Structure and decomposition path of the HIF radical

1991 ◽  
Vol 95 (1) ◽  
pp. 433-440 ◽  
Author(s):  
Stanislaw A. Kucharski ◽  
Rodney J. Bartlett
Keyword(s):  
1981 ◽  
Vol 83 (1) ◽  
pp. 78-82 ◽  
Author(s):  
K. Yamashita ◽  
M. Kaminoyama ◽  
T. Yamabe ◽  
K. Fukui

1999 ◽  
Vol 59 (1) ◽  
pp. 16-19 ◽  
Author(s):  
Zhi-Rong Liu ◽  
Bing-Lin Gu ◽  
Hong Gui ◽  
Xiao-Wen Zhang

2011 ◽  
Vol 36 (19) ◽  
pp. 12279-12285 ◽  
Author(s):  
Jon Erling Fonneløp ◽  
Ole Martin Løvvik ◽  
Magnus H. Sørby ◽  
Hendrik W. Brinks ◽  
Bjørn C. Hauback
Keyword(s):  

2001 ◽  
Vol 40 (20) ◽  
pp. 5215-5222 ◽  
Author(s):  
R. Niewa ◽  
F. R. Wagner ◽  
W. Schnelle ◽  
O. Hochrein ◽  
R. Kniep

2002 ◽  
Vol 85 (2) ◽  
pp. 349-354
Author(s):  
Carola F Ferreyra ◽  
Cristina S Ortiz ◽  
María M de Bertorello

Abstract The main objective of this study was to develop and test the applicability of a sensitive, accurate, and precise liquid chromatographic (LC) method for evaluating the stability characteristics of a new bisisoxazolylnaphthoquinone, 2-(3,5-dimethyl-4-isoxazolylamino)-N-(3,5-dimethyl-4-isoxazolyl)-1,4-naphthoquinone-4-imine compound 1. The method was shown to be selective and stability-indicating. Isocratic elution with a mobile phase of methanol–water (75 + 25, v/v) on a reversed-phase column with UV detection at ambient temperature completely resolved compound 1 from its degradation products. The LC system was calibrated by plotting peak responses versus known concentrations of a reference standard by using an internal standardization procedure. Complete elution occurred after 12 min with a peak symmetry factor of 0.95 for the drug peak. The kinetic degradation of compound 1 was studied over a pH range of 0.88–14.00 to determine the kinetic parameters involved in its decomposition path in aqueous solution.


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