How to Determine Experimentally the Fano Factor in DROIDs

Author(s):  
Victor V. Samedov ◽  
Betty Young ◽  
Blas Cabrera ◽  
Aaron Miller
Keyword(s):  
1970 ◽  
Vol 17 (3) ◽  
pp. 187-195 ◽  
Author(s):  
H. R. Zulliger ◽  
D. W. Aitken
Keyword(s):  

2016 ◽  
Vol 213 (10) ◽  
pp. 2629-2633 ◽  
Author(s):  
Takehiro Shimaoka ◽  
Junichi H. Kaneko ◽  
Yuki Sato ◽  
Masakatsu Tsubota ◽  
Hiroaki Shimmyo ◽  
...  

1997 ◽  
Vol 82 (2) ◽  
pp. 871-877 ◽  
Author(s):  
A. Pansky ◽  
A. Breskin ◽  
R. Chechik
Keyword(s):  
Ion Pair ◽  
X Ray ◽  
The Mean ◽  

2004 ◽  
Vol 16 (11) ◽  
pp. 2261-2291 ◽  
Author(s):  
Garrett T. Kenyon ◽  
James Theiler ◽  
John S. George ◽  
Bryan J. Travis ◽  
David W. Marshak

Synchronous firing limits the amount of information that can be extracted by averaging the firing rates of similarly tuned neurons. Here, we show that the loss of such rate-coded information due to synchronous oscillations between retinal ganglion cells can be overcome by exploiting the information encoded by the correlations themselves. Two very different models, one based on axon-mediated inhibitory feedback and the other on oscillatory common input, were used to generate artificial spike trains whose synchronous oscillations were similar to those measured experimentally. Pooled spike trains were summed into a threshold detector whose output was classified using Bayesian discrimination. For a threshold detector with short summation times, realistic oscillatory input yielded superior discrimination of stimulus intensity compared to rate-matched Poisson controls. Even for summation times too long to resolve synchronous inputs, gamma band oscillations still contributed to improved discrimination by reducing the total spike count variability, or Fano factor. In separate experiments in which neurons were synchronized in a stimulus-dependent manner without attendant oscillations, the Fano factor increased markedly with stimulus intensity, implying that stimulus-dependent oscillations can offset the increased variability due to synchrony alone.


2013 ◽  
Vol 20 (6) ◽  
pp. 1071-1078 ◽  
Author(s):  
E. Piegari ◽  
R. Di Maio ◽  
A. Avella

Abstract. Reasonable prediction of landslide occurrences in a given area requires the choice of an appropriate probability distribution of recurrence time intervals. Although landslides are widespread and frequent in many parts of the world, complete databases of landslide occurrences over large periods are missing and often such natural disasters are treated as processes uncorrelated in time and, therefore, Poisson distributed. In this paper, we examine the recurrence time statistics of landslide events simulated by a cellular automaton model that reproduces well the actual frequency-size statistics of landslide catalogues. The complex time series are analysed by varying both the threshold above which the time between events is recorded and the values of the key model parameters. The synthetic recurrence time probability distribution is shown to be strongly dependent on the rate at which instability is approached, providing a smooth crossover from a power-law regime to a Weibull regime. Moreover, a Fano factor analysis shows a clear indication of different degrees of correlation in landslide time series. Such a finding supports, at least in part, a recent analysis performed for the first time of an historical landslide time series over a time window of fifty years.


2020 ◽  
Author(s):  
Pavol Bokes ◽  
Abhyudai Singh

AbstractClonal populations of microbial and cancer cells are often driven into a drug-tolerant persister state in response to drug therapy, and these persisters can subsequently adapt to the new drug environment via genetic and epigenetic mechanisms. Estimating the frequency with which drug-tolerance states arise, and its transition to drug-resistance, is critical for designing efficient treatment schedules. Here we study a stochastic model of cell proliferation where drug-tolerant persister cells transform into a drug-resistant state with a certain adaptation rate, and the resistant cells can then proliferate in the presence of the drug. Assuming a random number of persisters to begin with, we derive an exact analytical expression for the statistical moments and the distribution of the total cell count (i.e., colony size) over time. Interestingly, for Poisson initial conditions the noise in the colony size (as quantified by the Fano factor) becomes independent of the initial condition and only depends on the adaptation rate. Thus, experimentally quantifying the fluctuations in the colony sizes provides an estimate of the adaptation rate, which then can be used to infer the starting persister numbers from the mean colony size. Overall, our analysis introduces a modification of the classical Luria–Delbrück experiment, also called the “Fluctuation Test”, providing a valuable tool to quantify the emergence of drug resistance in cell populations.


2011 ◽  
Vol 38 (10) ◽  
pp. 1008010
Author(s):  
张合勇 Zhang Heyong ◽  
郭劲 Guo Jin ◽  
赵帅 Zhao Shuai ◽  
王挺峰 Wang Tingfeng ◽  
刘立生 Liu Lisheng

Author(s):  
Wilfred K. Fullagar ◽  
Mahsa Paziresh ◽  
Shane J. Latham ◽  
Glenn R. Myers ◽  
Andrew M. Kingston

In statistics, the index of dispersion (or variance-to-mean ratio) is unity (σ2/〈x〉 = 1) for a Poisson-distributed process with variance σ2for a variablexthat manifests as unit increments. Wherexis a measure of some phenomenon, the index takes on a value proportional to the quanta that constitute the phenomenon. That outcome might thus be anticipated to apply for an enormously wide variety of applied measurements of quantum phenomena. However, in a photon-energy proportional radiation detector, a set ofMwitnessed Poisson-distributed measurements {W1,W2,…WM} scaled so that the ideal expectation value of the quantum is unity, is generally observed to give σ2/〈W〉 < 1 because of detector losses as broadly indicated by Fano [Phys. Rev.(1947),72, 26]. In other cases where there is spectral dispersion, σ2/〈W〉 > 1. Here these situations are examined analytically, in Monte Carlo simulations, and experimentally. The efforts reveal a powerful metric of quanta broadly associated with such measurements, where the extension has been made to polychromatic and lossy situations. In doing so, the index of dispersion's variously established yet curiously overlooked role as a metric of underlying quanta is indicated. The work's X-ray aspects have very diverse utility and have begun to find applications in radiography and tomography, where the ability to extract spectral information from conventional intensity detectors enables a superior level of material and source characterization.


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