Barring ITER Site Consensus, Europe Will Forge Ahead

Physics Today ◽  
2005 ◽  
Vol 58 (1) ◽  
pp. 30-30
Author(s):  
Toni Feder
Keyword(s):  
Site Consensus

Role of the 3′ splice site consensus sequence in mammalian pre-mRNA splicing

Nature ◽  
1985 ◽  
Vol 317 (6039) ◽  
pp. 732-734 ◽  
Author(s):  
Barbara Ruskin ◽  
Michael R. Green
Keyword(s):  
Splice Site ◽  
Consensus Sequence ◽  
Mrna Splicing ◽  
Site Consensus

scholarly journals Tec1p-Independent Activation of a Hypha-Associated Candida albicans Virulence Gene during Infection

2004 ◽  
Vol 72 (4) ◽  
pp. 2386-2389 ◽  
Author(s):  
Peter Staib ◽  
Ayfer Binder ◽  
Marianne Kretschmar ◽  
Thomas Nichterlein ◽  
Klaus Schröppel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Candida Albicans ◽  
Animal Models ◽  
Environmental Conditions ◽  
Deletion Mutant ◽  
Virulence Gene ◽  
Consensus Sequences ◽  
Site Consensus

ABSTRACT The Tec1p transcription factor is involved in the expression of hypha-specific genes in Candida albicans. Although the induction of the hypha-associated SAP5 gene by serum in vitro depends on Tec1p, deletion of all Tec1p binding site consensus sequences from the SAP5 promoter did not affect its activation. In two different animal models of candidiasis, the SAP5 promoter was induced even in a Δtec1 deletion mutant, demonstrating that the requirement for Tec1p in gene expression in C. albicans depends on the environmental conditions within the host.

scholarly journals Multistress Regulation in Escherichia coli: Expression of osmB Involves Two Independent Promoters Responding either to σS or to the RcsCDB His-Asp Phosphorelay

2005 ◽  
Vol 187 (9) ◽  
pp. 3282-3286 ◽  
Author(s):  
Alice Boulanger ◽  
Anne Francez-Charlot ◽  
Annie Conter ◽  
Marie-Pierre Castanié-Cornet ◽  
Kaymeuang Cam ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Signal Transduction ◽  
Transcription Factors ◽  
Response Regulator ◽  
Osmotic Shock ◽  
Dependent Manner ◽  
Signal Transduction System ◽  
Upstream Promoter ◽  
Site Consensus ◽  
Escherichia Coli Expression

ABSTRACT Transcription of the Escherichia coli osmB gene is induced by several stress conditions. osmB is expressed from two promoters, osmBp1 and osmBp2. The downstream promoter, osmBp2, is induced after osmotic shock or upon entry into stationary phase in a σS-dependent manner. The upstream promoter, osmBp1, is independent of σS and is activated by RcsB, the response regulator of the His-Asp phosphorelay signal transduction system RcsCDB. RcsB is responsible for the induction of osmBp1 following treatment with chlorpromazine. Activation of osmBp1 by RcsB requires a sequence upstream of its −35 element similar to the RcsB binding site consensus, suggesting a direct regulatory role. osmB appears as another example of a multistress-responsive gene whose transcription involves both a σS-dependent promoter and a second one independent of σS but controlled by stress-specific transcription factors.

scholarly journals Transposition of Tn125encoding the NDM-1 carbapenemase inAcinetobacter baumannii

2016 ◽  
pp. AAC.01755-16 ◽  
Author(s):  
Séverine Bontron ◽  
Patrice Nordmann ◽  
Laurent Poirel
Keyword(s):  
Acinetobacter Baumannii ◽  
Direct Evidence ◽  
Opportunistic Pathogen ◽  
Target Site ◽  
Gram Negative Bacteria ◽  
Transposition Frequency ◽  
Gram Negative ◽  
Temperature Changes ◽  
Site Consensus ◽  
Almost All

TheblaNDM-1gene encodes a carbapenemase that confers resistance to almost all β-lactams, including latest resort carbapenems. It is increasingly reported worldwide in nosocomial and community-acquired Gram-negative bacteria.Acinetobacter baumanniiis an important opportunistic pathogen considered as an intermediate reservoir for theblaNDM-1gene. In this species, theblaNDM-1gene is located within the Tn125composite transposon. The mechanism driving the mobility of Tn125has not yet been elucidated. Here we experimentally demonstrated transposition of Tn125inA. baumannii. Systematic 3-bp duplication of the target site, being signature of transposition, was evidenced. The target site consensus for Tn125transposition was found to be GC-enriched at the duplicated 3 bp and AT-rich in the vicinity. Transposition frequency was not influenced by temperature changes or by exposure to sub-inhibitory concentrations of various antibiotics. This work is the first direct evidence of the functionality of a composite transposon inA. baumannii. It provides a mechanistic clue for the dissemination of theblaNDM-1gene inAcinetobacterspp. and subsequently among Enterobacteriaceae.

scholarly journals A 3′ splice site consensus sequence mutation in the intron 3 of the α-galactosidase a gene in a patient with Fabry disease

1991 ◽  
Vol 36 (3) ◽  
pp. 245-250 ◽  
Author(s):  
Tohru Yokoi ◽  
Kazuko Shinoda ◽  
Ichiro Ohno ◽  
Kimitaka Kato ◽  
Toshio Miyawaki ◽  
...  
Keyword(s):  
Fabry Disease ◽  
Splice Site ◽  
Consensus Sequence ◽  
Site Consensus
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