Direct current H[sup −] source for boron neutron capture therapy tandem accelerator

2008 ◽  
Vol 79 (2) ◽  
pp. 02A521 ◽  
Author(s):  
Yu. Belchenko ◽  
A. Sanin ◽  
I. Gusev ◽  
A. Khilchenko ◽  
A. Kvashnin ◽  
...  
Keyword(s):  
Direct Current ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Tandem Accelerator ◽  
Boron Neutron Capture

scholarly journals Исследование влияния пространственного заряда на транспортировку 2 MeV пучка протонов в ускорительном источнике эпитепловых нейтронов

2021 ◽  
Vol 91 (1) ◽  
pp. 105
Author(s):  
Т.А. Быков ◽  
Д.А. Касатов ◽  
Я.А. Колесников ◽  
А.М. Кошкарев ◽  
А.Н. Макаров ◽  
...  
Keyword(s):  
Proton Beam ◽  
Neutron Source ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Infrared Camera ◽  
Target Surface ◽  
Beam Current ◽  
Neutron Capture Therapy ◽  
Tandem Accelerator ◽  
Boron Neutron Capture

A neutron source comprised of a vacuum insulated tandem accelerator and a solid lithium target is in operation for development of boron neutron capture therapy and other applications. The size of the proton beam on the target surface depending on the proton beam current was measured using an infrared camera and thermocouples inserted inside the target. The absence of a noticeable influence of the space charge on the transportation of the proton beam from the accelerator to the target at a distance of 5 m has been established, which simplifies the operation of the neutron source.

Experiments to increase the parameters of the vacuum insulation tandem accelerator for boron neutron capture therapy

2016 ◽  
Vol 13 (7) ◽  
pp. 954-956
Author(s):  
D. A. Kasatov ◽  
J. A. Kolesnikov ◽  
A. M. Koshkarev ◽  
A. S. Kuznetsov ◽  
A. N. Makarov ◽  
...  
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Tandem Accelerator ◽  
Vacuum Insulation ◽  
Boron Neutron Capture

scholarly journals HGG-05. REGRESSION OF RECURRENT GLIOBLASTOMA AFTER BORON NEUTRON CAPTURE THERAPY AND CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY IN A CHILD

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii345-iii345
Author(s):  
Hsin-Hung Chen ◽  
Yi-Wei Chen
Keyword(s):  
T Cells ◽  
T Cell ◽  
Chimeric Antigen Receptor ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Antigen Receptor ◽  
Neutron Capture Therapy ◽  
T Cell Therapy ◽  
Boron Neutron Capture ◽  
Car T

Abstract A 6 y/o girl with recurrent multifocal glioblastoma received 3 times of boron neutron capture therapy (BNCT) and chimeric antigen receptor (CAR)–engineered T cells targeting the tumor-associated antigen HER2. Multiple infusions of CAR T cells were administered over 30 days through intraventricular delivery routes. It was not associated with any toxic effects of grade 3 or higher. After BNCT and CAR T-cell treatment, regression of all existing intracranial lesions were observed, along with corresponding increases in levels of cytokines and immune cells in the cerebrospinal fluid, but new lesions recurred soon after the treatment. This clinical response continued for 14 months after the initiation of first recurrence.

Nucleophilic radiosynthesis of boron neutron capture therapy-oriented PET probe [18F]FBPA using aryldiboron precursors

2021 ◽  
Author(s):  
Jing He ◽  
Heng Yan ◽  
Yanrong Du ◽  
Yan Ji ◽  
Fei Cai ◽  
...  
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

A reliable copper-mediated nucleophilic radiosynthesis of the BNCT-oriented PET probe [18F]FBPA was developed using novel aryldiboron precursors.

scholarly journals Optimized beam shaping assembly for a 2.1-MeV proton-accelerator-based neutron source for boron neutron capture therapy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pablo Torres-Sánchez ◽  
Ignacio Porras ◽  
Nataliya Ramos-Chernenko ◽  
Fernando Arias de Saavedra ◽  
Javier Praena
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Beam Shaping ◽  
Proton Accelerator ◽  
Neutron Capture Therapy ◽  
Beam Shape ◽  
New Era ◽  
Boron Neutron Capture ◽  
Optimal Beam ◽  
Beam Shaping Assembly

AbstractBoron Neutron Capture Therapy (BNCT) is facing a new era where different projects based on accelerators instead of reactors are under development. The new facilities can be placed at hospitals and will increase the number of clinical trials. The therapeutic effect of BNCT can be improved if a optimized epithermal neutron spectrum is obtained, for which the beam shape assembly is a key ingredient. In this paper we propose an optimal beam shaping assembly suited for an affordable low energy accelerator. The beam obtained with the device proposed accomplishes all the IAEA recommendations for proton energies between 2.0 and 2.1 MeV. In addition, there is an overall improvement of the figures of merit with respect to BNCT facilities and previous proposals of new accelerator-based facilities.

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