The Torpedo marmorate electrocyte: Developmental changes in the subcellular distribution of the 43K (ν1) protein suggest a role for the 43K protein in the stabilization of acetylcholine receptors

1991 ◽  
Author(s):  
Hoàng-Oanh Nghie^m ◽  
Joseph Hill ◽  
Jean-Pierre Changeux
Keyword(s):  
Subcellular Distribution ◽  
Acetylcholine Receptors ◽  
Developmental Changes

Comparison of subcellular distribution and functions between exogenous and endogenous M1 muscarinic acetylcholine receptors

Life Sciences ◽  
2013 ◽  
Vol 93 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Shigeru Morishima ◽  
Abu Syed Md Anisuzzaman ◽  
Junsuke Uwada ◽  
Hatsumi Yoshiki ◽  
Ikunobu Muramatsu
Keyword(s):  
Subcellular Distribution ◽  
Acetylcholine Receptors ◽  
Muscarinic Acetylcholine Receptors ◽  
Muscarinic Acetylcholine ◽  
M1 Muscarinic

Subcellular distribution of tight junction-associated proteins, occludin, ZO-1 and ZO-2, in rodent skin and its developmental changes

1998 ◽  
Vol 16 ◽  
pp. S71
Author(s):  
Kazumasa Morita ◽  
Masahiko Itoh ◽  
Mitinori Saitou ◽  
Yuhko Ando-Akatsuka ◽  
Mikio Furuse ◽  
...  
Keyword(s):  
Tight Junction ◽  
Subcellular Distribution ◽  
Developmental Changes ◽  
Associated Proteins

Developmental changes in the subcellular distribution of the 43K (v1) polypeptides in Torpedo marmorata electrocyte: support for a role in acetylcholine receptor stabilization

Development ◽  
1991 ◽  
Vol 113 (4) ◽  
pp. 1059-1067 ◽  
Author(s):  
H.O. Nghi:em ◽  
J. Hill ◽  
J.P. Changeux
Keyword(s):  
Acetylcholine Receptor ◽  
Subcellular Distribution ◽  
Protein Sequence ◽  
Developmental Changes ◽  
Antigenic Determinants ◽  
Mrna Transcript ◽  
Torpedo Marmorata ◽  
Maturation Phase ◽  
Massive Accumulation ◽  
Achr Clustering

Analysis of the relative amounts of the acetylcholine receptros (AChR) and of the 43K protein present in the membrane of developing electrocyte shows that massive accumulation of 43K protein is not required for induction of early AChR clustering. Furthermore, we demonstrate the existence o of cytosol- and membrane-associated 43K polypeptide pools in Torpedo electrocyte. Epitope analysis shows that both pools of 43K protein are related to the long mRNA transcript and share similar antigenic determinants distributed throughout the protein sequence. Their partition between the cytosol and membrane fractions abruptly increases in favor of the membrane during the postsynaptic maturation phase of development, supporting a role for 43K protein in the stabilization and maintenance of the postsynaptic domain.

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