Facile synthesis and magnetic property of iron oxide/MCM-41 mesoporous silica nanospheres for targeted drug delivery

2012 ◽  
Vol 111 (7) ◽  
pp. 07B514 ◽  
Author(s):  
Le-Le Yu ◽  
Hong Bi
Keyword(s):  
Drug Delivery ◽  
Magnetic Property ◽  
Iron Oxide ◽  
Mesoporous Silica ◽  
Targeted Drug Delivery ◽  
Silica Nanospheres ◽  
Facile Synthesis ◽  
Targeted Drug ◽  
Mesoporous Silica Nanospheres ◽  
Mcm 41

Preparation of hollow mesoporous silica nanospheres: controllable template synthesis and their application in drug delivery

2017 ◽  
Vol 41 (23) ◽  
pp. 14122-14129 ◽  
Author(s):  
Zia Ur Rahman ◽  
Ning Wei ◽  
Zhaoxia Li ◽  
Weixiang Sun ◽  
Daoai Wang
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Mesoporous Silica ◽  
Template Synthesis ◽  
Iron Oxide Nanoparticle ◽  
Silica Nanospheres ◽  
Oxide Nanoparticle ◽  
Hollow Mesoporous Silica ◽  
Mesoporous Silica Nanospheres

Hollow mesoporous silica nanospheres were prepared using iron oxide nanoparticle and polymer nanosphere templates and then applied for drug delivery.

scholarly journals ADAM9-Responsive Mesoporous Silica Nanoparticles for Targeted Drug Delivery in Pancreatic Cancer

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3321
Author(s):  
Etienne J. Slapak ◽  
Lily Kong ◽  
Mouad el Mandili ◽  
Rienk Nieuwland ◽  
Alexander Kros ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Conditioned Medium ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Pdac Cell ◽  
Targeted Drug

Pancreatic ductal adenocarcinoma (PDAC) has the worst survival rate of all cancers. This poor prognosis results from the lack of efficient systemic treatment regimens, demanding high-dose chemotherapy that causes severe side effects. To overcome dose-dependent toxicities, we explored the efficacy of targeted drug delivery using a protease-dependent drug-release system. To this end, we developed a PDAC-specific drug delivery system based on mesoporous silica nanoparticles (MSN) functionalized with an avidin–biotin gatekeeper system containing a protease linker that is specifically cleaved by tumor cells. Bioinformatic analysis identified ADAM9 as a PDAC-enriched protease, and PDAC cell-derived conditioned medium efficiently cleaved protease linkers containing ADAM9 substrates. Cleavage was PDAC specific as conditioned medium from leukocytes was unable to cleave the ADAM9 substrate. Protease linker-functionalized MSNs were efficiently capped with avidin, and cap removal was confirmed to occur in the presence of PDAC cell-derived ADAM9. Subsequent treatment of PDAC cells in vitro with paclitaxel-loaded MSNs indeed showed high cytotoxicity, whereas no cell death was observed in white blood cell-derived cell lines, confirming efficacy of the nanoparticle-mediated drug delivery system. Taken together, this research introduces a novel ADAM9-responsive, protease-dependent, drug delivery system for PDAC as a promising tool to reduce the cytotoxicity of systemic chemotherapy.

AIE Luminogen-Functionalized Hollow Mesoporous Silica Nanospheres for Drug Delivery and Cell Imaging

2016 ◽  
Vol 22 (11) ◽  
pp. 3681-3685 ◽  
Author(s):  
Zhiying Fan ◽  
Dongdong Li ◽  
Xue Yu ◽  
Yuping Zhang ◽  
Yong Cai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Cell Imaging ◽  
Silica Nanospheres ◽  
Hollow Mesoporous Silica ◽  
Mesoporous Silica Nanospheres

scholarly journals ROS-Responsive Chitosan Coated Magnetic Iron Oxide Nanoparticles as Potential Vehicles for Targeted Drug Delivery in Cancer Therapy

2020 ◽  
Vol Volume 15 ◽  
pp. 3333-3346 ◽  
Author(s):  
Srinivasan Ayyanaar ◽  
Chandrasekar Balachandran ◽  
Rangaswamy Chinnabba Bhaskar ◽  
Mookkandi Palsamy Kesavan ◽  
Shin Aoki ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Cancer Therapy ◽  
Iron Oxide Nanoparticles ◽  
Targeted Drug Delivery ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide ◽  
Targeted Drug

scholarly journals A Composite of Hyaluronic Acid-Modified Graphene Oxide and Iron Oxide Nanoparticles for Targeted Drug Delivery and Magnetothermal Therapy

ACS Omega ◽  
2019 ◽  
Vol 4 (5) ◽  
pp. 9284-9293 ◽  
Author(s):  
Nilkamal Pramanik ◽  
Santhalakshmi Ranganathan ◽  
Sunaina Rao ◽  
Kaushik Suneet ◽  
Shilpee Jain ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Hyaluronic Acid ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Targeted Drug Delivery ◽  
Oxide Nanoparticles ◽  
Modified Graphene Oxide ◽  
Targeted Drug ◽  
Modified Graphene

MRI Enhancement and Tumor Targeted Drug Delivery Using Zn2+-Doped Fe3O4 Core/Mesoporous Silica Shell Nanocomposites

2020 ◽  
Vol 3 (3) ◽  
pp. 1690-1697
Author(s):  
Weijun Fang ◽  
Wenjuan Zhu ◽  
Hu Chen ◽  
Hanyuan Zhang ◽  
Shi Hong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Targeted Drug Delivery ◽  
Silica Shell ◽  
Targeted Drug ◽  
Fe3o4 Core
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