AbstractA recent paper by Karin, Swisa, Glaser, Dor, and Alon introduced the mathematical notion of dynamical compensation (DC) in biological circuits, arguing that DC helps explain important features of glucose homeostasis as well as other key physiological regulatory mechanisms. The present paper establishes a connection between DC and two well-known notions in systems biology: system equivalence and parameter (un)identifiability. This recasting leads to effective tests for verifying DC in mathematical models.
An Introduction to Systems Biology: Design Principles of Biological Circuits; Systems Biology: Properties of Reconstructed Networks An Introduction to Systems Biology: Design Principles of Biological Circuits ,
Uri Alon , Chapman & Hall/CRC/Taylor &
Francis, Boca Raton, FL,
2007. $49.95 paper (301 pp.). ISBN
978-1-58488-642-6 Systems Biology: Properties
of Reconstructed Networks ,
Bernhard Ø. Palsson , Cambridge U.
Press, New York, 2006. $75.00
(322 pp.). ISBN 978-0-521-85903-5