Binary homogeneous nucleation in water–succinic acid and water–glutaric acid systems

2004 ◽  
Vol 120 (1) ◽  
pp. 282-291 ◽  
Author(s):  
Anca I. Gaman ◽  
Markku Kulmala ◽  
Hanna Vehkamäki ◽  
Ismo Napari ◽  
Mihaela Mircea ◽  
...  
Keyword(s):  
Succinic Acid ◽  
Homogeneous Nucleation ◽  
Glutaric Acid

STUDIES ON REACTIONS RELATING TO CARBOHYDRATES AND POLYSACCHARIDES: XXXII. THE CONSTITUTION OF SEDOSAN (ANHYDRO-SEDOHEPTOSE)

1930 ◽  
Vol 3 (4) ◽  
pp. 306-317 ◽  
Author(s):  
Harold Hibbert ◽  
C. G. Anderson
Keyword(s):  
Nitric Acid ◽  
Succinic Acid ◽  
Glutaric Acid ◽  
Primary Alcohol ◽  
Alcohol Group

Methylation of sedosan (anhydro-sedoheptose) gives a tetramethyl sedosan, which on oxidation by nitric acid, yields an optically inactive trimethoxy glutaric acid. By esterifying the latter, and treating the ester with anhydrous methylamine, an optically inactive methylamide, presumably trimethoxy riboglutaro-dimethylamide is obtained. No trace of the methylamide of inactive dimethoxy succinic acid could be found. It is thus concluded that sedose possesses a 2:6 oxygen ring and that sedosan is an anhydro-sedopyranose.This is confirmed by the isolation of monotrityl sedosan, which shows that sedosan has only one primary alcohol group. Sedosan is therefore 2:7-anhydro-sedopyranose.The epimerisation of trimethyl δ-arabonolactone into trimethyl δ-ribonolactone apparently takes place only with great difficulty.The structure of sedosan is found to be in harmony with its lack of tendency towards polymerization, and this is in accordance with the views of Hibbert on the relation of structure to polymerization.

Measurement and Correlation for Solubilities of Adipic Acid, Glutaric Acid and Succinic Acid in Acetic Acid + Cyclohexanone Mixtures

2017 ◽  
Vol 62 (4) ◽  
pp. 1269-1277 ◽  
Author(s):  
Weiping Luo ◽  
Xiuqing Li ◽  
Dong Ruan ◽  
Dawei Liu ◽  
Kaili Xie ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Succinic Acid ◽  
Adipic Acid ◽  
Glutaric Acid

Solubilities of Adipic Acid and Succinic Acid in a Glutaric Acid + Acetone or n-Butanol Mixture

2014 ◽  
Vol 59 (12) ◽  
pp. 4062-4069 ◽  
Author(s):  
Yanyan Li ◽  
Yatao Wang ◽  
Zhuoyuan Ning ◽  
Jianfang Cui ◽  
Qiaoye Wu ◽  
...  
Keyword(s):  
Succinic Acid ◽  
Adipic Acid ◽  
Glutaric Acid

New multi-component solid forms of anti-cancer drug Erlotinib: role of auxiliary interactions in determining a preferred conformation

2016 ◽  
Vol 72 (3) ◽  
pp. 291-300 ◽  
Author(s):  
Palash Sanphui ◽  
Lalit Rajput ◽  
Shanmukha Prasad Gopi ◽  
Gautam R Desiraju
Keyword(s):  
Succinic Acid ◽  
Adipic Acid ◽  
Glutaric Acid ◽  
Binary Systems ◽  
Active Pharmaceutical Ingredient ◽  
Cancer Drug ◽  
Wet Granulation ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Self Recognition

Erlotinib is a BCS (biopharmaceutical classification system) class II drug used for the treatment of non-small cell lung cancer. There is an urgent need to obtain new solid forms of higher solubility to improve the bioavailability of the API (active pharmaceutical ingredient). In this context, cocrystals with urea, succinic acid, and glutaric acid and salts with maleic acid, adipic acid, and saccharin were preparedviawet granulation and solution crystallizations. Crystal structures of the free base (Z′ = 2), cocrystals of erlotinib–urea (1:1), erlotinib–succinic acid monohydrate (1:1:1), erlotinib–glutaric acid monohydrate (1:1:1) and salts of erlotinib–adipic acid adipate (1:0.5:0.5) are determined and their hydrogen-bonding patterns are analyzed. Self recognitionviathe (amine) N—H...N (pyridine) hydrogen bond between the API molecules is replaced by several heterosynthons such as acid–pyridine, amide–pyridine and carboxylate–pyridinium in the new binary systems. Auxiliary interactions play an important role in determining the conformation of the API in the crystal. FT–IR spectroscopy is used to distinguish between the salts and cocrystals in the new multi-component systems. The new solid forms are characterized by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) to confirm their unique phase identity.

scholarly journals REACTIVE EXTRACTION OF DICARBOXYLIC ACIDS I. MECHANISM, LIMITING STEPS AND KINETICS

1997 ◽  
Vol 5 (5) ◽  
pp. 97-110
Author(s):  
Dan Cascaval ◽  
Radu Tudose ◽  
Comeliu Oniscu
Keyword(s):  
Mass Transfer ◽  
Oxalic Acid ◽  
Succinic Acid ◽  
Transfer Process ◽  
Adipic Acid ◽  
Glutaric Acid ◽  
Butyl Acetate ◽  
Dicarboxylic Acids ◽  
Mass Transfer Process ◽  
Reactive Extraction

In this paper the reactive extraction of some dicarboxylic acids (oxalic acid, malonic acid, succinic acid, glutaric acid, and adipic acid) have been studied. These acids have been extracted by Amberlite LA-2 in butyl acetate using a modified extraction cell of the Lewis type. Mechanism, limiting steps, and kinetic of the mass transfer process have been settled.

Measurement and Correlation for the Solubility of Adipic Acid and Succinic Acid in Glutaric Acid + Cyclohexanone and Glutaric Acid + Acetic Acid Mixtures

2017 ◽  
Vol 62 (10) ◽  
pp. 3473-3482 ◽  
Author(s):  
Xiangji Liao ◽  
Xiuqing Li ◽  
Yujun Han ◽  
Jun Song ◽  
Yingjie Gao ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Succinic Acid ◽  
Adipic Acid ◽  
Glutaric Acid
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