Movement and Deformation of Bioconcave Cells

2016 ◽  
Vol 13 (04) ◽  
pp. 1641003
Author(s):  
L. W. Zhou ◽  
Yu-Qian Zhang ◽  
Xiao-Long Deng ◽  
M. B. Liu
Keyword(s):  
Red Blood Cells ◽  
Poiseuille Flow ◽  
Blood Cells ◽  
Shear Flows ◽  
Dissipative Particle Dynamics ◽  
Particle Dynamics ◽  
Experimental Results ◽  
Shape Evolution ◽  
Movement And Deformation ◽  
Dpd Simulation

This paper presents a dissipative particle dynamics (DPDs) method for investigating the movement and deformation of biconcave shape red blood cells (RBCs) with the worm-like chain (WLC) bead spring. First, the stretching of a RBC is modeled and the obtained shape evolution of the cell agrees well with experimental results. Second, the movement and deformation of a RBC in shear flows are investigated and three typical modes (tumbling, intermittent and tank-treading) are observed. Lastly, an illustrating example of multi-RBCs in Poiseuille flow in a tube is simulated. We conclude that the presented DPD method with WLC spring can effectively model the movement and deformation of bioconcave cells.

scholarly journals GPU-accelerated red blood cells simulations with transport dissipative particle dynamics

2017 ◽  
Vol 217 ◽  
pp. 171-179 ◽  
Author(s):  
Ansel L. Blumers ◽  
Yu-Hang Tang ◽  
Zhen Li ◽  
Xuejin Li ◽  
George E. Karniadakis
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Dissipative Particle Dynamics ◽  
Particle Dynamics

Multiscale Modeling of Flow Induced Thrombogenicity With Dissipative Particle Dynamics (DPD) and Molecular Dynamics (MD)

2013 ◽  
Author(s):  
Danny Bluestein ◽  
João S. Soares ◽  
Peng Zhang ◽  
Chao Gao ◽  
Seetha Pothapragada ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Blood Flow ◽  
Red Blood Cells ◽  
Platelet Activation ◽  
Blood Cells ◽  
Dissipative Particle Dynamics ◽  
Particle Dynamics ◽  
Coagulation Cascade ◽  
Shear Stresses ◽  
Activated Platelets

The coagulation cascade of blood may be initiated by flow induced platelet activation, which prompts clot formation in prosthetic cardiovascular devices and arterial disease processes. While platelet activation may be induced by biochemical agonists, shear stresses arising from pathological flow patterns enhance the propensity of platelets to activate and initiate the intrinsic pathway of coagulation, leading to thrombosis. Upon activation platelets undergo complex biochemical and morphological changes: organelles are centralized, membrane glycoproteins undergo conformational changes, and adhesive pseudopods are extended. Activated platelets polymerize fibrinogen into a fibrin network that enmeshes red blood cells. Activated platelets also cross-talk and aggregate to form thrombi. Current numerical simulations to model this complex process mostly treat blood as a continuum and solve the Navier-Stokes equations governing blood flow, coupled with diffusion-convection-reaction equations. It requires various complex constitutive relations or simplifying assumptions, and is limited to μm level scales. However, molecular mechanisms governing platelet shape change upon activation and their effect on rheological properties can be in the nm level scales. To address this challenge, a multiscale approach which departs from continuum approaches, may offer an effective means to bridge the gap between macroscopic flow and cellular scales. Molecular dynamics (MD) and dissipative particle dynamics (DPD) methods have been employed in recent years to simulate complex processes at the molecular scales, and various viscous fluids at low-to-high Reynolds numbers at mesoscopic scales. Such particle methods possess important properties at the mesoscopic scale: complex fluids with heterogeneous particles can be modeled, allowing the simulation of processes which are otherwise very difficult to solve by continuum approaches. It is becoming a powerful tool for simulating complex blood flow, red blood cells interactions, and platelet-mediated thrombosis involving platelet activation, aggregation, and adhesion.

scholarly journals Two-Component Dissipative Particle Dynamics Model of Red Blood Cells

2014 ◽  
Vol 106 (2) ◽  
pp. 573a ◽  
Author(s):  
Zhangli Peng ◽  
Igor V. Pivkin ◽  
Xuejin Li ◽  
George E. Karniadakis ◽  
Ming Dao
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Dissipative Particle Dynamics ◽  
Particle Dynamics ◽  
Dynamics Model ◽  
Two Component
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