scholarly journals Feasibility Study for High Energy SEM-Based Reference Measurement System for Litho Metrology

2005 ◽  
Author(s):  
Michael Bishop
Keyword(s):  
Feasibility Study ◽  
Measurement System ◽  
High Energy ◽  
Reference Measurement ◽  
Reference Measurement System

scholarly journals Towards an SI-Traceable Reference Measurement System for Seven Serum Apolipoproteins Using Bottom-Up Quantitative Proteomics: Conceptual Approach Enabled by Cross-Disciplinary/Cross-Sector Collaboration

2020 ◽  
Author(s):  
Christa M Cobbaert ◽  
Harald Althaus ◽  
Ilijana Begcevic Brkovic ◽  
Uta Ceglarek ◽  
Stefan Coassin ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Cardiovascular Disease ◽  
Measurement System ◽  
Protein Quantification ◽  
Test Results ◽  
Conceptual Approach ◽  
Reference Measurement ◽  
Lipid Panel ◽  
Mass Spectrometry Technology ◽  
Reference Measurement System

Abstract Current dyslipidemia management in patients with atherosclerotic cardiovascular disease (ASCVD) is based on traditional serum lipids. Yet, there is some indication from basic research that serum apolipoproteins A-I, (a), B, C-I, C-II, C-III, and E may give better pathophysiological insight into the root causes of dyslipidemia. To facilitate the future adoption of clinical serum apolipoprotein (apo) profiling for precision medicine, strategies for accurate testing should be developed in advance. Recent discoveries in basic science and translational medicine set the stage for the IFCC Working Group on Apolipoproteins by Mass Spectrometry. Main drivers were the convergence of unmet clinical needs in cardiovascular disease (CVD) patients with enabling technology and metrology. First, the residual cardiovascular risk after accounting for established risk factors demonstrates that the current lipid panel is too limited to capture the full complexity of lipid metabolism in patients. Second, there is a need for accurate test results in highly polymorphic and atherogenic apolipoproteins such as apo(a). Third, sufficient robustness of mass spectrometry technology allows reproducible protein quantification at the molecular level. Fourth, several calibration hierarchies in the revised ISO 17511:2020 guideline facilitate metrological traceability of test results, the highest achievable standard being traceability to SI. This article outlines the conceptual approach aimed at achieving a novel, multiplexed Reference Measurement System (RMS) for seven apolipoproteins based on isotope dilution mass spectrometry and peptide-based calibration. This RMS should enable standardization of existing and emerging apolipoprotein assays to SI, within allowable limits of measurement uncertainty, through a sustainable network of Reference Laboratories.

scholarly journals PENETAPAN SISTEM ACUAN DAYA AC UNTUK LABORATORIUM STANDAR NASIONAL BERDASARKAN STANDARD WATT CONVERTER

2016 ◽  
Vol 17 (1) ◽  
pp. 11
Author(s):  
Agah Faisal
Keyword(s):  
Measurement System ◽  
Reference System ◽  
Digital Voltmeter ◽  
National Standard ◽  
National Metrology Institute ◽  
Standard Laboratory ◽  
Reference Measurement ◽  
Power Meter ◽  
Ac Power ◽  
Reference Measurement System

<p>Abstrak</p><p><br />Puslit KIM-LIPI telah mengembangkan suatu sistem pengukuran acuan daya AC untuk laboratorium standar nasional dengan ketelitian pengukuran yang lebih baik dari 75 ppm pada faktor cakupan 2 dan tingkat kepercayaan 95%. Sistem tersebut berbasis Standard Watt Converter (SWC), beban semu, dan digital DC voltmeter yang telah diketahui koreksinya melalui proses kalibrasi kepada standar yang dimiliki Lembaga Metrologi Nasional Australia (NMIA) dan Lembaga Metrologi Nasional Indonesia (Puslit KIM-LIPI). Metode perbandingan terhadap sistem acuan tersebut telah diterapkan pada suatu Unit Under Calibration (UUC) yang berupa power meter berketelitian tinggi. Hal ini dilakukan untuk menampilkan unjuk kerja sistem acuan daya AC dalam proses pengukuran koreksi pembacaan dari power meter. Hasil evaluasi pada titik-titik pengukuran 120 V, 5 A, dan 53 Hz menunjukkan bahwa koreksi pembacaan terbesar adalah 133 ppm. Nilai tersebut berkesesuian dengan kelas akurasi power meter ZERA RMM3001 yaitu 0,02% atau sebesar 200 ppm. Dari hasil unjuk kerja sistem pengukuran ini maka penetapan acuan daya AC untuk laboratorium standar nasional seperti Puslit KIM-LIPI mencukupi.<br />Kata kunci: sistem pengukuran acuan, daya AC, standard watt converter, koreksi pembacaan, power meter.</p><p><br />Abstract</p><p><br />Puslit KIM-LIPI has developed an AC power reference measurement system for a national standard laboratory with a measurement precision better than 75 ppm at coverage factor 2 and confidence level 95 %. The system was based on the instruments of a standard watt converter, a phantom load, and a standard digital voltmeter, which the corrections of those readings are known by calibration processes to both National Metrology Institute of Australia (NMIA) and Puslit KIM-LIPI. The comparison method of the AC power reference system has been applied to the high precision power meter as a unit under calibration (UUC). This was done to show the measurement performance of AC power reference system in the process to find the reading correction of the power meter under calibration. The measurement evaluation at 120 V, 5 A, and 53 Hz showed that the worst reading correction was 133 ppm. That value was on the agreement with the class accuracy of ZERA RMM3001 power meter which is 0,02 % or 200 ppm. The performance of the measurement system indicated that the establishment of the ac power reference for a national standard laboratory such as Puslit KIM-LIPI was adequate.<br />Keywords: reference measurement system, AC power, standard watt converter, reading correction, power meter.</p>

