Phase separations of amorphous CoW films during oxidation and reactions with Si and Al

1989 ◽  
Vol 65 (5) ◽  
pp. 1957-1967 ◽  
Author(s):  
S. Q. Wang ◽  
J. W. Mayer
Keyword(s):  
Phase Separations

scholarly journals Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2118
Author(s):  
Yusuke Hosoya ◽  
Junko Ohkanda
Keyword(s):  
Drug Targets ◽  
Intrinsically Disordered Proteins ◽  
Dynamic Control ◽  
Disordered Proteins ◽  
Biological Processes ◽  
Phase Separations ◽  
Cellular Processes ◽  
Intrinsically Disordered ◽  
New Drug ◽  
Liquid Phase Separations

Intrinsically disordered proteins (IDPs) are critical players in the dynamic control of diverse cellular processes, and provide potential new drug targets because their dysregulation is closely related to many diseases. This review focuses on several medicinal studies that have identified low-molecular-weight inhibitors of IDPs. In addition, clinically relevant liquid–liquid phase separations—which critically involve both intermolecular interactions between IDPs and their posttranslational modification—are analyzed to understand the potential of IDPs as new drug targets.

scholarly journals DEAD-box helicases modulate dicing body formation in Arabidopsis

2021 ◽  
Vol 7 (18) ◽  
pp. eabc6266
Author(s):  
Qi Li ◽  
Ningkun Liu ◽  
Qing Liu ◽  
Xingguo Zheng ◽  
Lu Lu ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Turnip Mosaic Virus ◽  
Liquid Droplets ◽  
Phase Separations ◽  
Body Formation ◽  
Cellular Processes ◽  
Dead Box ◽  
Body Components ◽  
Liquid Phase Separations ◽  
Spatiotemporal Control

Eukaryotic cells contain numerous membraneless organelles that are made from liquid droplets of proteins and nucleic acids and that provide spatiotemporal control of various cellular processes. However, the molecular mechanisms underlying the formation and rapid stress-induced alterations of these organelles are relatively uncharacterized. Here, we investigated the roles of DEAD-box helicases in the formation and alteration of membraneless nuclear dicing bodies (D-bodies) in Arabidopsis thaliana. We uncovered that RNA helicase 6 (RH6), RH8, and RH12 are previously unidentified D-body components. These helicases interact with and promote the phase separation of SERRATE, a key component of D-bodies, and drive the formation of D-bodies through liquid-liquid phase separations (LLPSs). The accumulation of these helicases in the nuclei decreases upon Turnip mosaic virus infections, which couples with the decrease of D-bodies. Our results thus reveal the key roles of RH6, RH8, and RH12 in modulating D-body formation via LLPSs.

Evaluation of "Dexsil 300 GC" as Stationary Phase in Gas Chromatography of Triiodothyronine and Thyroxine in Human Serum

1973 ◽  
Vol 19 (1) ◽  
pp. 109-112 ◽  
Author(s):  
Mohammed Tajuddin ◽  
Stanley G Elfbaum
Keyword(s):  
Gas Chromatography ◽  
Stationary Phase ◽  
Human Serum ◽  
Methyl Esters ◽  
Phase Separations ◽  
Heat Stable

Abstract The N,O-dipivalyl methyl esters of triiodothyronine and thyroxine were prepared and gas chromatographed. "Dexsil 300 GC," a heat-stable polycarboranesiloxane, was used as the stationary phase. Separations were good and prompt. As little as 250 pg of triiodothyronine was detectable. Dexsil 300 GC was used satisfactorily in measuring serum triiodothyronine

scholarly journals Configurable Lipid Membrane Gradients Quantify Diffusion, Phase Separations and Binding Densities

2016 ◽  
Vol 110 (3) ◽  
pp. 17a
Author(s):  
Katherine N. Liu ◽  
Chen-Min S. Hung ◽  
Michael A. Swift ◽  
Kristen A. Muñoz ◽  
Jose L. Cortez ◽  
...  
Keyword(s):  
Lipid Membrane ◽  
Phase Separations ◽  
Diffusion Phase

Lateral phase separations in Escherichia coli membranes

1974 ◽  
Vol 345 (2) ◽  
pp. 220-230 ◽  
Author(s):  
Wolfgang Kleemann ◽  
Harden M. McConnell
Keyword(s):  
Escherichia Coli ◽  
Phase Separations

Critical dynamics of lateral and transversal phase separations in bilayer biomembranes and surfactants

2009 ◽  
Vol 29 (3) ◽  
pp. 319-327 ◽  
Author(s):  
M. Ouarch ◽  
M. Benhamou ◽  
M. Chahid ◽  
H. Kaidi
Keyword(s):  
Critical Dynamics ◽  
Phase Separations
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