scholarly journals Synthesis of Gold Nanorods for Biomedical Applications

2010 ◽  
Author(s):  
M. A. García ◽  
V. Bouzas ◽  
N. Carmona ◽  
Elisabetta Borsella
Keyword(s):  
Gold Nanorods ◽  
Biomedical Applications

scholarly journals Thermo-responsive polymer encapsulated gold nanorods for single continuous wave laser-induced photodynamic/photothermal tumour therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Beilei Gong ◽  
Yuanbing Shen ◽  
Huiyan Li ◽  
Xiaojun Li ◽  
Xia Huan ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Biomedical Applications ◽  
Continuous Wave ◽  
Continuous Wave Laser ◽  
Tumour Site ◽  
Polymer Shell ◽  
Potential System ◽  
Responsive Polymer ◽  
Good Biocompatibility ◽  
Spr Effect

AbstractOwing to strong and tunable surface plasmon resonance (SPR) effect and good biocompatibility, gold nanoparticles have been suggested to be a versatile platform for a broad range of biomedical applications. In this study, a new nanoplatform of thermo-responsive polymer encapsulated gold nanorods incorporating indocyanine green (ICG) was designed to couple the photothermal properties of gold nanorods (AuNRs) and the photodynamic properties of ICG to enhance the photodynamic/photothermal combination therapy (PDT/PTT). In addition to the significantly increased payload and enhancing photostability of ICG, the polymer shell in the nanoplatform also has thermo-responsive characteristics that can control the release of drugs at tumour sites upon the laser irradiation. On the basis of these improvements, the nanoplatform strongly increased drug aggregation at the tumour site and improved the photothermal/photodynamic therapeutic efficacy. These results suggest that this nanoplatform would be a great potential system for tumour imaging and antitumour therapy.

Stable Conjugates of Peptides with Gold Nanorods for Biomedical Applications with Reduced Effects on Cell Viability

2013 ◽  
Vol 5 (10) ◽  
pp. 4076-4085 ◽  
Author(s):  
Carolina Adura ◽  
Simon Guerrero ◽  
Edison Salas ◽  
Luis Medel ◽  
Ana Riveros ◽  
...  
Keyword(s):  
Cell Viability ◽  
Gold Nanorods ◽  
Biomedical Applications

scholarly journals Thermo-Responsive Polymer Encapsulated Gold Nanorods for Single Continuous Wave Laser-Induced Photodynamic/ Photothermal Tumour Therapy

2020 ◽  
Author(s):  
Beilei Gong ◽  
Yuanbing Shen ◽  
Huiyan Li ◽  
Xiaojun Li ◽  
Xia Huan ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Biomedical Applications ◽  
Continuous Wave ◽  
Continuous Wave Laser ◽  
Tumour Imaging ◽  
Tumour Site ◽  
Polymer Shell ◽  
Potential System ◽  
Good Biocompatibility ◽  
Spr Effect

Abstract Gold nanoparticles have been proven suggested to be a versatile platform for a broad range of biomedical applications owing to their strong and tunable surface plasmon resonance (SPR) effect and good biocompatibility. In this study, a new nanoplatform composed of thermo-responsivepolymer encapsulated gold nanorods incorporating ICG was designed to couple the photothermal properties of gold nanorods (AuNRs) and the photodynamic properties of ICG for enhanced photodynamic/photothermal combination therapy (PDT/PTT). For the nanoplatform, in addition to significantly increasing theICG payload with the additional benefit of enhancing ICG photostability, the polymer shell also has thermo-responsive characteristics, which can control the release of drugs at tumour sites afterlaser irradiation. On the basis of these improvements, the nanoplatform strongly increased drug aggregation at the tumour site and improvedthe photothermal/photodynamic therapeutic efficacy by inhibiting the growth of tumours in mice aftermild laser irradiation. These results suggest that thisnanoplatform is a great potential system for tumour imaging and antitumour therapy.

Multiple gold nanorods@hierarchically porous silica nanospheres for efficient multi-drug delivery and photothermal therapy

2017 ◽  
Vol 5 (8) ◽  
pp. 1642-1649 ◽  
Author(s):  
Nan Li ◽  
Dechao Niu ◽  
Xiaobo Jia ◽  
Jianping He ◽  
Yu Jiang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Porous Silica ◽  
Photothermal Effect ◽  
Silica Nanospheres ◽  
Hierarchically Porous ◽  
Silica Nanocomposites ◽  
Hierarchically Porous Structure

Gold-based silica nanocomposites with hierarchically porous structure, as well as excellent photothermal effect, have shown great potentials in biomedical applications.

