scholarly journals Scaffold architecture and fibrin gels promote meniscal cell proliferation

APL Materials ◽  
2015 ◽  
Vol 3 (1) ◽  
pp. 014901 ◽  
Author(s):  
K. M. Pawelec ◽  
S. M. Best ◽  
R. E. Cameron ◽  
R. J. Wardale
Keyword(s):  
Cell Proliferation ◽  
Fibrin Gels ◽  
Meniscal Cell ◽  
Scaffold Architecture

scholarly journals Bifunctional Aptamer Drug Carrier Enabling Selective and Efficient Incorporation of an Approved Anticancer Drug Irinotecan to Fibrin Gels

2020 ◽  
Vol 10 (23) ◽  
pp. 8755
Author(s):  
Hiroto Fujita ◽  
Yuka Kataoka ◽  
Masayasu Kuwahara
Keyword(s):  
Cell Proliferation ◽  
Drug Therapy ◽  
Anticancer Drug ◽  
Drug Carrier ◽  
Significant Inhibition ◽  
Tumor Cell Growth ◽  
Binding Properties ◽  
Fibrin Gels ◽  
Human Thrombin ◽  
Suppress Cell Proliferation

We have previously developed a bifunctional aptamer (bApt) binding to both human thrombin and camptothecin derivative (CPT1), and showed that bApt acts as a drug carrier under the phenomenon named selective oligonucleotide entrapment in fibrin polymers (SOEF), which enables efficient enrichment of CPT1 into fibrin gels, resulting in significant inhibition of tumor cell growth. However, although the derivative CPT1 exhibits anticancer activity, it is not an approved drug. In this study, we evaluated the binding properties of bApt to irinotecan, a camptothecin analog commonly used for anticancer drug therapy, in addition to unmodified camptothecin (CPT). Furthermore, we have revealed that irinotecan binds to bApt like CPT1 and is selectively concentrated on fibrin gels formed around the tumor cells under the SOEF phenomenon to suppress cell proliferation.

Silk–PVA Hybrid Nanofibrous Scaffolds for Enhanced Primary Human Meniscal Cell Proliferation

2016 ◽  
Vol 249 (6) ◽  
pp. 813-822 ◽  
Author(s):  
Mamatha M. Pillai ◽  
J. Gopinathan ◽  
B. Indumathi ◽  
Y. R. Manjoosha ◽  
K. Santosh Sahanand ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Meniscal Cell ◽  
Nanofibrous Scaffolds

Human Mesenchymal Stem Cell Proliferation and Osteogenic Differentiation in Fibrin Gels in Vitro

2006 ◽  
Vol 0 (0) ◽  
pp. 060802052515008
Author(s):  
Isabelle Catelas ◽  
Nadjah Sese ◽  
Benjamin M. Wu ◽  
James C.Y. Dunn ◽  
Sam Helgerson ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Osteogenic Differentiation ◽  
Human Mesenchymal Stem Cell ◽  
Fibrin Gels ◽  
Stem Cell Proliferation

Human Mesenchymal Stem Cell Proliferation and Osteogenic Differentiation in Fibrin Gels in Vitro

2006 ◽  
Vol 0 (0) ◽  
pp. 060802052515036 ◽  
Author(s):  
Isabelle Catelas ◽  
Nadjah Sese ◽  
Benjamin M. Wu ◽  
James C.Y. Dunn ◽  
Sam Helgerson ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Osteogenic Differentiation ◽  
Human Mesenchymal Stem Cell ◽  
Fibrin Gels ◽  
Stem Cell Proliferation

scholarly journals Induced-Coagulated Plasma-Fibrin Gels as a Biological Scaffold for Cell Attachment and Proliferation of Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSC)

2016 ◽  
Vol 19 (2) ◽  
pp. 159
Author(s):  
Rio Hermantara ◽  
Fiano A. Kerans ◽  
Rizal R ◽  
E. Henny Herningtyas ◽  
Lutfan Lazuardi
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Cell Proliferation ◽  
Umbilical Cord ◽  
Cell Attachment ◽  
Fibrinogen Concentration ◽  
Surface Markers ◽  
Culture Dish ◽  
Fibrin Gels ◽  
Biological Surface

