scholarly journals Migration and vascular lumen formation of endothelial cells in cancer cell spheroids of various sizes

2014 ◽  
Vol 8 (5) ◽  
pp. 052109 ◽  
Author(s):  
Bishnubrata Patra ◽  
Yu-Sheng Peng ◽  
Chien-Chung Peng ◽  
Wei-Hao Liao ◽  
Yu-An Chen ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cancer Cell ◽  
Lumen Formation ◽  
Vascular Lumen ◽  
Cell Spheroids

scholarly journals Molecular Mechanisms Controlling Vascular Lumen Formation in Three-Dimensional Extracellular Matrices

2012 ◽  
Vol 195 (1-2) ◽  
pp. 122-143 ◽  
Author(s):  
Anastasia Sacharidou ◽  
Amber N. Stratman ◽  
George E. Davis
Keyword(s):  
Molecular Mechanisms ◽  
Three Dimensional ◽  
Extracellular Matrices ◽  
Lumen Formation ◽  
Vascular Lumen

scholarly journals Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2–mediated heparin-binding EGF signaling in endothelial cells

2011 ◽  
Vol 108 (32) ◽  
pp. 13147-13152 ◽  
Author(s):  
Katrin J. Svensson ◽  
Paulina Kucharzewska ◽  
Helena C. Christianson ◽  
Stefan Sköld ◽  
Tobias Löfstedt ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cancer Cell ◽  
Heparin Binding ◽  
Egf Signaling

scholarly journals Vascular Lumen Formation: Negativity Will Tear Us Apart

2010 ◽  
Vol 20 (22) ◽  
pp. R973-R975 ◽  
Author(s):  
Renée M. Robbins ◽  
Greg J. Beitel
Keyword(s):  
Lumen Formation ◽  
Vascular Lumen

Endothelial cells promote triple‐negative breast cancer cell metastasis via PAI‐1 and CCL5 signaling

2017 ◽  
Vol 32 (1) ◽  
pp. 276-288 ◽  
Author(s):  
Wenwen Zhang ◽  
Jing Xu ◽  
Hehui Fang ◽  
Lin Tang ◽  
Weiwei Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endothelial Cells ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cell Metastasis ◽  
Pai 1

scholarly journals Multiple endothelial cells constitute the tip of developing blood vessels and polarize to promote lumen formation

Development ◽  
2014 ◽  
Vol 141 (21) ◽  
pp. 4121-4126 ◽  
Author(s):  
J. C. Pelton ◽  
C. E. Wright ◽  
M. Leitges ◽  
V. L. Bautch
Keyword(s):  
Endothelial Cells ◽  
Blood Vessels ◽  
Lumen Formation

scholarly journals Exosomal Thrombospondin-1 Disrupts the Integrity of Endothelial Intercellular Junctions to Facilitate Breast Cancer Cell Metastasis

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1946 ◽  
Author(s):  
Junyu Cen ◽  
Lingyun Feng ◽  
Huichuan Ke ◽  
Lifeng Bao ◽  
Lin Z. Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endothelial Cells ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cells ◽  
Transendothelial Migration ◽  
Intercellular Junction ◽  
Malignant Cells ◽  
Junction Proteins

Transendothelial migration of malignant cells plays an essential role in tumor progression and metastasis. The present study revealed that treating human umbilical vein endothelial cells (HUVECs) with exosomes derived from metastatic breast cancer cells increased the number of cancer cells migrating through the endothelial cell layer and impaired the tube formation of HUVECs. Furthermore, the expression of intercellular junction proteins, including vascular endothelial cadherin (VE-cadherin) and zona occluden-1 (ZO-1), was reduced significantly in HUVECs treated with carcinoma-derived exosomes. Proteomic analyses revealed that thrombospondin-1 (TSP1) was highly expressed in breast cancer cell MDA-MB-231-derived exosomes. Treating HUVECs with TSP1-enriched exosomes similarly promoted the transendothelial migration of malignant cells and decreased the expression of intercellular junction proteins. TSP1-down regulation abolished the effects of exosomes on HUVECs. The migration of breast cancer cells was markedly increased in a zebrafish in vivo model injected with TSP1-overexpressing breast cancer cells. Taken together, these results suggest that carcinoma-derived exosomal TSP1 facilitated the transendothelial migration of breast cancer cells via disrupting the intercellular integrity of endothelial cells.

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