scholarly journals On the influence of the architecture of poly(ethylene glycol)-based thermoresponsive polymers on cell adhesion

2012 ◽  
Vol 6 (2) ◽  
pp. 024129 ◽  
Author(s):  
Katja Uhlig ◽  
Björn Boysen ◽  
Andreas Lankenau ◽  
Magnus Jaeger ◽  
Erik Wischerhoff ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Thermoresponsive Polymers ◽  
Poly Ethylene

scholarly journals Methoxy-Poly(ethylene glycol) Modified Poly(L-lactide) Enhanced Cell Affinity of Human Bone Marrow Stromal Cells by the Upregulation of 1-Cadherin and Delta-2-catenin

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Xueli Mao ◽  
Zetao Chen ◽  
Junqi Ling ◽  
Jingjing Quan ◽  
Hui Peng ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Adhesion ◽  
Ethylene Glycol ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Poly Ethylene Glycol ◽  
Copolymer Films ◽  
Cell Affinity ◽  
Poly Ethylene

Poly(l-lactide) (PLLA), a versatile biodegradable polymer, is one of the most commonly-used materials for tissue engineering applications. To improve cell affinity for PLLA, poly(ethylene glycol) (PEG) was used to develop diblock copolymers. Human bone marrow stromal cells (hBMSCs) were cultured on MPEG-b-PLLA copolymer films to determine the effects of modification on the attachment and proliferation of hBMSC. The mRNA expression of 84 human extracellular matrix (ECM) and adhesion molecules was analyzed using RT-qPCR to understand the underlying mechanisms. It was found that MPEG-b-PLLA copolymer films significantly improved cell adhesion, extension, and proliferation. This was found to be related to the significant upregulation of two adhesion genes, CDH1 and CTNND2, which encode 1-cadherin and delta-2-catenin, respectively, two key components for the cadherin-catenin complex. In summary, MPEG-b-PLLA copolymer surfaces improved initial cell adhesion by stimulation of adhesion molecule gene expression.

scholarly journals Functionalized Poly(ethylene glycol)-Based Bioassay Surface Chemistry That Facilitates Bio-Immobilization and Inhibits Nonspecific Protein, Bacterial, and Mammalian Cell Adhesion

2007 ◽  
Vol 19 (18) ◽  
pp. 4405-4414 ◽  
Author(s):  
Gregory M. Harbers ◽  
Kazunori Emoto ◽  
Charles Greef ◽  
Steven W. Metzger ◽  
Heather N. Woodward ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Ethylene Glycol ◽  
Surface Chemistry ◽  
Mammalian Cell ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Local Toxicity of Topically Administrated Thermoresponsive Systems: In Vitro Studies with In Vivo Correlation

2018 ◽  
Vol 47 (3) ◽  
pp. 426-432 ◽  
Author(s):  
Sivan Yogev ◽  
Ayelet Shabtay-Orbach ◽  
Abraham Nyska ◽  
Boaz Mizrahi
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Medical Devices ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Thermoresponsive Polymers ◽  
Wide Range ◽  
Poly Ethylene

Thermoresponsive materials have the ability to respond to a small change in temperature—a property that makes them useful in a wide range of applications and medical devices. Although very promising, there is only little conclusive data about the cytotoxicity and tissue toxicity of these materials. This work studied the biocompatibility of three Food and Drug Administration approved thermoresponsive polymers: poly( N-isopropyl acrylamide), poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) tri-block copolymer, and poly(lactic acid-co-glycolic acid) and poly(ethylene glycol) tri-block copolymer. Fibroblast NIH 3T3 and HaCaT keratinocyte cells were used for the cytotoxicity testing and a mouse model for the in vivo evaluation. In vivo results generally showed similar trends as the results seen in vitro, with all tested materials presenting a satisfactory biocompatibility in vivo. pNIPAM, however, showed the highest toxicity both in vitro and in vivo, which was explained by the release of harmful monomers and impurities. More data focusing on the biocompatibility of novel thermoresponsive biomaterials will facilitate the use of existing and future medical devices.

Effect of poly(ethylene glycol) graft polymerization of poly(methyl methacrylate) on cell adhesion

2001 ◽  
Vol 27 (5) ◽  
pp. 766-774 ◽  
Author(s):  
Mee Kum Kim ◽  
In Suk Park ◽  
Hyung Dal Park ◽  
Won Ryang Wee ◽  
Jin Hak Lee ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Ethylene Glycol ◽  
Methyl Methacrylate ◽  
Graft Polymerization ◽  
Poly Ethylene Glycol ◽  
Poly Methyl Methacrylate ◽  
Poly Ethylene

Phase Transition Behavior, Protein Adsorption, and Cell Adhesion Resistance of Poly(ethylene glycol) Cross-Linked Microgel Particles

2005 ◽  
Vol 6 (4) ◽  
pp. 2032-2039 ◽  
Author(s):  
Christine M. Nolan ◽  
Catherine D. Reyes ◽  
Justin D. Debord ◽  
Andrés J. García ◽  
L. Andrew Lyon
Keyword(s):  
Phase Transition ◽  
Cell Adhesion ◽  
Ethylene Glycol ◽  
Protein Adsorption ◽  
Poly Ethylene Glycol ◽  
Phase Transition Behavior ◽  
Transition Behavior ◽  
Microgel Particles ◽  
Poly Ethylene

Photocontrol of cell adhesion on amino-bearing surfaces by reversible conjugation of poly(ethylene glycol) via a photocleavable linker

2011 ◽  
Vol 13 (9) ◽  
pp. 4051 ◽  
Author(s):  
Shingo Kaneko ◽  
Hidekazu Nakayama ◽  
Yutaro Yoshino ◽  
Daisuke Fushimi ◽  
Kazuo Yamaguchi ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Construction of a Tethered Poly(ethylene glycol) Surface Gradient For Studies of Cell Adhesion Kinetics

Langmuir ◽  
2005 ◽  
Vol 21 (11) ◽  
pp. 4809-4812 ◽  
Author(s):  
K. Mougin ◽  
A. S. Ham ◽  
M. B. Lawrence ◽  
E. J. Fernandez ◽  
A. C. Hillier
Keyword(s):  
Cell Adhesion ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Surface Gradient ◽  
Poly Ethylene
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