Fibrin gels are an ideal natural biological scaffold for tissue engineering because they are biocompatible,biodegradable, and have many biological surface markers. However, most research on fi brin gels used commercialfi brin kits that could be costly and limited in some areas. In this study, fi brin gels were made by inducing bloodcoagulation by adding a common diagnostic kit to assess the time for blood to clot, called activated partialthromboplastin time (aPTT). This induced coagulated plasma (iCoplas)-fi brin gels was evaluated for its ability toenhance biological activity of umbilical cord-derived mesenchymal stem cell (UC-MSC), which were cell attachmentand proliferation. Fibrinogen concentration had infl uence on cell attachment, where only 50% of the cells couldattach to 77 mg/dl fi brinogen gels whereas 93% cells adhered to 154 mg/dl fi brin gels. There were no signifi cantdifferences in cell proliferation on polysterene culture dish and fi brin gels (p>0.05). These results showed thatiCoplas-fi brin gels could be used as a fi brin-based scaffold, yielding no signifi cant difference than polysterene-tissueculture dish cultures in cell attachment and cell proliferation on 154 mg/dl fi brinogen concentration.

Human Mesenchymal Stem Cell Proliferation and Osteogenic Differentiation in Fibrin Gels in Vitro

2006 ◽  
Vol 0 (0) ◽  
pp. 060706073730064 ◽  
Author(s):  
Isabelle Catelas ◽  
Nadjah Sese ◽  
Benjamin M. Wu ◽  
James C.Y. Dunn ◽  
Sam Helgerson ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Osteogenic Differentiation ◽  
Human Mesenchymal Stem Cell ◽  
Fibrin Gels ◽  
Stem Cell Proliferation

Egg shell membrane – a potential natural scaffold for human meniscal tissue engineering: an in vitro study

RSC Advances ◽  
2015 ◽  
Vol 5 (93) ◽  
pp. 76019-76025 ◽  
Author(s):  
Mamatha M. Pillai ◽  
T. R. Akshaya ◽  
V. Elakkiya ◽  
J. Gopinathan ◽  
K. Santosh Sahanand ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Proliferation ◽  
In Vitro Study ◽  
Vitro Study ◽  
Meniscal Cell ◽  
Shell Membrane ◽  
Meniscal Tissue ◽  
Egg Shell Membrane ◽  
Egg Shell

Enhanced human primary meniscal cell proliferation in autoclaved egg shell membrane.

Fibroblasts During Hypertrophic Scar Formation and Resolution

1973 ◽  
Vol 31 ◽  
pp. 428-429
Author(s):  
C. W. Kischer
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Cell Proliferation ◽  
Fine Structure ◽  
Metabolic Activity ◽  
Hypertrophic Scar ◽  
Normal Skin ◽  
Ground Substance ◽  
Hypertrophic Scars ◽  
Scanning Electron

The morphology of the fibroblasts changes markedly as the healing period from burn wounds progresses, through development of the hypertrophic scar, to resolution of the scar by a self-limiting process of maturation or therapeutic resolution. In addition, hypertrophic scars contain an increased cell proliferation largely made up of fibroblasts. This tremendous population of fibroblasts seems congruous with the abundance of collagen and ground substance. The fine structure of these cells should reflect some aspects of the metabolic activity necessary for production of the scar, and might presage the stage of maturation.A comparison of the fine structure of the fibroblasts from normal skin, different scar types, and granulation tissue has been made by transmission (TEM) and scanning electron microscopy (SEM).

The Effect of Androgen Depletion and Replacement on the Epithelium of the Seminal Vesicle of the Aging Rat

1975 ◽  
Vol 33 ◽  
pp. 590-591
Author(s):  
Venita F. Allison
Keyword(s):  
Cell Proliferation ◽  
Seminal Vesicle ◽  
Male Rats ◽  
Target Cells ◽  
Cell Regeneration ◽  
Secretory Function ◽  
Electron Microscopic ◽  
Aging Rat ◽  
Microscopic Studies ◽  
Androgen Depletion

In 1930, Moore, Hughes and Gallager reported that after castration seminal vesicle epithelial cell atrophy occurred and that cell regeneration could be achieved with daily injections of testis extract. Electron microscopic studies have confirmed those observations and have shown that testosterone injections restore the epithelium of the seminal vesicle in adult castrated male rats. Studies concerned with the metabolism of androgens point out that dihydrotestosterone stimulates cell proliferation and that other metabolites of testosterone probably influence secretory function in certain target cells.Although the influence of androgens on adult seminal vesicle epithelial cytology is well documented, little is known of the effect of androgen depletion and replacement on those cells in aging animals. The present study is concerned with the effect of castration and testosterone injection on the epithelium of the seminal vesicle of aging rats.

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