Nuclear Magnetic Resonance in Paramagnetic Solutions. A Correlation between Contact Shifts and Nuclear Spin Coupling Constants

1971 ◽  
Vol 54 (7) ◽  
pp. 3238-3239 ◽  
Author(s):  
Isao Morishima ◽  
Teijiro Yonezawa
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Nuclear Spin ◽  
Coupling Constants ◽  
Spin Coupling ◽  
Spin Coupling Constants ◽  
Nuclear Magnetic

Carbon-13 nuclear magnetic resonance studies of (Z)-5-fluoro-2-methyl-1-{[p-(methylsulfinyl)phenyl] methylene}-1H-indene-3-acetic acid (sulindac) and some related compounds

1978 ◽  
Vol 56 (16) ◽  
pp. 2129-2133 ◽  
Author(s):  
Alan Wilmot Douglas
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Acetic Acid ◽  
Magnetic Resonance ◽  
Nuclear Spin ◽  
Substituent Effects ◽  
Coupling Constants ◽  
Spin Coupling ◽  
Nuclear Magnetic Resonance Spectra ◽  
Spin Coupling Constants ◽  
Nuclear Magnetic

Carbon-13 nuclear magnetic resonance spectra have been obtained and fully assignee for a number of 2-methyl-1-{[p-(methylthio) or -(methylsulfinyl}phenyl]methylene}-1H-indene-3- acetic acid derivatives, including the potent anti-inflammatory compound sulindac, 1Z. Paired E and Z isomers were studied along with the sulindac sodium salt and ethyl ester in the Z series. Variations in steric crowding in E vs. Z isomers produce chemical shift effects which alternate with the number of intervening bonds. Fluorine substituent effects and 19F nuclear spin coupling to 13C nuclei, second-order features in off-resonance proton-decoupled spectra, and values of long-range 13CH nuclear spin coupling constants have been employed in making a complete set of assignments.

PREFERRED RESIDENCE CONFORMATIONS OF DIASTEREOISOMERIC α–β AMINO ALCOHOLS: AN N.M.R. STUDY OF THE EPHEDRINES

1961 ◽  
Vol 39 (12) ◽  
pp. 2536-2542 ◽  
Author(s):  
J. B. Hyne
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Hydrogen Bonding ◽  
Magnetic Resonance ◽  
Chemical Shifts ◽  
Amino Alcohols ◽  
Coupling Constants ◽  
Spin Coupling ◽  
Spin Coupling Constants ◽  
Nuclear Magnetic

Nuclear magnetic resonance spectral results including chemical shifts, anisotropy effects, spin coupling constants, and hydrogen bonding phenomena are presented for the diastereoisomeric pair of α–β amino alcohols (−)-ephedrine and (+)-Ψ-ephedrine. The results are shown to be in keeping with the existence of a preferred residence conformation for each of the diastereoisomers.

Nuclear magnetic resonance of some fluoro-substituted phenyl and benzyl mercurials

1968 ◽  
Vol 21 (10) ◽  
pp. 2411 ◽  
Author(s):  
W Kitching ◽  
W Adcock ◽  
BF Hegarty
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Nuclear Magnetic Resonance Data ◽  
Coupling Constants ◽  
Spin Coupling ◽  
Electronic Effects ◽  
Magnetic Resonance Data ◽  
Resonance Data ◽  
Spin Coupling Constants ◽  
Nuclear Magnetic

l9F and lH nuclear magnetic resonance data are reported for the para and meta fluoro-phenyl and -benzyl mercurials of types R2Hg and RHgX where X is a halide. The 19F data for the fluorophenyl mercurials provide no evidence for direct aryl-mercury conjugation, and mercuri substituents exert very feeble electronic effects. The shielding for the fluorobenzyl mercurials suggests a quite pronounced o-p electron donating effect for the metallomethyl group (NCH2-). Some 199Hg-lH spin coupling constants are derived from the proton spectra of the benzyl mercurials.

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