Multiphoton Imaging of Ultrasound Bioeffects in the Murine Brain

2006 ◽  
Author(s):  
Scott Raymond
Keyword(s):  
Multiphoton Imaging ◽  
Ultrasound Bioeffects ◽  
Murine Brain

scholarly journals Author Correction: High-pulse-energy multiphoton imaging of neurons and oligodendrocytes in deep murine brain with a fiber laser

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michael J. Redlich ◽  
Brad Prall ◽  
Edesly Canto-Said ◽  
Yevgeniy Busarov ◽  
Lilit Shirinyan-Tuka ◽  
...  
Keyword(s):  
Fiber Laser ◽  
Pulse Energy ◽  
High Pulse Energy ◽  
Multiphoton Imaging ◽  
High Pulse ◽  
Murine Brain

Preclinical Molecular Imaging of the Translocator Protein (TSPO) in a Metastases Model Based on Breast Cancer Xenografts Propagated in the Murine Brain

2012 ◽  
Vol 12 (4) ◽  
pp. 458-466
Author(s):  
Shelby K. Wyatt ◽  
H. Charles Manning ◽  
Mingfeng Bai ◽  
Moneeb Ehtesham ◽  
Khubaib Y. Mapara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Imaging ◽  
Translocator Protein ◽  
Model Based ◽  
Murine Brain ◽  
Breast Cancer Xenografts

scholarly journals Tumor-infiltrating macrophages influence the glycosphingolipid composition of murine brain tumors

1998 ◽  
Vol 39 (11) ◽  
pp. 2218-2227 ◽  
Author(s):  
Jeffrey A. Ecsedy ◽  
Herbert C. Yohe ◽  
Alan J. Bergeron ◽  
Thomas N. Seyfried
Keyword(s):  
Brain Tumors ◽  
Murine Brain

scholarly journals Multiphoton imaging and Raman spectroscopy of the bovine vertebral endplate

The Analyst ◽  
2021 ◽  
Author(s):  
Fay Crawford-Manning ◽  
Martha Z. Vardaki ◽  
Ellen Green ◽  
Judith R. Meakin ◽  
Claudio Vergari ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Vertebral Endplate ◽  
Micro Structure ◽  
Multiphoton Imaging

Multiphoton imaging and Raman spectroscopy reveal chemistry and micro-structure of the bovine vertebral endplate.

scholarly journals Multiphoton Imaging of Ca2+ Instability in Acute Myocardial Slices from a RyR2R2474S Murine Model of Catecholaminergic Polymorphic Ventricular Tachycardia

2021 ◽  
Vol 10 (13) ◽  
pp. 2821
Author(s):  
Giulia Borile ◽  
Tania Zaglia ◽  
Stephan E. Lehnart ◽  
Marco Mongillo
Keyword(s):  
Ventricular Tachycardia ◽  
Single Cells ◽  
Tissue Level ◽  
Catecholaminergic Polymorphic Ventricular Tachycardia ◽  
Polymorphic Ventricular Tachycardia ◽  
Adrenergic Stimulation ◽  
Release Channel ◽  
Multiphoton Imaging ◽  
Delayed Afterdepolarizations ◽  
Multiple Cells

Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is a familial stress-induced arrhythmia syndrome, mostly caused by mutations in Ryanodine receptor 2 (RyR2), the sarcoplasmic reticulum (SR) Ca2+ release channel in cardiomyocytes. Pathogenetic mutations lead to gain of function in the channel, causing arrhythmias by promoting diastolic spontaneous Ca2+ release (SCR) from the SR and delayed afterdepolarizations. While the study of Ca2+ dynamics in single cells from murine CPVT models has increased our understanding of the disease pathogenesis, questions remain on the mechanisms triggering the lethal arrhythmias at tissue level. Here, we combined subcellular analysis of Ca2+ signals in isolated cardiomyocytes and in acute thick ventricular slices of RyR2R2474S knock-in mice, electrically paced at different rates (1–5 Hz), to identify arrhythmogenic Ca2+ dynamics, from the sub- to the multicellular perspective. In both models, RyR2R2474S cardiomyocytes had increased propensity to develop SCR upon adrenergic stimulation, which manifested, in the slices, with Ca2+ alternans and synchronous Ca2+ release events in neighboring cardiomyocytes. Analysis of Ca2+ dynamics in multiple cells in the tissue suggests that SCRs beget SCRs in contiguous cells, overcoming the protective electrotonic myocardial coupling, and potentially generating arrhythmia triggering foci. We suggest that intercellular interactions may underscore arrhythmic propensity in CPVT hearts with ‘leaky’ RyR2.

Multiphoton imaging with sub-30 fs Yb fiber laser

2012 ◽  
Author(s):  
Ilyas Saytashev ◽  
Bai Nie ◽  
Andy Chong ◽  
Hui Liu ◽  
Sergey Arkhipov ◽  
...  
Keyword(s):  
Fiber Laser ◽  
Multiphoton Imaging
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