Irregular analytical errors in diagnostic testing – a novel concept

2018 ◽  
Vol 56 (3) ◽  
pp. 386-396 ◽  
Author(s):  
Michael Vogeser ◽  
Christoph Seger
Keyword(s):  
Quality Control ◽  
Measurement Uncertainty ◽  
Measurement System ◽  
Clinical Chemistry ◽  
Individual Sample ◽  
Reference Measurement ◽  
Analytical Error ◽  
The Individual ◽  
Analytical Errors ◽  
Reference Measurement System

AbstractBackground:In laboratory medicine, routine periodic analyses for internal and external quality control measurements interpreted by statistical methods are mandatory for batch clearance. Data analysis of these process-oriented measurements allows for insight into random analytical variation and systematic calibration bias over time. However, in such a setting, any individual sample is not under individual quality control. The quality control measurements act only at the batch level. Quantitative or qualitative data derived for many effects and interferences associated with anindividualdiagnostic sample can compromise any analyte. It is obvious that a process for a quality-control-sample-based approach of quality assurance is not sensitive to such errors.Content:To address the potential causes and nature of such analytical interference in individual samples more systematically, we suggest the introduction of a new term called theirregular(individual)analytical error. Practically, this term can be applied in any analytical assay that is traceable to a reference measurement system. For an individual sample an irregular analytical error is defined as an inaccuracy (which is the deviation from a reference measurement procedure result) of a test result that is so high it cannot be explained by measurement uncertainty of the utilized routine assay operating within the accepted limitations of the associated process quality control measurements.Summary:The deviation can be defined as the linear combination of the process measurement uncertainty and the method bias for the reference measurement system. Such errors should be coinedirregular analytical errorsof the individual sample. The measurement result is compromised either by an irregular effect associated with the individual composition (matrix) of the sample or an individual single sample associated processing error in the analytical process.Outlook:Currently, the availability of reference measurement procedures is still highly limited, but LC-isotope-dilution mass spectrometry methods are increasingly used for pre-market validation of routine diagnostic assays (these tests also involve substantial sets of clinical validation samples). Based on this definition/terminology, we list recognized causes of irregular analytical error as arisk catalogfor clinical chemistry in this article. These issues include reproducible individual analytical errors (e.g. caused by anti-reagent antibodies) and non-reproducible, sporadic errors (e.g. errors due to incorrect pipetting volume due to air bubbles in a sample), which can both lead to inaccurate results and risks for patients.

Requirement of a reference measurement system for the tissue factor-induced coagulation time and the international normalized ratio

2019 ◽  
Vol 57 (7) ◽  
pp. e169-e172
Author(s):  
Antonius M.H.P. van den Besselaar ◽  
Claudia J.J. van Rijn ◽  
Anthony R. Hubbard ◽  
Steve Kitchen ◽  
Armando Tripodi ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Measurement System ◽  
International Normalized Ratio ◽  
Coagulation Time ◽  
Reference Measurement ◽  
Reference Measurement System

Implementation of Reference Measurement System using CD-AFM

2003 ◽  
Author(s):  
Ronald G. Dixson ◽  
Angela Guerry ◽  
Marylyn H. Bennett ◽  
Theodore V. Vorburger ◽  
Benjamin D. Bunday
Keyword(s):  
Measurement System ◽  
Reference Measurement ◽  
Reference Measurement System

A new thoron atmosphere reference measurement system

2016 ◽  
Vol 109 ◽  
pp. 205-209 ◽  
Author(s):  
B. Sabot ◽  
S. Pierre ◽  
N. Michielsen ◽  
S. Bondiguel ◽  
P. Cassette
Keyword(s):  
Measurement System ◽  
Reference Measurement ◽  
Reference Measurement System
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