Equilibrium conformations and dynamic relaxation of double‐tethered chain molecules at an impenetrable interface

1996 ◽  
Vol 105 (17) ◽  
pp. 7712-7722 ◽  
Author(s):  
Harpreet S. Gulati ◽  
Carol K. Hall ◽  
Ronald L. Jones ◽  
Richard J. Spontak
Keyword(s):  
Dynamic Relaxation ◽  
Chain Molecules ◽  
Tethered Chain

scholarly journals Transitions of tethered chain molecules under tension

2014 ◽  
Vol 141 (11) ◽  
pp. 114911 ◽  
Author(s):  
Jutta Luettmer-Strathmann ◽  
Kurt Binder
Keyword(s):  
Chain Molecules ◽  
Tethered Chain

scholarly journals Changes in the structure of tethered chain molecules as predicted by density functional approach

2011 ◽  
Vol 14 (3) ◽  
pp. 33604 ◽  
Author(s):  
Borówko ◽  
Patrykiejew ◽  
Pizio ◽  
Sokołowski
Keyword(s):  
Density Functional ◽  
Functional Approach ◽  
Chain Molecules ◽  
Tethered Chain

Thermodynamic calculations of linear chain molecules using a SAFT model

2001 ◽  
Vol 99 (1) ◽  
pp. 65-76 ◽  
Author(s):  
Yiping Tang, Zhaohui Wang, Benjamin C.-Y.
Keyword(s):  
Linear Chain ◽  
Thermodynamic Calculations ◽  
Chain Molecules

Chemical potential and dimensions of chain molecules in athermal environments

1996 ◽  
Vol 89 (6) ◽  
pp. 1733-1754 ◽  
Author(s):  
FERNANDO ESCOBEDO ◽  
JUAN DE PABLO
Keyword(s):  
Chemical Potential ◽  
Chain Molecules

Inhibition in Purified Systems and in Human Plasma of Chimaeric Plasminogen Activators Consisting of the NH2-Terminal Region of Tissue-Type Plasminogen Activator and the COOH-Terminal Region of UrokinaseType Plasminogen Activator

1988 ◽  
Vol 60 (02) ◽  
pp. 247-250 ◽  
Author(s):  
H R Lijnen ◽  
L Nelles ◽  
B Van Hoef ◽  
F De Cock ◽  
D Collen
Keyword(s):  
Plasminogen Activator ◽  
Rate Constants ◽  
Plasminogen Activators ◽  
Second Order ◽  
Tissue Type ◽  
Single Chain ◽  
Chain Molecules ◽  
Order Rate ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator

SummaryRecombinant chimaeric molecules between tissue-type plasminogen activator (t-PA) and single chain urokinase-type plasminogen activator (scu-PA) or two chain urokinase-type plasminogen activator (tcu-PA) have intact enzymatic properties of scu-PA or tcu-PA towards natural and synthetic substrates (Nelles et al., J Biol Chem 1987; 262: 10855-10862). In the present study, we have compared the reactivity with inhibitors of both the single chain and two chain variants of recombinant u-PA and two recombinant chimaeric molecules between t-PA and scu-PA (t-PA/u-PA-s: amino acids 1-263 of t-PA and 144-411 of u-PA; t-PA/u-PA-e: amino acids 1-274 of t-PA and 138-411 of u-PA). Incubation with human plasma in the absence of a fibrin clot for 3 h at 37° C at equipotent concentrations (50% clot lysis in 2 h), resulted in significant fibrinogen breakdown (to about 40% of the normal value) for all two chain molecules, but not for their single chain counterparts. Preincubation of the plasminogen activators with plasma for 3 h at 37° C, resulted in complete inhibition of the fibrinolytic potency of the two chain molecules but did not alter the potency of the single chain molecules. Inhibition of the two chain molecules occurred with a t½ of approximately 45 min. The two chain variants were inhibited by the synthetic urokinase inhibitor Glu-Gly-Arg-CH2CCl with apparent second-order rate constants of 8,000-10,000 M−1s−1, by purified α2-antiplasmin with second-order rate constants of about 300 M−1s−1, and by plasminogen activator inhibitor-1 (PAI-1) with second-order rate constants of approximately 2 × 107 M−1s−1.It is concluded that the reactivity of single chain and two chain forms of t-PA/u-PA chimaers with inhibitors is very similar to that of the single and two chain forms of intact u-PA.

scholarly journals Activity of the first interstellar comet 2I/Borisov around perihelion: results from Indian observatories

2021 ◽  
Vol 502 (3) ◽  
pp. 3491-3499
Author(s):  
K Aravind ◽  
Shashikiran Ganesh ◽  
Kumar Venkataramani ◽  
Devendra Sahu ◽  
Dorje Angchuk ◽  
...  
Keyword(s):  
Solar System ◽  
Production Rate ◽  
Rate Ratio ◽  
Carbon Chain ◽  
Astronomical Observatory ◽  
Nucleus Size ◽  
Chain Molecules ◽  
Molecular Emission ◽  
Imaging And Spectroscopy ◽  
Gas Ratio

ABSTRACT Comet 2I/Borisov is the first true interstellar comet discovered. Here, we present results from observational programs at two Indian observatories, 2 m Himalayan Chandra Telescope at the Indian Astronomical Observatory, Hanle (HCT) and 1.2 m telescope at the Mount Abu Infrared Observatory (MIRO). Two epochs of imaging and spectroscopy were carried out at the HCT and three epochs of imaging at MIRO. We found CN to be the dominant molecular emission on both epochs, 2019 November 30 and December 22, at distances of rH = 2.013 and 2.031 au, respectively. The comet was inferred to be relatively depleted in Carbon bearing molecules on the basis of low C2 and C3 abundances. We find the production rate ratio, Q(C2)/Q(CN) = 0.54 ± 0.18, pre-perihelion and Q(C2)/Q(CN) = 0.34 ± 0.12 post-perihelion. This classifies the comet as being moderately depleted in carbon chain molecules. Using the results from spectroscopic observations, we believe the comet to have a chemically heterogeneous surface having variation in abundance of carbon chain molecules. From imaging observations, we infer a dust-to-gas ratio similar to carbon chain depleted comets of the Solar system. We also compute the nucleus size to be in the range 0.18 km ≤ r ≤ 3.1 km. Our observations show that 2I/Borisov’s behaviour is analogous to that of the Solar system comets.

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