Long-Term Vasodilator Therapy in Patients with Severe Aortic Regurgitation

2005 ◽  
Vol 353 (13) ◽  
pp. 1342-1349 ◽  
Author(s):  
Artur Evangelista ◽  
Pilar Tornos ◽  
Antonia Sambola ◽  
Gaietà Permanyer-Miralda ◽  
Jordi Soler-Soler
Keyword(s):  
Aortic Regurgitation ◽  
Vasodilator Therapy ◽  
Severe Aortic Regurgitation

Effects of long-term vasodilator therapy on electrocardiographic abnormalities in chronic aortic regurgitation

1991 ◽  
Vol 68 (9) ◽  
pp. 935-939 ◽  
Author(s):  
Richard Wilson ◽  
Neal Perlmutter ◽  
Nils Jacobson ◽  
Deirdre Siemienczuk ◽  
Jadwiga Szlachcic ◽  
...  
Keyword(s):  
Aortic Regurgitation ◽  
Vasodilator Therapy ◽  
Chronic Aortic Regurgitation ◽  
Electrocardiographic Abnormalities

Different treatment options for Takayasu arteritis patients with moderate-to-severe aortic regurgitation: long-term outcomes

Rheumatology ◽  
2020 ◽  
Author(s):  
Xuesen Cheng ◽  
Zuozhi Li ◽  
Aimin Dang ◽  
Naqiang Lv ◽  
Qian Chang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Conservative Treatment ◽  
Aortic Regurgitation ◽  
Takayasu Arteritis ◽  
Baseline Risk ◽  
Long Term Outcomes ◽  
End Points ◽  
Severe Aortic Regurgitation ◽  
All Cause Mortality

Abstract Objectives To determine the prognosis of Takayasu arteritis (TA) patients with moderate-to-severe aortic regurgitation treated with surgical vs conservative treatment and to identify independent prognostic factors of long-term outcomes. Methods Between January 2002 and January 2017, 101 consecutive TA patients with moderate-to-severe aortic regurgitation treated with either surgical (n = 38) or conservative (n = 63) treatments were investigated in this retrospective observational case–control study. The primary end point was all-cause mortality, and the secondary end point comprised the combined end points of death, non-fatal stroke and cardiac events (non-fatal myocardial infarction and congestive heart failure). Propensity score matching was used to reduce the bias of baseline risk factors. Results The unadjusted all-cause 10-year mortality in the conservative group was increased compared with the surgical group (28.2% vs 7.4%; log-rank P = 0.036), and the combined end points showed the same trend (52.1% vs 25.3%; log-rank P = 0.005). After an adjustment of baseline risk factors, the conservative treatment was associated with reduced survival rates of both all-cause mortality [hazard ratio (HR): 8.243; 95% CI: 1.069, 63.552; P = 0.007] and combined end points (HR: 6.341; 95% CI: 1.469, 27.375; P = 0.002). Conservative treatment (HR: 3.838, 95% CI: 1.333, 11.053; P = 0.013) and left ventricular end-diastolic diameter (HR: 1.036, 95% CI: 1.001, 1.071; P = 0.042) were risk factors for increased combined end points. Conclusion Surgical treatment improves the outcomes of patients with moderate-to-severe aortic regurgitation due to TA. The dilated left ventricle indicated a worse prognosis.

scholarly journals Long-term nifedipine unloading therapy in asymptomatic patients with chronic severe aortic regurgitation

1990 ◽  
Vol 16 (2) ◽  
pp. 424-429 ◽  
Author(s):  
Roldano Scognamiglio ◽  
Giuseppe Fasoli ◽  
Andrea Ponchia ◽  
Sergio Dalla-Volta
Keyword(s):  
Aortic Regurgitation ◽  
Severe Aortic Regurgitation ◽  
Asymptomatic Patients

scholarly journals Aortic valve neocuspidization with in-body tissue-engineered autologous membranes: preliminary results in a long-term goat model

2021 ◽  
Author(s):  
Takayuki Kawashima ◽  
Tadashi Umeno ◽  
Takeshi Terazawa ◽  
Tomoyuki Wada ◽  
Takashi Shuto ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Regurgitation ◽  
Young Patients ◽  
High Rate ◽  
Body Tissue ◽  
Histological Evaluation ◽  
Long Term Outcome ◽  
Severe Aortic Regurgitation ◽  
Autologous Pericardium

Abstract OBJECTIVES Aortic valve neocuspidization has shown satisfactory clinical outcomes; however, autologous pericardium durability is a concern for young patients. This study applied an autologous collagenous membrane (Biosheet®), produced by in-body tissue architecture, to aortic valve neocuspidization and investigated its long-term outcome in a goat model. METHODS Moulds were embedded subcutaneously in 6 goats. After 2 months, Biosheets formed in the moulds. We performed aortic valve neocuspidization using a portion of the sheets with a thickness of 0.20–0.35 mm, measured by optical coherence tomography. Animals were subjected to echocardiography and histological evaluation at 6 months (n = 3) and 12 months (n = 3). As a control, the glutaraldehyde-treated autologous pericardium was used in 4 goats that were similarly evaluated at 12 months. RESULTS All animals survived the scheduled period. At 6 months, Biosheets maintained valve function and showed a regeneration response: fusion to the annulus, cell infiltration to the leaflets and appearance of elastic fibres at the ventricular side. After 12 months, the regenerative structure had changed little without regression, and there was negligible calcification in the 1/9 leaflets. However, all cases had one leaflet tear, resulting in moderate-to-severe aortic regurgitation. In the pericardium group, three-fourths of the animals experienced moderate-to-severe aortic regurgitation with a high rate of calcification (9/12 leaflets). CONCLUSIONS Biosheets may have regeneration potential and anti-calcification properties in contrast to autologous pericardium. However, in order to obtain reliable outcome, further improvements are required to strictly control and optimize its thickness, density and homogeneity.

Sign in / Sign up

Export Citation Format

Share Document