Double tuned 23Na 1H nuclear magnetic resonance birdcage for application on mice in vivo

2001 ◽  
Vol 72 (5) ◽  
pp. 2508-2510 ◽  
Author(s):  
Titus Lanz ◽  
Jan Ruff ◽  
Alexander Weisser ◽  
Axel Haase
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
1H Nuclear Magnetic Resonance ◽  
Nuclear Magnetic

scholarly journals Intracellular Metabolites in Rat Muscle following Trauma: A 31P and 1H Nuclear Magnetic Resonance Study

1987 ◽  
Vol 80 (8) ◽  
pp. 495-498 ◽  
Author(s):  
D B Sprague ◽  
D G Gadian ◽  
S R Williams ◽  
E Proctor ◽  
A W Goode
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Nmr Spectroscopy ◽  
Magnetic Resonance ◽  
Nuclear Magnetic Resonance Study ◽  
Control Group ◽  
1H Nuclear Magnetic Resonance ◽  
Trauma Model ◽  
Experimental Group ◽  
Nuclear Magnetic

Hind limb skeletal muscle was studied in vivo in a rat trauma model using nuclear magnetic resonance (NMR) spectroscopy. The model used was a 25% body surface area, full-thickness burn administered under anaesthesia. Two groups of six rats were studied. Weight loss was observed in the experimental group whilst the control group continued to gain weight. Concentration ratios involving intramyocellular phosphocreatine (PCr), creatine (Cr), adenosine triphosphate (ATP), inorganic phosphate (Pi), anserine (Ans) and taurine (Tau) were measured. No change in the ratios of PCr/Pi, PCr/ATP, Ans/PCr + Cr and Tau/PCr + Cr were seen between the two groups. Intracellular pH was the same in the two groups. NMR spectroscopy in vivo gives values of Pi and PCr that differ from those obtained by conventional techniques. NMR values are probably more accurate as no degradation occurs during measurement, the measurements being repeatable and noninvasive.

1H nuclear-magnetic-resonance studies of muscle metabolism in vivo

1985 ◽  
Vol 13 (5) ◽  
pp. 839-842 ◽  
Author(s):  
S. R. WILLIAMS ◽  
D. G. GADIAN ◽  
E. PROCTOR ◽  
D. B. SPRAGUE ◽  
D. F. TALBOT ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Muscle Metabolism ◽  
Magnetic Resonance Studies ◽  
1H Nuclear Magnetic Resonance ◽  
Nuclear Magnetic

1H-nuclear magnetic resonance deoxymyoglobin signal as indicator of intracellular oxygenation in myocardium

1991 ◽  
Vol 261 (6) ◽  
pp. H2091-H2097 ◽  
Author(s):  
U. Kreutzer ◽  
T. Jue
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Tissue Oxygenation ◽  
Perfused Heart ◽  
Oxidative Energy Metabolism ◽  
1H Nuclear Magnetic Resonance ◽  
Tissue Region ◽  
The One ◽  
Nuclear Magnetic

We report in this study that the intracellular oxygenation state is measurable with the 1H nuclear magnetic resonance signal of the proximal histidine N delta H proton of deoxymyoglobin. The signal appears in a clear spectral region of the 1H spectrum and is sensitive to various hypoxic and ischemic conditions. In perfused heart, the deoxymyoglobin's response to tissue oxygenation precedes the one reflected in the 31P phosphocreatine or ATP signals, suggesting that oxidative energy metabolism is still sufficient even when the myoglobin is partially saturated with oxygen. Our method offers then a unique way to observe tissue oxygenation and its interaction in localized tissue region in vivo.

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