scholarly journals Highly sensitive optical response of optical fiber long period gratings to nanometer-thick ionic self-assembled multilayers

2005 ◽  
Vol 86 (22) ◽  
pp. 223104 ◽  
Author(s):  
Zhiyong Wang ◽  
J. R. Heflin ◽  
Rogers H. Stolen ◽  
Siddharth Ramachandran
Sensors ◽  
2020 ◽  
Vol 20 (13) ◽  
pp. 3772 ◽  
Author(s):  
Tinko Eftimov ◽  
Monika Janik ◽  
Marcin Koba ◽  
Mateusz Śmietana ◽  
Predrag Mikulic ◽  
...  

Selected optical fiber sensors offer extraordinary sensitivity to changes in external refractive (RI), which make them promising for label-free biosensing. In this work the most sensitive ones, namely long-period gratings working at (DTP-LPG) and micro-cavity in-line Mach-Zehnder interferometers (µIMZI) are discussed for application in bacteria sensing. We describe their working principles and RI sensitivity when operating in water environments, which is as high as 20,000 nm/RIU (Refractive index unit) for DTP-LPGs and 27,000 nm/RIU for µIMZIs. Special attention is paid to the methods to enhance the sensitivity by etching and nano-coatings. While the DTP-LPGs offer a greater interaction length and sensitivity to changes taking place at their surface, the µIMZIs are best suited for investigations of sub-nanoliter and picoliter volumes. The capabilities of both the platforms for bacteria sensing are presented and compared for strains of Escherichia coli, lipopolysaccharide E. coli, outer membrane proteins of E. coli, and Staphylococcus aureus. While DTP-LPGs have been more explored for bacteria detection in 102–106 Colony Forming Unit (CFU)/mL for S. aureus and 103–109 CFU/mL for E. coli, the µIMZIs reached 102–108 CFU/mL for E. coli and have a potential for becoming picoliter bacteria sensors.


2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Anthony Lim ◽  
Wen Bin Ji ◽  
Swee Chuan Tjin

A new structure of Long-Period Gratings (LPGs) sensor is introduced as a sensitive ambient RI sensor. This structure consists of creating periodic corrugations on the cladding of the LPG. The experimental results show that this LPG structure has good performances in terms of linearity and sensitivity and serves as a highly sensitive and cost-effective sensor. It also has the advantage of portability as the corrugation can also serve as the reservoir for the specimen collection to be tested.


Sensors ◽  
2020 ◽  
Vol 20 (3) ◽  
pp. 813 ◽  
Author(s):  
Marta Janczuk-Richter ◽  
Beata Gromadzka ◽  
Łukasz Richter ◽  
Mirosława Panasiuk ◽  
Karolina Zimmer ◽  
...  

Since the norovirus is the main cause of acute gastroenteritis all over the world, its fast detection is crucial in medical diagnostics. In this work, a rapid, sensitive, and selective optical fiber biosensor for the detection of norovirus virus-like particles (VLPs) is reported. The sensor is based on highly sensitive long-period fiber gratings (LPFGs) coated with antibodies against the main coat protein of the norovirus. Several modification methods were verified to obtain reliable immobilization of protein receptors on the LPFG surface. We were able to detect 1 ng/mL norovirus VLPs in a 40-min assay in a label-free manner. Thanks to the application of an optical fiber as the sensor, there is a possibility to increase the user’s safety by separating the measurement point from the signal processing setup. Moreover, our sensor is small and light, and the proposed assay is straightforward. The designed LPFG-based biosensor could be applied in both fast norovirus detection and in vaccine testing.


2019 ◽  
Vol 102 ◽  
pp. 103000 ◽  
Author(s):  
Jihong Liu ◽  
Minhui Cheng ◽  
Xudong Kong ◽  
Dongdong Han ◽  
Jun Dong ◽  
...  

2017 ◽  
Author(s):  
J. S. Hallett ◽  
M. Partridge ◽  
S. W. James ◽  
D. Tiwari ◽  
T. Farewell ◽  
...  

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