Resolution limits for infrared microspectroscopy explored with synchrotron radiation

2001 ◽  
Vol 72 (3) ◽  
pp. 1613 ◽  
Author(s):  
G. L. Carr
2015 ◽  
Vol 35 (4) ◽  
pp. 0430002
Author(s):  
朱化春 Zhu Huachun ◽  
佟亚军 Tong Yajun ◽  
吉特 Ji Te ◽  
彭蔚蔚 Peng Weiwei ◽  
张增艳 Zhang Zengyan ◽  
...  

1992 ◽  
Vol 63 (1) ◽  
pp. 1551-1554 ◽  
Author(s):  
A. Ugawa ◽  
H. Ishii ◽  
K. Yakushi ◽  
H. Okamoto ◽  
T. Mitani ◽  
...  

2012 ◽  
Vol 65 (3) ◽  
pp. 204 ◽  
Author(s):  
Carolyn Therese Dillon

This review updates the recent advances and applications of three prominent synchrotron radiation techniques, microprobe X-ray fluorescence spectroscopy/imaging, X-ray absorption spectroscopy, and infrared microspectroscopy, and highlights how these tools are useful to the medicinal chemist. A brief description of the principles of the techniques is given with emphasis on the advantages of using synchrotron radiation-based instrumentation rather than instruments using typical laboratory radiation sources. This review focuses on several recent applications of these techniques to solve inorganic medicinal chemistry problems, focusing on studies of cellular uptake, distribution, and biotransformation of established and potential therapeutic agents. The importance of using these synchrotron-based techniques to assist the development of, or validate the chemistry behind, drug design is discussed.


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