A simple setup to simultaneously measure the resonant frequency and the absolute dissipation factor of a quartz crystal microbalance

1996 ◽  
Vol 67 (9) ◽  
pp. 3238-3241 ◽  
Author(s):  
Michael Rodahl ◽  
Bengt Kasemo
Keyword(s):  
Resonant Frequency ◽  
Quartz Crystal Microbalance ◽  
Quartz Crystal ◽  
Dissipation Factor ◽  
The Absolute

scholarly journals Determination of surface-induced platelet activation by applying time-dependency dissipation factor versus frequency using quartz crystal microbalance with dissipation

2011 ◽  
Vol 8 (60) ◽  
pp. 988-997 ◽  
Author(s):  
Julien Fatisson ◽  
Sania Mansouri ◽  
Daniel Yacoub ◽  
Yahye Merhi ◽  
Maryam Tabrizian
Keyword(s):  
Platelet Activation ◽  
Quartz Crystal Microbalance ◽  
Quartz Crystal ◽  
Dissipation Factor ◽  
Surface Hydrophobicity ◽  
Activation Rate ◽  
Immunofluorescence Labelling ◽  
Activation Rates

Platelet adhesion and activation rates are frequently used to assess the thrombogenicity of biomaterials, which is a crucial step for the development of blood-contacting devices. Until now, electron and confocal microscopes have been used to investigate platelet activation but they failed to characterize this activation quantitatively and in real time. In order to overcome these limitations, quartz crystal microbalance with dissipation (QCM-D) was employed and an explicit time scale introduced in the dissipation versus frequency plots ( Df–t ) provided us with quantitative data at different stages of platelet activation. The QCM-D chips were coated with thrombogenic and non-thrombogenic model proteins to develop the methodology, further extended to investigate polymer thrombogenicity. Electron microscopy and immunofluorescence labelling were used to validate the QCM-D data and confirmed the relevance of Df–t plots to discriminate the activation rate among protein-modified surfaces. The responses showed the predominant role of surface hydrophobicity and roughness towards platelet activation and thereby towards polymer thrombogenicity. Modelling experimental data obtained with QCM-D with a Matlab code allowed us to define the rate at which mass change occurs ( A / B ), to obtain an A / B value for each polymer and correlate this value with polymer thrombogenicity.

scholarly journals Response of Quartz Crystal Microbalance Loaded with Single-drop Liquid in Gas Phase

2014 ◽  
Vol 8 (1) ◽  
pp. 197-201
Author(s):  
Li Yang ◽  
Xianhe Huang
Keyword(s):  
Resonant Frequency ◽  
Quartz Crystal Microbalance ◽  
Quartz Crystal ◽  
Liquid Droplet ◽  
Theoretical Formula ◽  
Frequency Change ◽  
Single Drop ◽  
The Relationship ◽  
Liquid Property ◽  
Repeated Experiment

The frequency response of quartz crystal microbalance loaded by single-drop liquid is studied in this paper. Previous studies have shown that the relationship between resonant frequency and properties of liquid by completely immersing one side of the crystal in liquid. In this work, only localized portion of crystal was wetted by liquid droplet. Repeated experiment shows the relationship between liquid property include viscosity and density to resonant frequency. Furthermore, Theoretical formula describing the frequency change of the quartz crystal microbalance with liquid property is proposed. The predicted results showed distinct coincide with experimental results.

scholarly journals Changes of Viscoelastic Properties of Aptamer-Based Sensing Layers Following Interaction with Listeria innocua

Sensors ◽  
2021 ◽  
Vol 21 (16) ◽  
pp. 5585
Author(s):  
Marek Tatarko ◽  
Sandro Spagnolo ◽  
Veronika Oravczová ◽  
Judit Süle ◽  
Milan Hun ◽  
...  
Keyword(s):  
Protein Structure ◽  
Shear Modulus ◽  
Resonant Frequency ◽  
Penetration Depth ◽  
Quartz Crystal Microbalance ◽  
Viscoelastic Properties ◽  
Quartz Crystal ◽  
Viscosity Coefficient ◽  
Listeria Innocua ◽  
E Coli

