Computational insight into the effect of monovalent cations on the electronic, optical, and lattice dynamic properties of XInSe2 (X = Cu, Ag, Li)

2011 ◽  
Vol 109 (11) ◽  
pp. 113535 ◽  
Author(s):  
Yanlu Li ◽  
Weiliu Fan ◽  
Honggang Sun ◽  
Xiufeng Cheng ◽  
Pan Li ◽  
...  
2006 ◽  
Vol 73 ◽  
pp. 109-119 ◽  
Author(s):  
Chris Stockdale ◽  
Michael Bruno ◽  
Helder Ferreira ◽  
Elisa Garcia-Wilson ◽  
Nicola Wiechens ◽  
...  

In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent advances in the understanding of chromatin structure and dynamics are highlighted. The ways in which different modes of nucleosome reconfiguration are likely to influence each other are discussed, and some of the factors likely to regulate the dynamic properties of nucleosomes are considered.


2018 ◽  
Vol 531 ◽  
pp. 16-20 ◽  
Author(s):  
Selgin Al ◽  
Nihat Arikan ◽  
Süleyman Demir ◽  
Ahmet Iyigör

2003 ◽  
Vol 17 ◽  
pp. 266-269
Author(s):  
V Lemos ◽  
E.B Barros ◽  
V.N Freire ◽  
J.R Gonçalves ◽  
J Mendes Filho

2020 ◽  
Vol 89 (1) ◽  
pp. 389-415 ◽  
Author(s):  
Anaïs M.E. Cassaignau ◽  
Lisa D. Cabrita ◽  
John Christodoulou

Folding of polypeptides begins during their synthesis on ribosomes. This process has evolved as a means for the cell to maintain proteostasis, by mitigating the risk of protein misfolding and aggregation. The capacity to now depict this cellular feat at increasingly higher resolution is providing insight into the mechanistic determinants that promote successful folding. Emerging from these studies is the intimate interplay between protein translation and folding, and within this the ribosome particle is the key player. Its unique structural properties provide a specialized scaffold against which nascent polypeptides can begin to form structure in a highly coordinated, co-translational manner. Here, we examine how, as a macromolecular machine, the ribosome modulates the intrinsic dynamic properties of emerging nascent polypeptide chains and guides them toward their biologically active structures.


2018 ◽  
Vol 52 (6) ◽  
pp. 2433-2456 ◽  
Author(s):  
Ayuna Barlukova ◽  
Diana White ◽  
Gérard Henry ◽  
Stéphane Honoré ◽  
Florence Hubert

Microtubules (MTs) are protein polymers that exhibit a unique type of behavior referred to as dynamic instability. That is, they undergo periods of growth (through the addition of GTP-tubulin) and shortening (through the subtraction of GDP-tubulin). Shortening events are very fast, where this transition is referred to as a catastrophe. There are many processes that regulate MT dynamic instability, however, recent experiments show that MT dynamics may be highly regulated by a MTs age, where young MTs are less likely to undergo shortening events than older ones. In this paper, we develop a novel modeling approach to describe how the age of a MT affects its dynamic properties. In particular, we extend on a previously developed model that describes MT dynamics, by proposing a new concept for GTP-tubulin hydrolysis (the process by which newly incorporated GTP-tubulin is hydrolyzed to lower energy GDP-tubulin). In particular, we assume that hydrolysis is mainly vectorial, age-dependent and delayed according to the GTP-tubulin incorporation into the MT. Through numerical simulation, we are able to show how MT age affects certain properties that define MT dynamics. For example, simulations illustrate how the aging process leads to an increase in the rate of GTP-tubulin hydrolysis for older MTs, as well as increases in catastrophe frequency. Also, since it has been found that MT dynamic instability is affected by chemotherapy microtubule-targeting agents (MTAs), we highlight the fact that our model can be used to investigate the action of MTAs on MT dynamics by varying certain model parameters.


2015 ◽  
Vol 592 ◽  
pp. 012119 ◽  
Author(s):  
M Mihalik ◽  
M Mihalik ◽  
M Fitta ◽  
M Vavra ◽  
M Zentková ◽  
...  

2006 ◽  
Vol 128 (4) ◽  
pp. 995-998
Author(s):  
Przemysław Herman

The precise control of a manipulator depends on its velocity as well as on its configuration and dynamic properties. This paper presents some observations that can serve as a useful tool for identifying nonlinear ear effects in a manipulator. The tool is based on equations of motion being expressed in terms of inertial quasi-velocities (IQVs). They are rates containing both kinematic and mechanical parameters of the system. The presented approach gives a further insight into the manipulator motion. An analytical example shows the proposed strategy.


2007 ◽  
Vol 21 (23n24) ◽  
pp. 4091-4103
Author(s):  
DONALD C. CHANG

To illustrate the power of the biophysical approach in solving important problems in life science, I present here one of our current research projects as example. We have developed special biophotonic techniques to study the dynamic properties of signaling proteins in a single living cell. This study allowed us to gain new insight into the signaling mechanism regulating programmed cell death.


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