scholarly journals Discontinuous Change of Binding Type in the Series of Monohydrides. II. Place of Discontinuity

1964 ◽  
Vol 41 (12) ◽  
pp. 4005-4006 ◽  
Author(s):  
Kasimir Fajans
Keyword(s):  
Discontinuous Change ◽  
Binding Type

Intergenerational hybrid products in periods of discontinuous change

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Wilian Gatti Junior ◽  
Alceu Salles Camargo Junior ◽  
Paul Varella
Keyword(s):  
New Technologies ◽  
New Technology ◽  
Annual Reports ◽  
Discontinuous Change ◽  
Historical Case ◽  
Content Type ◽  
Industrial Sectors ◽  
Hybrid Products ◽  
Organizational Inertia

PurposeThis study examines the role of hybrid products employed in companies' innovation strategy within three American industrial sectors: tires, typewriters and photography cameras.Design/methodology/approachThe authors selected historical cases that enabled us to present the role of hybrid products in periods of discontinuous change. Different sources are employed in this study: papers, books, cases, working papers, videos, manuals and product catalogues, companies' annual reports, company websites, advertising, collectors' websites and museums, in addition to press and other media reports.FindingsThe authors’ historical case analysis points to two forms of hybrid products. (1) Exploitation-hybrid, which incorporates significant elements from the existing dominant design and aims at extending the revenue-generating opportunities of the existing products. (2) Exploration-hybrid, which works as an offensive strategy, as the firm uses the exploration-hybrid to promote a gradual and controlled adoption of new technology by reducing risks and the cost of change for the customer.Research limitations/implicationsThe authors’ proposed definitions strengthen the idea that hybrids are not only a reflection of organizational inertia (exploitation-hybrid). Hybrids can also mean a more proactive stance in the strategy of developing and adopting new technology (exploration-hybrid).Originality/valueThis study acknowledged hybrid products as a learning instrument that materialized the organizational ambidexterity, favoring at the same time exploitation, generally attributed to organizational inertia, and the exploration of new segments of customers or the use of new technologies.

Exploring the Interaction of Ethidium Bromide and HOECHST 33258 with DNA by Means of Electrochemical Approach

2017 ◽  
Vol 12 (03) ◽  
pp. 151-161
Author(s):  
Levon A. Tavadyan ◽  
Seyran H. Minasyan ◽  
Gaspar H. Kocharyan ◽  
Ara P. Antonyan ◽  
Viktoria G. Sahakyan ◽  
...  
Keyword(s):  
Ethidium Bromide ◽  
Square Wave Voltammetry ◽  
Differential Pulse ◽  
Binding Modes ◽  
Hoechst 33258 ◽  
Wave Voltammetry ◽  
Calf Thymus ◽  
Electrochemical Approach ◽  
Pulse Voltammetry ◽  
Binding Type

The binding of both ethidium bromide (EtBr) and Hoechst 33258 (H33258) to calf thymus DNA differing by the mechanism at different ionic strengths of NaCl water solutions (2, 20 and 150[Formula: see text]mM) has been quantitatively studied by square wave voltammetry (SWV). It was revealed that EtBr binds to DNA by more than one mode: at the solution ionic strengths 2 and 150[Formula: see text]mM, two modes were revealed, at 20[Formula: see text]mM — three modes. Values of EtBr binding constant ([Formula: see text]) to DNA and the number of nucleotides per one binding site ([Formula: see text]) for respective binding modes were determined. For H33258 under the same conditions, two binding modes were found and for both these modes values of [Formula: see text] and [Formula: see text] were determined. Dependence of the binding types and parameters on the solution ionic strength by SWV method was revealed, which differs by the binding type of EtBr and H33258. The obtained data are in good accordance with the ones determined by spectroscopic (absorption and fluorescence) and differential pulse voltammetry (DPV) methods. The obtained data indicate the sensibility and high precision of SWV method which may be applied to studies on interaction of different ligands with DNA, which reveal some peculiarities of their binding to DNA that are hidden and are not found by other methods.

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