MRI-Controlled Rapidly Scanned Focused Ultrasound Hyperthermia for Temperature Sensitive Localized Drug Delivery

2009 ◽  
Author(s):  
Robert Staruch ◽  
Jeff Wachsmuth ◽  
Rajiv Chopra ◽  
Kullervo Hynynen ◽  
Emad S. Ebbini
Keyword(s):  
Drug Delivery ◽  
Focused Ultrasound ◽  
Temperature Sensitive ◽  
Ultrasound Hyperthermia ◽  
Localized Drug Delivery

Synergistic agents for tumor-specific therapy mediated by focused ultrasound treatment

2021 ◽  
Author(s):  
Wonseok Choi ◽  
Chulhong Kim
Keyword(s):  
Drug Delivery ◽  
Focused Ultrasound ◽  
Ultrasound Treatment ◽  
Tumor Treatment ◽  
Specific Therapy ◽  
Image Guided Therapy ◽  
Image Guided ◽  
Localized Drug Delivery ◽  
Guided Therapy

In this minireview, synergistic agents for focused ultrasound tumor treatment are reviewed in four therapy mechanisms: sonodynamic plus chemotherapy, microbubble-aided therapy, localized drug delivery, and photoacoustic image-guided therapy.

scholarly journals High Intensity Focused Ultrasound Technology, its Scope and Applications in Therapy and Drug Delivery

2014 ◽  
Vol 17 (1) ◽  
pp. 136 ◽  
Author(s):  
Christopher Peter Phenix ◽  
Melissa Togtema ◽  
Samuel Pichardo ◽  
Ingeborg Zehbe ◽  
Laura Curiel
Keyword(s):  
Drug Delivery ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Biological Effects ◽  
Pharmaceutical Research ◽  
Drug Carriers ◽  
High Intensity Focused Ultrasound ◽  
Temperature Sensitive ◽  
Therapeutic Applications ◽  
Living Tissues

Ultrasonography is a safe, inexpensive and wide-spread diagnostic tool capable of producing real-time non-invasive images without significant biological effects. However, the propagation of higher energy, intensity and frequency ultrasound waves through living tissues can induce thermal, mechanical and chemical effects useful for a variety of therapeutic applications. With the recent development of clinically approved High Intensity Focused Ultrasound (HIFU) systems, therapeutic ultrasound is now a medical reality.  Indeed, HIFU has been used for the thermal ablation of pathological lesions; localized, minimally invasive ultrasound-mediated drug delivery through the transient formation of pores on cell membranes; the temporary disruption of skin and the blood brain barrier; the ultrasound induced break-down of blood clots; and the targeted release of drugs using ultrasound and temperature sensitive drug carriers. This review seeks to engage the pharmaceutical research community by providing an overview on the biological effects of ultrasound as well as highlighting important therapeutic applications, current deficiencies and future directions.This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

Enhanced drug delivery in rabbit VX2 tumours using thermosensitive liposomes and MRI-controlled focused ultrasound hyperthermia

2012 ◽  
Vol 28 (8) ◽  
pp. 776-787 ◽  
Author(s):  
Robert M. Staruch ◽  
Milan Ganguly ◽  
Ian F. Tannock ◽  
Kullervo Hynynen ◽  
Rajiv Chopra
Keyword(s):  
Drug Delivery ◽  
Focused Ultrasound ◽  
Thermosensitive Liposomes ◽  
Ultrasound Hyperthermia

Low-intensity focused ultrasound mediated localized drug delivery for liver tumors in rabbits

Drug Delivery ◽  
2014 ◽  
Vol 23 (7) ◽  
pp. 2280-2289 ◽  
Author(s):  
Yuping Gong ◽  
Zhigang Wang ◽  
Guifang Dong ◽  
Yang Sun ◽  
Xi Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Focused Ultrasound ◽  
Liver Tumors ◽  
Low Intensity ◽  
Localized Drug Delivery
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