A multiharmonic quartz crystal microbalance (QCM) has been applied to study the viscoelastic properties of the aptamer-based sensing layers at the surface of a QCM transducer covered by neutravidin following interaction with bacteria Listeria innocua. Addition of bacteria in the concentration range 5 × 103–106 CFU/mL resulted in a decrease of resonant frequency and in an increase of dissipation. The frequency decrease has been lower than one would expect considering the dimension of the bacteria. This can be caused by lower penetration depth of the acoustics wave (approximately 120 nm) in comparison with the thickness of the bacterial layer (approximately 500 nm). Addition of E. coli at the surface of neutravidin as well as aptamer layers did not result in significant changes in frequency and dissipation. Using the Kelvin–Voight model the analysis of the viscoelastic properties of the sensing layers was performed and several parameters such as penetration depth, Γ, viscosity coefficient, η, and shear modulus, μ, were determined following various modifications of QCM transducer. The penetration depth decreased following adsorption of the neutravidin layer, which is evidence of the formation of a rigid protein structure. This value did not change significantly following adsorption of aptamers and Listeria innocua. Viscosity coefficient was higher for the neutravidin layer in comparison with the naked QCM transducer in a buffer. However, a further increase of viscosity coefficient took place following attachment of aptamers suggesting their softer structure. The interaction of Listeria innocua with the aptamer layer resulted in slight decrease of viscosity coefficient. The shearing modulus increased for the neutravidin layer and decreased following aptamer adsorption, while a slight increase of µ was observed after the addition of Listeria innocua.

scholarly journals Blood Coagulation Testing Smartphone Platform Using Quartz Crystal Microbalance Dissipation Method

Sensors ◽  
2018 ◽  
Vol 18 (9) ◽  
pp. 3073 ◽  
Author(s):  
Jia Yao ◽  
Bin Feng ◽  
Zhiqi Zhang ◽  
Chuanyu Li ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Quartz Crystal Microbalance ◽  
Quartz Crystal ◽  
Clinical Laboratory ◽  
Point Of Care ◽  
Dissipation Factor ◽  
Parylene C ◽  
Adhesive Surface ◽  
Self Testing ◽  
Coagulation Testing

Blood coagulation function monitoring is important for people who are receiving anticoagulation treatment and a portable device is needed by these patients for blood coagulation self-testing. In this paper, a novel smartphone based blood coagulation test platform was proposed. It was developed based on parylene-C coated quartz crystal microbalance (QCM) dissipation measuring and analysis. The parylene-C coating constructed a robust and adhesive surface for fibrin capturing. The dissipation factor was obtained by measuring the frequency response of the sensor. All measured data were sent to a smartphone via Bluetooth for dissipation calculation and blood coagulation results computation. Two major coagulation indexes, activated partial thromboplastin time (APTT) and prothrombin time (PT) were measured on this platform compared with results by a commercial hemostasis system in a clinical laboratory. The measurement results showed that the adjusted R-square (R2) value for APTT and PT measurements were 0.985 and 0.961 respectively. The QCM dissipation method for blood coagulation measurement was reliable and effective and the platform together with the QCM dissipation method was a promising solution for point of care blood coagulation testing.

scholarly journals Vaporization Thermodynamics of Pyrrolidinium, Pyridinium, and Imidazolium-Based Ionic Liquids Bearing the Bis(fluorosulfonyl)imide [FSI] and the Bis(trifluoromethylsulfonyl)imide [NTf2] Anions

2022 ◽  
Vol 43 (2) ◽  
Author(s):  
Dzmitry H. Zaitsau ◽  
Sergey P. Verevkin
Keyword(s):  
Ionic Liquids ◽  
Quartz Crystal Microbalance ◽  
Quartz Crystal ◽  
Chemical Engineering ◽  
Vaporization Enthalpy ◽  
Vapor Pressures ◽  
The Absolute ◽  
Separation Media

AbstractNew experimental vapor pressures in the range 407 K to 460 K and vaporization enthalpy of the ionic liquids (IL) N-alkyl-N-methyl-pyrrolidinium bis(fluorosulfonyl)imide ionic liquids have been measured using quartz crystal microbalance. The absolute vapor pressures and vaporization enthalpies were compared with analogous pyrrolidinium-based ILs with the bis(trifluoromethanesulfonyl)imide anion. The evaluated difference in vaporization enthalpy of ILs with bis(fluorosulfonyl)imide and bis(trifluoromethanesulfonyl)imide anions allowed for estimation of corresponding property for a wide set of ILs with bis(fluorosulfonyl)imide anion. The results are relevant to chemical engineering calculations of processes involving ILs as reaction and separation media.

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