scholarly journals Effects of side-chain packing on the formation of secondary structures in protein folding

2010 ◽  
Vol 132 (6) ◽  
pp. 065105 ◽  
Author(s):  
Satoshi Yasuda ◽  
Takashi Yoshidome ◽  
Hiraku Oshima ◽  
Ryota Kodama ◽  
Yuichi Harano ◽  
...  
Keyword(s):  
Protein Folding ◽  
Secondary Structures ◽  
Side Chain ◽  
Chain Packing ◽  
Side Chain Packing

Does the molten globule have a native-like tertiary fold?

1995 ◽  
Vol 348 (1323) ◽  
pp. 43-47 ◽  
Keyword(s):  
Protein Folding ◽  
Molten Globule ◽  
Side Chain ◽  
Structural Rearrangements ◽  
Chain Packing ◽  
Folding Intermediates ◽  
Final Structure ◽  
Helical Domain ◽  
Side Chain Packing

One of the mysteries in protein folding is how folding intermediates direct a protein to its unique final structure. To address this question, we have studied the molten globule formed by the α-helical domain of α-lactalbumin (α-LA) and demonstrated that it has a native-like tertiary fold, even in the absence of rigid, extensive side chain packing. These studies suggest that the role of molten globule intermediates in protein folding is to maintain an approximate native backbone topology while still allowing minor structural rearrangements to occur.

scholarly journals 1P-047 Roles of side-chain packing in the formation of secondary structures of a protein(Protein:Property, The 47th Annual Meeting of the Biophysical Society of Japan)

2009 ◽  
Vol 49 (supplement) ◽  
pp. S70
Author(s):  
Satoshi Yasuda ◽  
Ryota Kodama ◽  
Takashi Yoshidome ◽  
Yuichi Harano ◽  
Masahiro Kinoshita
Keyword(s):  
Annual Meeting ◽  
Secondary Structures ◽  
Side Chain ◽  
Chain Packing ◽  
Biophysical Society ◽  
Side Chain Packing
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