Aspirin, COX-2, and the Risk of Colorectal Cancer

2007 ◽  
Vol 357 (8) ◽  
pp. 824-825 ◽  
Keyword(s):  
Colorectal Cancer ◽  
Cox 2

scholarly journals Cyclooxygenase-2 (COX-2) Expression in a Cohort of Greek Patients with Colorectal Cancer (CRC)

2014 ◽  
Vol 25 ◽  
pp. ii75
Author(s):  
Tzilves Dimitrios ◽  
Patakiouta Frinda ◽  
Pilpilidis Ioannis ◽  
Lazaraki Georgia ◽  
Xiroy Persefoni ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cyclooxygenase 2 ◽  
Cox 2

scholarly journals Over-expression of COX-2 mRNA in colorectal cancer

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Hennie MJ Roelofs ◽  
Rene HM te Morsche ◽  
Bjorn WH van Heumen ◽  
Fokko M Nagengast ◽  
Wilbert HM Peters
Keyword(s):  
Colorectal Cancer ◽  
Over Expression ◽  
Cox 2

Cyclooxygenase (COX)-2 immunoreactivity and relationship to p53 and Ki-67 expression in colorectal cancer

1999 ◽  
Vol 34 (2) ◽  
pp. 189-194 ◽  
Author(s):  
Kazuhiro Sakuma ◽  
Takahiro Fujimori ◽  
Kaoru Hirabayashi ◽  
Akira Terano
Keyword(s):  
Colorectal Cancer ◽  
Ki 67 ◽  
Cox 2

EGFR, HER-2 and COX-2 levels in colorectal cancer

2008 ◽  
Vol 53 (6) ◽  
pp. 698-706 ◽  
Author(s):  
A G Antonacopoulou ◽  
A C Tsamandas ◽  
T Petsas ◽  
A Liava ◽  
C D Scopa ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Her 2 ◽  
Cox 2

scholarly journals Time-serial Assessment of Drug Combination Interventions in a Mouse Model of Colorectal Carcinogenesis Using Optical Coherence Tomography

2015 ◽  
Vol 8s1 ◽  
pp. CGM.S21216 ◽  
Author(s):  
Susan LeGendre-McGhee ◽  
Photini S. Rice ◽  
R. Andrew Wall ◽  
Kyle J. Sprute ◽  
Ramireddy Bommireddy ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Growth Rate ◽  
Optical Coherence Tomography ◽  
Mouse Model ◽  
Tumor Burden ◽  
Colorectal Carcinogenesis ◽  
Optical Coherence ◽  
Ki 67 ◽  
Tumor Number ◽  
Cox 2

Optical coherence tomography (OCT) is a high-resolution, nondestructive imaging modality that enables time-serial assessment of adenoma development in the mouse model of colorectal cancer. In this study, OCT was utilized to evaluate the effectiveness of interventions with the experimental antitumor agent α-difluoromethylornithine (DFMO) and a nonsteroidal anti-inflammatory drug sulindac during early [chemoprevention (CP)] and late stages [chemotherapy (CT)] of colon tumorigenesis. Biological endpoints for drug interventions included OCT-generated tumor number and tumor burden. Immunochistochemistry was used to evaluate biochemical endpoints [Ki-67, cleaved caspase-3, cyclooxygenase (COX)-2, β-catenin]. K-Ras codon 12 mutations were studied with polymerase chain reaction-based technique. We demonstrated that OCT imaging significantly correlated with histological analysis of both tumor number and tumor burden for all experimental groups ( P < 0.0001), but allows more accurate and full characterization of tumor number and burden growth rate because of its time-serial, nondestructive nature. DFMO alone or in combination with sulindac suppressed both the tumor number and tumor burden growth rate in the CP setting because of DFMO-mediated decrease in cell proliferation (Ki-67, P < 0.001) and K-RAS mutations frequency ( P = 0.04). In the CT setting, sulindac alone and DFMO/sulindac combination were effective in reducing tumor number, but not tumor burden growth rate. A decrease in COX-2 staining in DFMO/sulindac CT groups (COX-2, P < 0.01) confirmed the treatment effect. Use of nondestructive OCT enabled repeated, quantitative evaluation of tumor number and burden, allowing changes in these parameters to be measured during CP and as a result of CT. In conclusion, OCT is a robust minimally invasive method for monitoring colorectal cancer disease and effectiveness of therapies in mouse models.

Resveratrol and Colorectal Cancer: A Molecular Approach to Clinical Researches

2021 ◽  
Vol 21 ◽  
Author(s):  
Eisa Kaveh Vernousfaderani ◽  
Negin Akhtari ◽  
Sara Rezaei ◽  
Yasaman Rezaee ◽  
Saba Shiranirad ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Pentose Phosphate Pathway ◽  
Clinical Studies ◽  
Pentose Phosphate ◽  
Pharmacological Effects ◽  
Molecular Approach ◽  
Prevention And Treatment ◽  
Cox 2

: Phytochemicals are the most valuable and comprehensive structures, which may have a broad range of protective benefits, from reducing inflammation and speeding healing to preventing infection and fighting cancer. Resveratrol (RSV) is a natural phenolic compound from the oligomeric stilbenoid group, which is usually found in human daily diets such as grape, peanut, berries and grains. It exhibits anti-inflammatory, neuroprotection, antioxidant and cancer prevention and treatment effects. RSV is thought to have an impressive outcome in colorectal cancer (CRC) treatment through the vital molecules and cancer signaling pathways, including SIRT1, P53, P21, AMPK, ROS, BMP7, COX-2, NO, Caspases, Wnt, TNFs, NF-κB, EMT, and pentose phosphate pathway. Therefore, this paper reviews the current researches on resveratrol pharmacological effects and pharmacokinetic and drug delivery system, as well as clinical studies in CRC.

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