Kupffer Cells: Their Activation and Role in Animal Models of Liver Injury and Human Liver Disease

1993 ◽  
Vol 13 (01) ◽  
pp. 50-59 ◽  
Author(s):  
Paul Winwood ◽  
Michael Arthur
Keyword(s):  
Liver Disease ◽  
Animal Models ◽  
Liver Injury ◽  
Kupffer Cells ◽  
Human Liver ◽  
Human Liver Disease

scholarly journals Iron-Induced Liver Injury: A Critical Reappraisal

2019 ◽  
Vol 20 (9) ◽  
pp. 2132 ◽  
Author(s):  
Steven A. Bloomer ◽  
Kyle E. Brown
Keyword(s):  
Liver Disease ◽  
Animal Models ◽  
Liver Injury ◽  
Iron Overload ◽  
Liver Damage ◽  
Human Liver ◽  
Hereditary Hemochromatosis ◽  
Hepatitis C Infection ◽  
Nonalcoholic Fatty Liver ◽  
Hepatocyte Necrosis

Iron is implicated in the pathogenesis of a number of human liver diseases. Hereditary hemochromatosis is the classical example of a liver disease caused by iron, but iron is commonly believed to contribute to the progression of other forms of chronic liver disease such as hepatitis C infection and nonalcoholic fatty liver disease. In this review, we present data from cell culture experiments, animal models, and clinical studies that address the hepatotoxicity of iron. These data demonstrate that iron overload is only weakly fibrogenic in animal models and rarely causes serious liver damage in humans, calling into question the concept that iron overload is an important cause of hepatotoxicity. In situations where iron is pathogenic, iron-induced liver damage may be potentiated by coexisting inflammation, with the resulting hepatocyte necrosis an important factor driving the fibrogenic response. Based on the foregoing evidence that iron is less hepatotoxic than is generally assumed, claims that assign a causal role to iron in liver injury in either animal models or human liver disease should be carefully evaluated.

scholarly journals Distinct structural and dynamic components of portal hypertension in different animal models and human liver disease etiologies

Hepatology ◽  
2021 ◽  
Author(s):  
Philipp Königshofer ◽  
Benedikt Silvester Hofer ◽  
Ksenia Brusilovskaya ◽  
Benedikt Simbrunner ◽  
Oleksandr Petrenko ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Liver Disease ◽  
Animal Models ◽  
Human Liver ◽  
Dynamic Components ◽  
Human Liver Disease

Keratins 8/18 represent type II acute-phase proteins which are differentially regulated in human liver disease

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
N Güldiken ◽  
V Usachov ◽  
K Levada ◽  
M Ziol ◽  
P Nahon ◽  
...  
Keyword(s):  
Liver Disease ◽  
Acute Phase ◽  
Human Liver ◽  
Acute Phase Proteins ◽  
Type Ii ◽  
Human Liver Disease

Serum Xanthine Oxidase in Human Liver Disease

2001 ◽  
Vol 96 (4) ◽  
pp. 1194-1199 ◽  
Author(s):  
Maria Giulia Battelli ◽  
Silvia Musiani ◽  
Marco Valgimigli ◽  
Laura Gramantieri ◽  
Federica Tomassoni ◽  
...  
Keyword(s):  
Liver Disease ◽  
Xanthine Oxidase ◽  
Human Liver ◽  
Human Liver Disease

Plasma lysozyme level and reticuloendothelial system function in human liver disease

1981 ◽  
Vol 113 (2) ◽  
pp. 193-199 ◽  
Author(s):  
Adrie CM. van Vliet ◽  
W.H. Bakker ◽  
J. Lindemans ◽  
J.H.P. Wilson ◽  
R.A.A. van Zanten
Keyword(s):  
Liver Disease ◽  
Human Liver ◽  
Reticuloendothelial System ◽  
System Function ◽  
Human Liver Disease

Role of BMP-9 in human liver disease

Gut ◽  
2018 ◽  
Vol 68 (11) ◽  
pp. 2097-2100 ◽  
Author(s):  
Miya John ◽  
Kyung-Jin Kim ◽  
Sarah Da Won Bae ◽  
Liang Qiao ◽  
Jacob George
Keyword(s):  
Liver Disease ◽  
Human Liver ◽  
Human Liver Disease

scholarly journals Lysosomes and Human Liver Disease: A Biochemical and Immunohistochemical Study of -Hexosaminidase

1994 ◽  
Vol 32 (9) ◽  
Author(s):  
M. E. Elsafi ◽  
B. Hultberg ◽  
A. Isaksson ◽  
Inga Hägerstrand ◽  
H. Prytz ◽  
...  
Keyword(s):  
Liver Disease ◽  
Human Liver ◽  
Immunohistochemical Study ◽  
Human Liver Disease

Platelet Aggregation and Platelet Lipid Composition in Human Liver Disease

1979 ◽  
Vol 56 (3) ◽  
pp. 14P-14P ◽  
Author(s):  
J. S. Owen ◽  
R. A. Hutton ◽  
R. C. Day ◽  
K. R. Bruckdorfer ◽  
N. McIntyre
Keyword(s):  
Liver Disease ◽  
Platelet Aggregation ◽  
Lipid Composition ◽  
Human Liver ◽  
Human Liver Disease
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