Metabolic Effects of Low-Dose Incremental Insulin Infusion in Diabetic Man

1986 ◽  
Vol 18 (02) ◽  
pp. 129-133 ◽  
Author(s):  
P. Hale ◽  
E. Black ◽  
M. Nattrass
Contraception ◽  
1989 ◽  
Vol 39 (6) ◽  
pp. 643-652 ◽  
Author(s):  
Roberto Miccoli ◽  
Maria Carmela Orlandi ◽  
Franca Fruzzetti ◽  
Ottavio Giampietro ◽  
Gianbenedetto Melis ◽  
...  
Keyword(s):  
Low Dose ◽  

1984 ◽  
Vol 105 (4) ◽  
pp. 515-520 ◽  
Author(s):  
G. C. Viberti ◽  
P. D. Home ◽  
R. W. Bilous ◽  
K. G. M. M. Alberti ◽  
N. Dalton ◽  
...  

Abstract. The metabolic and hormonal response to moderately severe exercise 2 h after breakfast was assessed in 8 insulin-dependent diabetics during conventional insulin injection therapy and after 3 weeks of continuous sc insulin infusion. Blood glucose fell from 12.1 to 4.4 mmol/l on injection therapy; this was accompanied by a significant rise (P < 0.05) in free insulin to 57 mU/l. On infusion therapy plasma glucose fell and stabilised at 3.6 mmol/l from pre-exercise levels of 7.1 mmol/l, while free insulin level was unchanged at the end of the exercise period (31 mU/l). The fall in blood glucose on injection therapy was accompanied by an exaggerated growth hormone response to exercise that was normalised by 3 weeks of infusion therapy. Basal and post-prandial levels of intermediary metabolites, catecholamines and glucagon were comparable on the two insulin regimens. Responses during exercise were generally similar and no different from those of normal subjects, with the exception of plasma NEFA levels which became abnormally suppressed. Good metabolic control of diabetes is thus accompanied by nearly normal hormonal and metabolic response to moderately severe exercise.


1977 ◽  
Vol 91 (5) ◽  
pp. 701-705 ◽  
Author(s):  
George A. Edwards ◽  
Edward C. Kohaut ◽  
Barbara Wehring ◽  
L. Leighton Hill

Author(s):  
L. De Cecco ◽  
G. L. Capitanio ◽  
S. Bertolini ◽  
S. Croce ◽  
A. Centonze

2001 ◽  
Vol 29 (3) ◽  
pp. 487-493 ◽  
Author(s):  
Isao Tsuneyoshi ◽  
Haruhiko Yamada ◽  
Yasuyuki Kakihana ◽  
Masataka Nakamura ◽  
Youichirou Nakano ◽  
...  

1977 ◽  
Vol 11 (4) ◽  
pp. 429-429
Author(s):  
Michael Nussbaum ◽  
Cyril A L Abrams ◽  
Ronald Shenker ◽  
Philip Lanzkowsky

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