Photochemistry of caged molecules: CD3Cl@Ice

2003 ◽  
Vol 119 (1) ◽  
pp. 407-412 ◽  
Author(s):  
Y. Lilach ◽  
M. Asscher
Keyword(s):  
Caged Molecules

scholarly journals Mitochondria-specific photoactivation to monitor local sphingosine metabolism and function

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Suihan Feng ◽  
Takeshi Harayama ◽  
Sylvie Montessuit ◽  
Fabrice PA David ◽  
Nicolas Winssinger ◽  
...  
Keyword(s):  
Time Course ◽  
Random Distribution ◽  
Direct Evidence ◽  
Subcellular Location ◽  
Sphingolipid Metabolism ◽  
Powerful Approach ◽  
Sphingosine 1 Phosphate ◽  
Sphingosine Kinases ◽  
And Function ◽  
Caged Molecules

Photoactivation ('uncaging’) is a powerful approach for releasing bioactive small-molecules in living cells. Current uncaging methods are limited by the random distribution of caged molecules within cells. We have developed a mitochondria-specific photoactivation method, which permitted us to release free sphingosine inside mitochondria and thereafter monitor local sphingosine metabolism by lipidomics. Our results indicate that sphingosine was quickly phosphorylated into sphingosine 1-phosphate (S1P) driven by sphingosine kinases. In time-course studies, the mitochondria-specific uncaged sphingosine demonstrated distinct metabolic patterns compared to globally-released sphingosine, and did not induce calcium spikes. Our data provide direct evidence that sphingolipid metabolism and signaling are highly dependent on the subcellular location and opens up new possibilities to study the effects of lipid localization on signaling and metabolic fate.

New method for adding reagents: an application of caged molecules to analytical chemistry

2000 ◽  
Vol 405 (1-2) ◽  
pp. 17-21 ◽  
Author(s):  
Hirofumi Shiono ◽  
Hitoshi Nohta ◽  
Chika Utsuyama ◽  
Mitsuo Hiramatsu
Keyword(s):  
Analytical Chemistry ◽  
New Method ◽  
Caged Molecules

Resonances in inner-shell photoemission from caged molecules

2014 ◽  
Vol 196 ◽  
pp. 71-74 ◽  
Author(s):  
X.O. Brykalova ◽  
D.A. Rostov ◽  
Yu.S. Krivosenko ◽  
A.A. Pavlychev
Keyword(s):  
Caged Molecules

scholarly journals High-Energy Nitramine Explosives: A Design Strategy from Linear to Cyclic to Caged Molecules

ACS Omega ◽  
2018 ◽  
Vol 3 (8) ◽  
pp. 9739-9745 ◽  
Author(s):  
Junqing Yang ◽  
Guixiang Wang ◽  
Xuedong Gong ◽  
Jianguo Zhang ◽  
Yan Alexander Wang
Keyword(s):  
Design Strategy ◽  
High Energy ◽  
Caged Molecules

scholarly journals Ncm, a Photolabile Group for Preparation of Caged Molecules: Synthesis and Biological Application

PLoS ONE ◽  
2016 ◽  
Vol 11 (10) ◽  
pp. e0163937 ◽  
Author(s):  
Sukumaran Muralidharan ◽  
Nathaniel D. A. Dirda ◽  
Elizabeth J. Katz ◽  
Cha-Min Tang ◽  
Sharba Bandyopadhyay ◽  
...  
Keyword(s):  
Biological Application ◽  
Caged Molecules

Caged Molecules: Principles and Practical Considerations

2006 ◽  
Vol 37 (1) ◽  
pp. 6.20.1-6.20.21 ◽  
Author(s):  
Joseph P.Y. Kao
Keyword(s):  
Caged Molecules
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