Label-free detection of cardiac troponin-I using gold nanoparticles functionalized single-walled carbon nanotubes based chemiresistive biosensor

2013 ◽  
Vol 103 (20) ◽  
pp. 203703 ◽  
Author(s):  
Rajesh ◽  
Vikash Sharma ◽  
Nitin K. Puri ◽  
Rajiv K. Singh ◽  
Ashok M. Biradar ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Gold Nanoparticles ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Single Walled Carbon Nanotubes ◽  
Cardiac Troponin I ◽  
Label Free ◽  
Single Walled Carbon ◽  
Label Free Detection ◽  
Walled Carbon Nanotubes

Doping and plasmonic Raman enhancement in hybrid single walled carbon nanotubes films with embedded gold nanoparticles

Carbon ◽  
2021 ◽  
Vol 179 ◽  
pp. 531-540
Author(s):  
Anna Wroblewska ◽  
Georgy Gordeev ◽  
Anna Duzynska ◽  
Stephanie Reich ◽  
Mariusz Zdrojek
Keyword(s):  
Carbon Nanotubes ◽  
Gold Nanoparticles ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Raman Enhancement ◽  
Walled Carbon Nanotubes

scholarly journals Long-Range Surface Plasmon-Polariton Waveguide Biosensors for Human Cardiac Troponin I Detection

Sensors ◽  
2019 ◽  
Vol 19 (3) ◽  
pp. 631 ◽  
Author(s):  
Oleksiy Krupin ◽  
Pierre Berini
Keyword(s):  
Long Range ◽  
Surface Plasmon ◽  
Cardiac Troponin ◽  
Surface Plasmon Polariton ◽  
Troponin I ◽  
Biological Marker ◽  
Cardiac Troponin I ◽  
Label Free ◽  
Label Free Detection ◽  
Plasmon Polariton

Straight long-range surface plasmon-polariton (LRSPP) waveguides as biosensors for label-free detection are discussed. The sensors consist of 5-μm-wide 35-nm-thick gold stripes embedded in a low-index optical-grade fluoropolymer (CYTOPTM) with fluidic channels etched to the Au surface of the stripes. This work demonstrates the application of the LRSPP biosensors for the detection of human cardiac troponin I (cTnI) protein. cTnI is a biological marker for acute myocardial infarction (AMI), often referred to as a heart attack, which can be diagnosed by elevated levels of cTnI in patient blood. Direct and sandwich assays were developed and demonstrated over the concentration range from 1 to 1000 ng/mL, yielding detection limits of 430 pg/mL for the direct assay and 28 pg/mL for the sandwich assay (1 standard deviation), the latter being physiologically relevant to the early detection or onset of AMI. In addition, a novel approach for data analysis is proposed, where the analyte response is normalized to the response of the antibody layer.

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