Rotational diffusion of rose bengal

Arvind Srivastava; S. Doraiswamy

doi:10.1063/1.470447

Rotational diffusion of rose bengal in aqueous micelles: evidence for extensive exposure of the hydrocarbon chains

Journal of the American Chemical Society ◽

10.1021/ja00405a056 ◽

1981 ◽

Vol 103 (15) ◽

pp. 4591-4593 ◽

Cited By ~ 22

Author(s):

Wayne Reed ◽

Mario J. Politi ◽

Janos H. Fendler

Keyword(s):

Rose Bengal ◽

Rotational Diffusion ◽

Hydrocarbon Chains ◽

Aqueous Micelles

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ChemInform Abstract: ROTATIONAL DIFFUSION OF ROSE BENGAL IN AQUEOUS MICELLES: EVIDENCE FOR EXTENSIVE EXPOSURE OF THE HYDROCARBON CHAINS

Chemischer Informationsdienst ◽

10.1002/chin.198144068 ◽

1981 ◽

Vol 12 (44) ◽

Author(s):

W. REED ◽

M. J. POLITI ◽

J. H. FENDLER

Keyword(s):

Rose Bengal ◽

Rotational Diffusion ◽

Hydrocarbon Chains ◽

Aqueous Micelles

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Investigation of the rotational diffusion of the Rose Bengal fluorescent nanomarker in human serum albumin solutions

Moscow University Physics Bulletin ◽

10.3103/s0027134913030119 ◽

2013 ◽

Vol 68 (3) ◽

pp. 231-234 ◽

Cited By ~ 3

Author(s):

I. M. Vlasova ◽

D. V. Polynskii ◽

A. A. Vlasov ◽

A. M. Saletsky

Keyword(s):

Human Serum Albumin ◽

Serum Albumin ◽

Human Serum ◽

Rose Bengal ◽

Rotational Diffusion ◽

The Rose

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Surgical vs nonsurgical jaundice. Differentiation by a combination of rose bengal I-131 and standard liver-function tests

JAMA ◽

10.1001/jama.194.9.949 ◽

1965 ◽

Vol 194 (9) ◽

pp. 949-953 ◽

Cited By ~ 6

Author(s):

R. A. Nordyke

Keyword(s):

Liver Function ◽

Rose Bengal ◽

Liver Function Tests ◽

Function Tests

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On the applicability of the rotational diffusion model in liquid crystalline solvents. A nuclear magnetic relaxation study of toluene

Journal de Physique ◽

10.1051/jphys:0199000510220258100 ◽

1990 ◽

Vol 51 (22) ◽

pp. 2581-2593 ◽

Cited By ~ 16

Author(s):

J. Bulthuis ◽

L. Plomp

Keyword(s):

Diffusion Model ◽

Magnetic Relaxation ◽

Liquid Crystalline ◽

Rotational Diffusion ◽

Nuclear Magnetic Relaxation ◽

Relaxation Study ◽

Nuclear Magnetic

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Tc-99m Labeled Complexes of Aldehydes and Glutamate as Cholescintigraphic Agents

Nuklearmedizin ◽

10.1055/s-0038-1624914 ◽

1975 ◽

Vol 14 (04) ◽

pp. 330-338

Author(s):

L. G. Colombetti ◽

J. S. Arnold ◽

W. E. Barnes

Keyword(s):

Nuclear Medicine ◽

Gall Bladder ◽

Rose Bengal ◽

Valence State ◽

Monosodium Glutamate ◽

Kinetic Studies ◽

Scintillation Camera ◽

Blood Clearance ◽

Lower Valence ◽

Wire Basket

SummaryTc-99m pyridoxylidene glutamate has proven to be an excellent biliary scanning agent, far superior in many respect to the commonly used 1-131 rose bengal. The preparation of the compound as previously reported by Baker et al is too time consuming and requires the use of an autoclave which is not available in most nuclear medicine departments. In our facility, we have been preparing similar compounds using several aldehydes and monosodium glutamate to make labeled complexes having the same pharmacological characteristics. The mixture of monosodium glutamate, aldehyde, and Tc-99m pertechnetate is made slightly alkaline, purged with helium, and placed in a sealed vial. The vial, which is protected by a wire basket, is then heated in a laboratory oven at 130° C for a period of 15 to 20 minutes. During this time, the technetium is reduced to a lower valence state and bound to the complex formed. Chromatographic data show that these compounds are chemically similar to that previously reported. The compounds prepared concentrate in the gall bladder of the rabbit in less than 10 minutes. Kinetic studies have been performed on dogs with a scintillation camera and small digital computer to measure rates of blood clearance, liver and gall bladder uptake, and excretion into the intestine. The aldehyde — glutamate complex promises to be a useful scanning agent for the diagnosis of biliary and hepatocellular diseases.

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