Amplification of interference color by using liquid crystal for protein detection

2013 ◽  
Vol 103 (24) ◽  
pp. 243701 ◽  
Author(s):  
Qingdi Zhu ◽  
Kun-Lin Yang
Keyword(s):  
Liquid Crystal ◽  
Protein Detection ◽  
Interference Color

Liquid crystal droplets functionalized with charged surfactant and polyelectrolyte for non-specific protein detection

RSC Advances ◽  
2015 ◽  
Vol 5 (118) ◽  
pp. 97264-97271 ◽  
Author(s):  
Lei Yang ◽  
Mashooq Khan ◽  
Soo-Young Park
Keyword(s):  
Liquid Crystal ◽  
Protein Detection ◽  
Specific Protein

5CBsurfactant droplets were coated with polyelectrolytes for utilization of non-specific protein detection.

scholarly journals A Single-Substrate Biosensor with Spin-Coated Liquid Crystal Film for Simple, Sensitive and Label-Free Protein Detection

Biosensors ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 374
Author(s):  
Po-Chang Wu ◽  
Chao-Ping Pai ◽  
Mon-Juan Lee ◽  
Wei Lee
Keyword(s):  
Liquid Crystal ◽  
Film Thickness ◽  
Limit Of Detection ◽  
Protein Detection ◽  
Cost Effective ◽  
Antibody Concentration ◽  
Label Free ◽  
Free Protein ◽  
Single Substrate ◽  
Simplified Procedure

A liquid crystal (LC)-based single-substrate biosensor was developed by spin-coating an LC thin film on a dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride (DMOAP)-decorated glass slide. Compared with the conventional sandwiched cell configuration, the simplified procedure for the preparation of an LC film allows the film thickness to be precisely controlled by adjusting the spin rate, thus eliminating personal errors involved in LC cell assembly. The limit of detection (LOD) for bovine serum albumin (BSA) was lowered from 10−5 g/mL with a 4.2-μm-thick sandwiched cell of the commercial LC E7 to 10−7 g/mL with a 4.2-μm-thick spin-coated E7 film and further to 10−8 g/mL by reducing the E7 film thickness to 3.4 μm. Moreover, by exploiting the LC film of the highly birefringent nematic LC HDN in the immunodetection of the cancer biomarker CA125, an LOD comparable to that determined with a sandwiched HDN cell was achieved at 10−8 g/mL CA125 using a capture antibody concentration an order of magnitude lower than that in the LC cell. Our results suggest that employing spin-coated LC film instead of conventional sandwiched LC cell provides a more reliable, reproducible, and cost-effective single-substrate platform, allowing simple fabrication of an LC-based biosensor for sensitive and label-free protein detection and immunoassay.

Freeze-fracture TEM of the helical smectic A* phase

1992 ◽  
Vol 50 (1) ◽  
pp. 278-279
Author(s):  
K.J. Ihn ◽  
R. Pindak ◽  
J. A. N. Zasadzinski
Keyword(s):  
Liquid Crystal ◽  
Grain Boundary ◽  
Grain Boundaries ◽  
Freeze Fracture ◽  
Smectic Phase ◽  
Layer Spacing ◽  
Screw Dislocations ◽  
Smectic A ◽  
Smectic Phases ◽  
Discrete Amount

A new liquid crystal (called the smectic-A* phase) that combines cholesteric twist and smectic layering was a surprise as smectic phases preclude twist distortions. However, the twist grain boundary (TGB) model of Renn and Lubensky predicted a defect-mediated smectic phase that incorporates cholesteric twist by a lattice of screw dislocations. The TGB model for the liquid crystal analog of the Abrikosov phase of superconductors consists of regularly spaced grain boundaries of screw dislocations, parallel to each other within the grain boundary, but rotated by a fixed angle with respect to adjacent grain boundaries. The dislocations divide the layers into blocks which rotate by a discrete amount, Δθ, given by the ratio of the layer spacing, d, to the distance between grain boundaries, lb; Δθ ≈ d/lb (Fig. 1).

Attractive mode force microscopy of chiral liquid crystal surfaces

1992 ◽  
Vol 50 (1) ◽  
pp. 268-269
Author(s):  
B.D. Terris ◽  
R. J. Twieg ◽  
C. Nguyen ◽  
G. Sigaud ◽  
H. T. Nguyen
Keyword(s):  
Liquid Crystal ◽  
Crystal Surfaces ◽  
Free Surfaces ◽  
Control Range ◽  
Force Microscopy ◽  
Liquid Crystal Films ◽  
Chiral Liquid Crystal ◽  
Crystal Films ◽  
Electrostatic Charging ◽  
And Shifts

We have used a force microscope in the attractive, or noncontact, mode to image a variety of surfaces. In this mode, the microscope tip is oscillated near its resonant frequency and shifts in this frequency due to changes in the surface-tip force gradient are detected. We have used this technique in a variety of applications to polymers, including electrostatic charging, phase separation of ionomer surfaces, and crazing of glassy films.Most recently, we have applied the force microscope to imaging the free surfaces of chiral liquid crystal films. The compounds used (Table 1) have been chosen for their polymorphic variety of fluid mesophases, all of which exist within the temperature control range of our force microscope.

Development of liquid crystal light valves using Bi12SiO20 as the photoconductor. Part 2: Device performance

1986 ◽  
Vol 133 (1) ◽  
pp. 65
Author(s):  
W.L. Baillie ◽  
P.M. Openshaw ◽  
A.D. Hart ◽  
S.S. Makh
Keyword(s):  
Liquid Crystal ◽  
Device Performance
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