Polarization dynamics in a ferroelectric relaxor excited by short pulses

2003 ◽  
Vol 82 (15) ◽  
pp. 2500-2502
Author(s):  
I. Boscolo ◽  
S. Cialdi
Keyword(s):  
Short Pulses ◽  
Ferroelectric Relaxor

Anomalous transmission of high contrast relativistically intense short pulses through thin metal foils

2006 ◽  
Vol 133 ◽  
pp. 511-514
Author(s):  
T. Matsuoka ◽  
A. Maksimchuk ◽  
T. Lin ◽  
O. V. Batishchev ◽  
A. A. Batishcheva ◽  
...  
Keyword(s):  
Thin Metal ◽  
High Contrast ◽  
Short Pulses ◽  
Metal Foils ◽  
Anomalous Transmission

scholarly journals Corona and polio viruses are sensitive to short pulses of W-band gyrotron radiation

2021 ◽  
Author(s):  
Lukasz S. Kaczmarczyk ◽  
Katherine S. Marsay ◽  
Sergey Shevchenko ◽  
Moritz Pilossof ◽  
Nehora Levi ◽  
...  
Keyword(s):  
Short Pulses ◽  
W Band

waveRAPID—A Robust Assay for High-Throughput Kinetic Screens with the Creoptix WAVEsystem

2021 ◽  
pp. 247255522110138
Author(s):  
Önder Kartal ◽  
Fabio Andres ◽  
May Poh Lai ◽  
Rony Nehme ◽  
Kaspar Cottier
Keyword(s):  
Drug Discovery ◽  
Fold Increase ◽  
Microtiter Plate ◽  
Experimental Conditions ◽  
Short Pulses ◽  
Cycle Times ◽  
Fragment Screening ◽  
New Instrument ◽  
Single Well ◽  
Compound Screening

Surface-based biophysical methods for measuring binding kinetics of molecular interactions, such as surface plasmon resonance (SPR) or grating-coupled interferometry (GCI), are now well established and widely used in drug discovery. Increasing throughput is an often-cited need in the drug discovery process and this has been achieved with new instrument generations where multiple interactions are measured in parallel, shortening the total measurement times and enabling new application areas within the field. Here, we present the development of a novel technology called waveRAPID for a further—up to 10-fold—increase in throughput, consisting of an injection method using a single sample. Instead of sequentially injecting increasing analyte concentrations for constant durations, the analyte is injected at a single concentration in short pulses of increasing durations. A major advantage of the new method is its ability to determine kinetics from a single well of a microtiter plate, making it uniquely suitable for kinetic screening. We present the fundamentals of this approach using a small-molecule model system for experimental validation and comparing kinetic parameters to traditional methods. By varying experimental conditions, we furthermore assess the robustness of this new technique. Finally, we discuss its potential for improving hit quality and shortening cycle times in the areas of fragment screening, low-molecular-weight compound screening, and hit-to-lead optimization.

Single-Shot Full-Field Characterization of Short Pulses by Using Temporal Annealing Modified Gerchberg–Saxton Algorithm

2017 ◽  
Vol 35 (13) ◽  
pp. 2541-2547 ◽  
Author(s):  
Zhi Qiao ◽  
Yudong Yao ◽  
Xiaochao Wang ◽  
Wei Fan ◽  
Zunqi Lin
Keyword(s):  
Single Shot ◽  
Short Pulses ◽  
Full Field
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