Delay-enhanced spatiotemporal order in coupled neuronal systems

2010 ◽  
Vol 20 (4) ◽  
pp. 043140 ◽  
Author(s):  
Hao Wu ◽  
Zhonghuai Hou ◽  
Houwen Xin
Keyword(s):  
Neuronal Systems

scholarly journals RNA–Binding Protein HuD as a Versatile Factor in Neuronal and Non–Neuronal Systems

Biology ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 361
Author(s):  
Myeongwoo Jung ◽  
Eun-Kyung Lee
Keyword(s):  
Gene Expression ◽  
Neural Plasticity ◽  
Molecular Mechanisms ◽  
Neuronal Development ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Novel Treatments ◽  
Target Mrnas ◽  
Neuronal Systems

HuD (also known as ELAVL4) is an RNA–binding protein belonging to the human antigen (Hu) family that regulates stability, translation, splicing, and adenylation of target mRNAs. Unlike ubiquitously distributed HuR, HuD is only expressed in certain types of tissues, mainly in neuronal systems. Numerous studies have shown that HuD plays essential roles in neuronal development, differentiation, neurogenesis, dendritic maturation, neural plasticity, and synaptic transmission by regulating the metabolism of target mRNAs. However, growing evidence suggests that HuD also functions as a pivotal regulator of gene expression in non–neuronal systems and its malfunction is implicated in disease pathogenesis. Comprehensive knowledge of HuD expression, abundance, molecular targets, and regulatory mechanisms will broaden our understanding of its role as a versatile regulator of gene expression, thus enabling novel treatments for diseases with aberrant HuD expression. This review focuses on recent advances investigating the emerging role of HuD, its molecular mechanisms of target gene regulation, and its disease relevance in both neuronal and non–neuronal systems.

Effects of carbon monoxide exposure on serotonergic neuronal systems in rat brain

Life Sciences ◽  
1998 ◽  
Vol 62 (23) ◽  
pp. 2101-2108
Author(s):  
M. Muraoka ◽  
H. Hayakawa ◽  
A. Kagaya ◽  
T. Kojima ◽  
S. Yamawaki
Keyword(s):  
Carbon Monoxide ◽  
Rat Brain ◽  
Neuronal Systems

Effects of prenatal exposure to the CB-1 receptor agonist WIN 55212-2 or CO on the GABAergic neuronal systems of rat cerebellar cortex

Neuroscience ◽  
2007 ◽  
Vol 149 (3) ◽  
pp. 592-601 ◽  
Author(s):  
V. Benagiano ◽  
L. Lorusso ◽  
P. Flace ◽  
F. Girolamo ◽  
A. Rizzi ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Cerebellar Cortex ◽  
Receptor Agonist ◽  
Neuronal Systems

scholarly journals Cooperation of different neuronal systems during hand sign recognition

NeuroImage ◽  
2004 ◽  
Vol 23 (1) ◽  
pp. 25-34 ◽  
Author(s):  
Akinori Nakamura ◽  
Burkhard Maess ◽  
Thomas R. Knösche ◽  
Thomas C. Gunter ◽  
Patric Bach ◽  
...  
Keyword(s):  
Sign Recognition ◽  
Neuronal Systems

Effect of stochastic electromagnetic disturbances on autapse neuronal systems

2018 ◽  
Vol 27 (11) ◽  
pp. 118707 ◽  
Author(s):  
Liang-Hui Qu ◽  
Lin Du ◽  
Zi-Chen Deng ◽  
Zi-Lu Cao ◽  
Hai-Wei Hu
Keyword(s):  
Neuronal Systems ◽  
Electromagnetic Disturbances

scholarly journals Avian sarcoma leukosis virus receptor-envelope system for simultaneous dissection of multiple neural circuits in mammalian brain

2015 ◽  
Vol 112 (22) ◽  
pp. E2947-E2956 ◽  
Author(s):  
Makoto Matsuyama ◽  
Yohei Ohashi ◽  
Tadashi Tsubota ◽  
Masae Yaguchi ◽  
Shigeki Kato ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Gene Delivery ◽  
Cross Reactivity ◽  
Vector System ◽  
Target Cells ◽  
Specific Gene ◽  
Multiple Target ◽  
Neuronal Systems ◽  
Avian Sarcoma

Pathway-specific gene delivery is requisite for understanding complex neuronal systems in which neurons that project to different target regions are locally intermingled. However, conventional genetic tools cannot achieve simultaneous, independent gene delivery into multiple target cells with high efficiency and low cross-reactivity. In this study, we systematically screened all receptor–envelope pairs resulting from the combination of four avian sarcoma leukosis virus (ASLV) envelopes (EnvA, EnvB, EnvC, and EnvE) and five engineered avian-derived receptors (TVA950, TVBS3, TVC, TVBT, and DR-46TVB) in vitro. Four of the 20 pairs exhibited both high infection rates (TVA–EnvA, 99.6%; TVBS3–EnvB, 97.7%; TVC–EnvC, 98.2%; and DR-46TVB–EnvE, 98.8%) and low cross-reactivity (<2.5%). Next, we tested these four receptor–envelope pairs in vivo in a pathway-specific gene-transfer method. Neurons projecting into a limited somatosensory area were labeled with each receptor by retrograde gene transfer. Three of the four pairs exhibited selective transduction into thalamocortical neurons expressing the paired receptor (>98%), with no observed cross-reaction. Finally, by expressing three receptor types in a single animal, we achieved pathway-specific, differential fluorescent labeling of three thalamic neuronal populations, each projecting into different somatosensory areas. Thus, we identified three orthogonal pairs from the list of ASLV subgroups and established a new vector system that provides a simultaneous, independent, and highly specific genetic tool for transferring genes into multiple target cells in vivo. Our approach is broadly applicable to pathway-specific labeling and functional analysis of diverse neuronal systems.

scholarly journals Role of dopaminergic and serotonergic neuronal systems in the prefrontal cortex of rats in phencyclidine-induced behaviors.

1986 ◽  
Vol 9 (12) ◽  
pp. 987-996 ◽  
Author(s):  
KAZUMASA YAMAGUCHI ◽  
TOSHITAKA NABESHIMA ◽  
TSUTOMU KAMEYAMA
Keyword(s):  
Prefrontal Cortex ◽  
Neuronal Systems
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