Type 2 Diabetes and Uric Acid Nephrolithiasis

2008 ◽  
Author(s):  
Naim M. Maalouf ◽  
James C. Williams ◽  
Andrew P. Evan ◽  
James E. Lingeman ◽  
James A. McAteer
Keyword(s):  
Type 2 Diabetes ◽  
Uric Acid ◽  
Uric Acid Nephrolithiasis

scholarly journals Renal ammonium excretion after an acute acid load: blunted response in uric acid stone formers but not in patients with type 2 diabetes

2013 ◽  
Vol 305 (10) ◽  
pp. F1498-F1503 ◽  
Author(s):  
I. Alexandru Bobulescu ◽  
Naim M. Maalouf ◽  
Giovanna Capolongo ◽  
Beverley Adams-Huet ◽  
Tara R. Rosenthal ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Uric Acid ◽  
Ammonium Excretion ◽  
Acid Excretion ◽  
Uric Acid Stone ◽  
Stone Formers ◽  
Uric Acid Nephrolithiasis ◽  
Acid Load ◽  
Acid Challenge

Idiopathic uric acid nephrolithiasis is characterized by elevated urinary net acid excretion and insufficient buffering by ammonium, resulting in excessively acidic urine and titration of the relatively soluble urate anion to insoluble uric acid. Patients with type 2 diabetes have similar changes in urinary pH, net acid excretion, and ammonium in 24-h urine collections at baseline, even after controlling for dietary factors, and are at increased risk for uric acid nephrolithiasis. However, not all patients with type 2 diabetes develop kidney stones, suggesting that uric acid stone formers may have additional urinary defects, perhaps not apparent at baseline. We performed a metabolic study of 14 patients with idiopathic uric acid nephrolithiasis, 13 patients with type 2 diabetes, and 8 healthy control subjects of similar body mass index. After equilibration on a fixed diet for 5 days, subjects were given a single oral acid load (50 meq ammonium chloride), and urine was collected hourly for 4 h. Uric acid stone formers had a lower ammonium excretory response to acute acid loading compared with diabetic and nondiabetic nonstone formers, suggesting that an ammonium excretory defect unique to uric acid stone formers was unmasked by the acid challenge. The Zucker diabetic fatty rat also did not show impaired urinary ammonium excretion in response to acute acid challenge. A blunted renal ammonium excretory response to dietary acid loads may contribute to the pathogenesis of idiopathic uric acid nephrolithiasis.

scholarly journals Urine Composition in Type 2 Diabetes: Predisposition to Uric Acid Nephrolithiasis

2006 ◽  
Vol 17 (5) ◽  
pp. 1422-1428 ◽  
Author(s):  
Mary Ann Cameron ◽  
Naim M. Maalouf ◽  
Beverley Adams-Huet ◽  
Orson W. Moe ◽  
Khashayar Sakhaee
Keyword(s):  
Type 2 Diabetes ◽  
Uric Acid ◽  
Uric Acid Nephrolithiasis ◽  
Urine Composition

Rheumatoid Factor in Type 2 Male Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

2018 ◽  
Vol 4 (2) ◽  
pp. 58-62
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Kazi Nazneen Sultana ◽  
Nizamul Hoque Bhuiyan ◽  
Md Jamil Hasan Karami ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Rheumatoid Factor ◽  
Serum Uric Acid ◽  
Control Group ◽  
Healthy Male ◽  
Male Patients

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62

Relation of elevated serum uric acid levels to first-degree heart block and other cardiac conduction defects in hospitalized patients with type 2 diabetes

2017 ◽  
Vol 31 (12) ◽  
pp. 1691-1697 ◽  
Author(s):  
Alessandro Mantovani ◽  
Riccardo Rigolon ◽  
Isabella Pichiri ◽  
Giovanni Morani ◽  
Stefano Bonapace ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Heart Block ◽  
Elevated Serum ◽  
Hospitalized Patients ◽  
Cardiac Conduction ◽  
Degree Heart Block

scholarly journals Association Between Serum Uric Acid and Development of Type 2 Diabetes

Diabetes Care ◽  
2009 ◽  
Vol 32 (9) ◽  
pp. 1737-1742 ◽  
Author(s):  
S. Kodama ◽  
K. Saito ◽  
Y. Yachi ◽  
M. Asumi ◽  
A. Sugawara ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Uric Acid ◽  
Serum Uric Acid

scholarly journals Relationship Between Serum Uric Acid and Incident Hypertension in Patients with Type 2 Diabetes

2017 ◽  
Vol 14 (4) ◽  
pp. 354-363
Author(s):  
Mohsen Janghorbani ◽  
Heshmatollah Ghanbari ◽  
Ashraf Aminorroaya ◽  
Masoud Amini
Keyword(s):  
Type 2 Diabetes ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Incident Hypertension
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