A broadband continuous-wave multichannel near-infrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets

2009 ◽  
Vol 80 (5) ◽  
pp. 054302 ◽  
Author(s):  
Mamadou Diop ◽  
Jonathan T. Elliott ◽  
Kenneth M. Tichauer ◽  
Ting-Yim Lee ◽  
Keith St. Lawrence
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Oxygen Consumption ◽  
Regional Cerebral Blood Flow ◽  
Near Infrared ◽  
Continuous Wave ◽  
Regional Cerebral Blood ◽  
Newborn Piglets

Regional cerebral blood flow response during and after acute asphyxia in newborn piglets

1989 ◽  
Vol 66 (6) ◽  
pp. 2827-2832 ◽  
Author(s):  
J. M. Goplerud ◽  
L. C. Wagerle ◽  
M. Delivoria-Papadopoulos
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Stem ◽  
Regional Cerebral Blood Flow ◽  
Muscle Blood Flow ◽  
Organ Blood Flow ◽  
Brain Blood Flow ◽  
Regional Cerebral Blood ◽  
Newborn Piglets ◽  
Total Brain

The hemodynamic response during and after acute asphyxia was studied in 14 newborn piglets. An apnea-like asphyxial insult was produced in paralyzed mechanically ventilated piglets by discontinuing ventilation until the piglets became bradycardic (heart rate less than 80 beats/min). Seven piglets had organ blood flow measured by microspheres at control, during asphyxia (PO2 = 16 +/- 11 Torr, pH = 7.31 +/- 0.07, PCO2 = 47 +/- 9 Torr), and during recovery from asphyxia. During acute asphyxia, rapid organ blood flow redistribution occurred, producing decreased renal and skeletal muscle blood flow, while coronary blood flow increased. Although total brain blood flow changed little during asphyxia, regional cerebral blood flow (rCBF) analysis revealed significant nonhomogeneous blood flow distribution within the brain during asphyxia, with decreases to the cerebral gray and white matter and the choroid plexus, whereas brain stem structures had increased flow. During recovery with reventilation, total brain blood flow increased 24% above control, with a more uniform distribution and increased flow to all brain regions. The time course of rCBF changes during acute asphyxia was then determined in seven additional piglets with CBF measurements made sequentially at 30–60 s, 60–120 s, and 120–180 s of asphyxia. The vasoconstriction seen in cortical structures, concurrent with the reduction in skeletal and kidney blood flow, known to be sympathetically mediated, suggest a selective reflex effect in this brain region. The more gradual and progressive vasodilation in brain stem regions during asphyxia is consistent with chemical control. These findings demonstrate significant regional heterogeneity in CBF regulation in newborn piglets.

Sympathetic nerve modulation of regional cerebral blood flow during asphyxia in newborn piglets

1991 ◽  
Vol 260 (5) ◽  
pp. H1575-H1580 ◽  
Author(s):  
J. M. Goplerud ◽  
L. C. Wagerle ◽  
M. Delivoria-Papadopoulos
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Sympathetic Nerve ◽  
Regional Cerebral Blood Flow ◽  
Brain Cortex ◽  
Regional Cerebral Blood ◽  
Newborn Piglets ◽  
Vasoconstrictor Response ◽  
Sympathetic Modulation ◽  
Cervical Sympathetic

Regional cerebral blood flow (rCBF) during asphyxia suggests a reflex vasoconstrictor mechanism active principally in brain cortex. Present studies in newborn piglets investigate sympathetic modulation of the cerebrovasculature both during and after acute asphyxia. Unilateral superior cervical sympathetic ganglionectomy (SCSG) was performed in 13 newborn piglets, after which asphyxia was produced by discontinuing ventilation. In 8 animals, blood flow was measured during control and sequentially 1, 2, and 3 min after ventilation was stopped. In 5 piglets with unilateral SCSG, cortical flow decreased in the innervated hemisphere, -34 +/- 14% after 2 min, and -25 +/- 9% at 3 min of asphyxia compared with control (104 +/- 22 ml.min-1.100 g-1; mean +/- SE). In contrast, the sympathetically denervated hemisphere showed -13 +/- 17% at 2 min and +7 +/- 23% at 3 min, representing 45 +/- 6% and 30 +/- 9% left-right (L-R) flow differences, respectively. Bilateral SCSG (3 piglets) similarly attenuated the cortical CBF vasoconstrictor response to asphyxia, +6 +/- 21% at 2 min and -8 +/- 5% at 3 min. Significant innervated-denervated rCBF differences were present during asphyxia in cerebral gray (55% +/- 24), cerebral white (41% +/- 16), caudate (25% +/- 7), hippocampus (36% +/- 12), and choroid plexus (145% +/- 42), indicating sympathetic nerve modulation. Brain stem structures showed increasing rCBF throughout asphyxia and no L-R differences.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Regional cerebral blood flow and oxygen consumption of the canine brain during hemorrhagic hypotension.

Stroke ◽  
1984 ◽  
Vol 15 (2) ◽  
pp. 343-350 ◽  
Author(s):  
R Y Chen ◽  
F C Fan ◽  
G B Schuessler ◽  
S Simchon ◽  
S Kim ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Oxygen Consumption ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Hemorrhagic Hypotension ◽  
Canine Brain
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