Neuroprotective Effect of Deep Hypothermic Circulatory Arrest with Low Priming Volume: Study in a Rabbit Model

2008 ◽  
Vol 56 (3) ◽  
pp. 133-139 ◽  
Author(s):  
X. Pan ◽  
L. Sun ◽  
W. Ma ◽  
L. Tian ◽  
N. Liu ◽  
...  
Keyword(s):  
Neuroprotective Effect ◽  
Circulatory Arrest ◽  
Rabbit Model ◽  
Deep Hypothermic Circulatory Arrest ◽  
Hypothermic Circulatory Arrest ◽  
Priming Volume

scholarly journals The deep hypothermic circulatory arrest causes more kidney malfunctions based on a novel rabbit model

2014 ◽  
Vol 34 (6) ◽  
pp. 532-540 ◽  
Author(s):  
Lei Yu ◽  
Tianxiang Gu ◽  
Guangwei Zhang ◽  
Shi Cheng ◽  
Qin Fang ◽  
...  
Keyword(s):  
Circulatory Arrest ◽  
Rabbit Model ◽  
Deep Hypothermic Circulatory Arrest ◽  
Hypothermic Circulatory Arrest

BRAIN TEMPERATURE DISTRIBUTION DURING DEEP HYPOTHERMIC CIRCULATORY ARREST IN HUMANS

2004 ◽  
Vol 04 (02) ◽  
pp. 197-212 ◽  
Author(s):  
O. LEY ◽  
Y. BAYAZITOGLU
Keyword(s):  
Temperature Distribution ◽  
Brain Temperature ◽  
Neuroprotective Effect ◽  
Circulatory Arrest ◽  
Deep Hypothermic Circulatory Arrest ◽  
Hypothermic Circulatory Arrest ◽  
Head Cooling ◽  
External Cooling ◽  
Before And After ◽  
Adults And Children

This paper analyzes the effect of different cooling and rewarming strategies on the brain temperature distribution before and after circulatory arrest in adults and children. The temperature variations during systemic cooling, circulatory arrest, and rewarming are calculated using a thermal model that incorporates physiological parameters. The calculations presented here explain why sometimes hypothermia does not show the expected neuroprotective effect.This work shows the importance of departing from a steady temperature distribution when using deep hypothermic circulatory arrest. In the calculations, the external cooling conditions of the head are varied, and it is observed that hypothermic cardiopulmonary bypass (CPB) together with external head cooling help reduce the temperature gradients within the head during periods of reduced blood flow, and reduces the temperature increase in the deep tissue produced by the residual cerebral metabolic activity. The results presented here agree with previous experimental observations1–3regarding the duration of systemic cooling using CPB.

Open Distal Anastomosis Technique for Ascending Aortic Aneurysm Repair without Cerebral Perfusion

2015 ◽  
Vol 18 (4) ◽  
pp. 124
Author(s):  
Mehmet Kaplan ◽  
Bahar Temur ◽  
Tolga Can ◽  
Gunseli Abay ◽  
Adlan Olsun ◽  
...  
Keyword(s):  
Aortic Aneurysm ◽  
Cerebral Perfusion ◽  
Circulatory Arrest ◽  
Deep Hypothermic Circulatory Arrest ◽  
Hypothermic Circulatory Arrest ◽  
Distal Anastomosis ◽  
Ascending Aortic Aneurysm ◽  
Aortic Aneurysm Surgery ◽  
Aneurysm Repair ◽  
Aortic Aneurysm Repair

<p><strong>Background</strong><strong>: </strong>This study aimed to report the outcomes of patients who underwent proximal thoracic aortic aneurysm surgery with open distal anastomosis technique but without cerebral perfusion, instead under deep hypothermic circulatory arrest.</p><p><strong>Methods: </strong>Thirty patients (21 male, 9 female) who underwent ascending aortic aneurysm repair with open distal anastomosis technique were included. The average age was 60.2±11.7 years. Operations were performed under deep hypothermic circulatory arrest and the cannulation for cardiopulmonary bypass was first done over the aneurysmatic segment and then moved over the graft. Intraoperative and early postoperative mortality and morbidity outcomes were reported.</p><p><strong>Results</strong><strong>: </strong>Average duration of cardiopulmonary bypass and cross-clamps were 210.8±43 and 154.9±35.4 minutes, respectively. Average duration of total circulatory arrest was 25.2±2.4 minutes. There was one hospital death (3.3%) due to chronic obstructive pulmonary disease at postoperative day 22. No neurological dysfunction was observed during the postoperative period.<strong></strong></p><p><strong>Conclusion: </strong>These results demonstrate that open distal anastomosis under less than 30 minutes of deep hypothermic circulatory arrest without antegrade or retrograde cerebral perfusion and cannulation of the aneurysmatic segment is a safe and reliable procedure in patients undergoing proximal thoracic aortic aneurysm surgery.</p><p> </p>

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