scholarly journals Electrotaxis of lung cancer cells in ordered three-dimensional scaffolds

2012 ◽  
Vol 6 (1) ◽  
pp. 014102 ◽  
Author(s):  
Yung-Shin Sun ◽  
Shih-Wei Peng ◽  
Keng-Hui Lin ◽  
Ji-Yen Cheng
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Three Dimensional ◽  
Lung Cancer Cells

Bioengineering three-dimensional culture model of human lung cancer cells: an improved tool for screening EGFR targeted inhibitors

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24083-24090 ◽  
Author(s):  
Dan-Dan Wang ◽  
Wei Liu ◽  
Jing-Jie Chang ◽  
Xu Cheng ◽  
Xiu-Zhen Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Three Dimensional ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Culture Model ◽  
Human Lung Cancer Cells ◽  
Targeted Inhibitors ◽  
Three Dimensional Culture

Bioengineering a three-dimensional culture model of human lung cancer cells for screening EGFR targeted inhibitors.

scholarly journals Src-mediated morphology transition of lung cancer cells in three-dimensional organotypic culture

2013 ◽  
Vol 13 (1) ◽  
pp. 16 ◽  
Author(s):  
Hong T Nguyen ◽  
Yan Zhuang ◽  
Lichun Sun ◽  
Steven P Kantrow ◽  
Jay K Kolls ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Organotypic Culture ◽  
Three Dimensional ◽  
Lung Cancer Cells ◽  
Morphology Transition

scholarly journals Growth of lung cancer cells in three-dimensional microenvironments reveals key features of tumor malignancy

2012 ◽  
Vol 4 (4) ◽  
pp. 440-448 ◽  
Author(s):  
Magdalena A. Cichon ◽  
Vladimir G. Gainullin ◽  
Ying Zhang ◽  
Derek C. Radisky
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Three Dimensional ◽  
Lung Cancer Cells ◽  
Key Features

Inhibitory effects of Actinidia Chinensis planch root extracts (acRoots) on human lung cancer cells through retinoic acid receptor beta

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Lingyan Wang ◽  
Jiayun Hou ◽  
Minghuan Zheng ◽  
Lin Shi
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Retinoic Acid Receptor ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Inhibitory Effects ◽  
The Core ◽  
Human Lung Cancer Cells ◽  
Receptor Beta

Actinidia Chinensis Planch roots (acRoots) are used to treat many cancers, although the anti-tumor mechanism by which acRoots inhibit cancer cell growth remains unclear. The present study aims at investigating inhibitory effects of acRoots on human lung cancer cells and potential mechanisms. Our data demonstrate that the inhibitory effects of acRoots on lung cancer cells depend on genetic backgrounds and phenotypes of cells. We furthermore found the expression of metabolism-associated gene profiles varied between acRoots-hypersensitive (H460) or hyposensitive lung cancer cells (H1299) after screening lung cancer cells with different genetic backgrounds. We selected retinoic acid receptor beta (RARB) as the core target within metabolism-associated core gene networks and evaluated RARB changes and roles in cells treated with acRoots at different concentrations and timeframes. Hypersensitive cancer cells with the deletion of RARB expression did not response to the treatment with acRoots, while RARB deletion did not change effects of acRoots on hyposensitive cells. Thus, it seems that RARB as the core target within metabolism-associated networks plays important roles in the regulation of lung cancer cell sensitivity to acRoots.

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