Characterization and Ultrasound-Pulse Mediated Destruction of Ultrasound Contrast Microbubbles

2006 ◽  
Author(s):  
Kausik Sarkar
Keyword(s):  
Ultrasound Contrast ◽  
Ultrasound Pulse ◽  
Contrast Microbubbles

Real-Time Excitation-Enhanced Ultrasound Contrast Imaging

2005 ◽  
Vol 27 (2) ◽  
pp. 65-74 ◽  
Author(s):  
Flemming Forsberg ◽  
William T. Shi ◽  
Michael K. Knauer ◽  
Anne L. Hall ◽  
Chris Vecchio ◽  
...  
Keyword(s):  
Real Time ◽  
Imaging Modality ◽  
Surrounding Tissue ◽  
Contrast Imaging ◽  
Maximum Enhancement ◽  
Ultrasound Contrast ◽  
Ultrasound Contrast Imaging ◽  
Contrast Microbubbles

A new nonlinear contrast specific imaging modality, excitation-enhanced imaging (EEI) has been implemented on commercially-available scanners for real-time imaging. This novel technique employs two acoustic fields: a low-frequency, high-intensity ultrasound field (the excitation field) to actively condition contrast microbubbles, and a second lower-intensity regular imaging field applied shortly afterwards to detect enhanced contrast scattering. A Logiq 9 scanner (GE Healthcare, Milwaukee, WI) with a 3.5C curved linear array and an AN2300 digital ultrasound engine (Analogic Corporation, Peabody, MA) with a P4-2 phased array transducer (Philips Medical Systems, Bothell, WA) were modified to perform EEI on a vector-by-vector basis in fundamental and pulse inversion harmonic grayscale modes. Ultrasound contrast microbubbles within an 8 mm vessel embedded in a tissue-mimicking flow phantom (ATS Laboratories, Bridgeport, CT) were imaged in vitro. While video intensities of scattered signals from the surrounding tissue were unchanged, video intensities of echoes from contrast bubbles within the vessel were markedly enhanced. The maximum enhancement achieved was 10.4 dB in harmonic mode (mean enhancement: 6.3 dB; p=0.0007). In conclusion, EEI may improve the sensitivity of ultrasound contrast imaging, but further work is required to assess the in vivo potential of this new technique.

scholarly journals Ultrasound contrast microbubbles in imaging and therapy: physical principles and engineering

2009 ◽  
Vol 54 (6) ◽  
pp. R27-R57 ◽  
Author(s):  
Shengping Qin ◽  
Charles F Caskey ◽  
Katherine W Ferrara
Keyword(s):  
Ultrasound Contrast ◽  
Physical Principles ◽  
Contrast Microbubbles
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