Synthesis, Physico-Chemical Properties, and Biomedical Applications of Gold Nanorods—A Review

2016 ◽  
Vol 12 (6) ◽  
pp. 1136-1158 ◽  
Author(s):  
ValeriaS. Marangoni ◽  
Juliana Cancino-Bernardi ◽  
Valtencir Zucolotto
Keyword(s):  
Gold Nanorods ◽  
Biomedical Applications ◽  
Chemical Properties ◽  
Physico Chemical

A facile strategy to functionalize gold nanorods with polycation brushes for biomedical applications

2014 ◽  
Vol 10 (8) ◽  
pp. 3786-3794 ◽  
Author(s):  
Peng Yan ◽  
Nana Zhao ◽  
Hao Hu ◽  
Xinyi Lin ◽  
Fusheng Liu ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Biomedical Applications

scholarly journals Oligoarginine Peptide Conjugated to BSA Improves Cell Penetration of Gold Nanorods and Nanoprisms for Biomedical Applications

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1204
Author(s):  
Karen Bolaños ◽  
Macarena Sánchez-Navarro ◽  
Andreas Tapia-Arellano ◽  
Ernest Giralt ◽  
Marcelo J. Kogan ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cell Viability ◽  
Gold Nanorods ◽  
Biomedical Applications ◽  
Colloidal Stability ◽  
Cell Penetration ◽  
Cell Internalization ◽  
Gold Nanoprisms ◽  
A Cell ◽  
Endogenous Proteins

Gold nanoparticles (AuNPs) have been shown to be outstanding tools for drug delivery and biomedical applications, mainly owing to their colloidal stability, surface chemistry, and photothermal properties. The biocompatibility and stability of nanoparticles can be improved by capping the nanoparticles with endogenous proteins, such as albumin. Notably, protein coating of nanoparticles can interfere with and decrease their cell penetration. Therefore, in the present study, we functionalized albumin with the r8 peptide (All-D, octaarginine) and used it for coating NIR-plasmonic anisotropic gold nanoparticles. Gold nanoprisms (AuNPrs) and gold nanorods (AuNRs) were coated with bovine serum albumin (BSA) previously functionalized using a cell penetrating peptide (CPP) with the r8 sequence (BSA-r8). The effect of the coated and r8-functionalized AuNPs on HeLa cell viability was assessed by the MTS assay, showing a low effect on cell viability after BSA coating. Moreover, the internalization of the nanostructures into HeLa cells was assessed by confocal microscopy and transmission electron microscopy (TEM). As a result, both nanoconstructs showed an improved internalization level after being capped with BSA-r8, in contrast to the BSA-functionalized control, suggesting the predominant role of CPP functionalization in cell internalization. Thus, our results validate both novel nanoconstructs as potential candidates to be coated by endogenous proteins and functionalized with a CPP to optimize cell internalization. In a further approach, coating AuNPs with CPP-functionalized BSA can broaden the possibilities for biomedical applications by combining their optical properties, biocompatibility, and cell-penetration abilities.

scholarly journals Fabrication of Calcium Phosphate-Based Nanocomposites Incorporating DNA Origami, Gold Nanorods, and Anticancer Drugs for Biomedical Applications

2017 ◽  
Vol 6 (20) ◽  
pp. 1700664 ◽  
Author(s):  
Hongbo Zhang ◽  
Xiangmeng Qu ◽  
Hong Chen ◽  
Haixin Kong ◽  
Ruihua Ding ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Anticancer Drugs ◽  
Gold Nanorods ◽  
Biomedical Applications ◽  
Dna Origami

scholarly journals Biomedical Applications of Nanomaterials: Diagnosis and Therapy of Thrombotic Disorders

2017 ◽  
Vol 53 (01) ◽  
pp. 036-040
Author(s):  
D. Dash
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Near Infrared ◽  
Infrared Laser ◽  
Coronary Risk ◽  
Innovative Strategy ◽  
Diagnosis And Therapy ◽  
Metallic Nanomaterials

ABSTRACTWe have employed unique properties of carbon-based as well as metallic nanomaterials to develop diagnostic / therapeutic devices targeted against thrombotic disorders. We have designed a novel graphene-based biosensor that can detect individuals with high coronary risk. Further, we describe an innovative strategy to ablate pathological thrombus in situ employing near-infrared laser-irradiated gold nanorods (photothermal therapy).

scholarly journals Ready-to-use protein G-conjugated gold nanorods for biosensing and biomedical applications

2018 ◽  
Vol 16 (1) ◽  
Author(s):  
S. Centi ◽  
F. Ratto ◽  
F. Tatini ◽  
S. Lai ◽  
R. Pini
Keyword(s):  
Gold Nanorods ◽  
Biomedical Applications ◽  
Protein G
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