Functional, Electrophysiologic, and Morphometric Evaluation of Nerve Regeneration from Coaptation on Regenerated Nerve Fibers: Experimental Study in Rabbits

2004 ◽  
Vol 20 (2) ◽  
pp. 159-166 ◽  
Keyword(s):  
Experimental Study ◽  
Nerve Regeneration ◽  
Nerve Fibers ◽  
Morphometric Evaluation

scholarly journals White matter regeneration induced by aligned fibrin nanofiber hydrogel contributes to motor functional recovery in canine T12 spinal cord injury

2021 ◽  
Author(s):  
Zheng Cao ◽  
Weitao Man ◽  
Yuhui Xiong ◽  
Yi Guo ◽  
Shuhui Yang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
White Matter ◽  
Nerve Regeneration ◽  
Spinal Cord Injuries ◽  
Diffusion Tensor ◽  
Nerve Fibers ◽  
Functional Restoration ◽  
Large Animal ◽  
Cord Injury

Abstract A hierarchically aligned fibrin hydrogel (AFG) that possesses soft stiffness and aligned nanofiber structure has been successfully proven to facilitate neuroregeneration in vitro and in vivo. However, its potential in promoting nerve regeneration in large animal models that is critical for clinical translation has not been sufficiently specified. Here, the effects of AFG on directing neuroregeneration in canine hemisected T12 spinal cord injuries were explored. Histologically obvious white matter regeneration consisting of a large area of consecutive, compact, and aligned nerve fibers is induced by AFG, leading to a significant motor functional restoration. The canines with AFG implantation start to stand well with their defective legs from 3 to 4 weeks postoperatively and even effortlessly climb the steps from 7 to 8 weeks. Moreover, high-resolution multi-shot diffusion tensor imaging illustrates the spatiotemporal dynamics of nerve regeneration rapidly crossing the lesion within 4 weeks in the AFG group. Our findings indicate that AFG could be a potential therapeutic vehicle for spinal cord injury by inducing rapid white matter regeneration and restoring locomotion, pointing out its promising prospect in clinic practice.

Ciliary Neurotrophic Factor for Acceleration of Peripheral Nerve Regeneration: An Experimental Study

2004 ◽  
Vol 20 (04) ◽  
pp. 323-327 ◽  
Author(s):  
Jian Zhang ◽  
William Lineaweaver ◽  
Tanya Oswald ◽  
Zhengrong Chen ◽  
Zhongwei Chen ◽  
...  
Keyword(s):  
Experimental Study ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Neurotrophic Factor ◽  
Peripheral Nerve Regeneration ◽  
Ciliary Neurotrophic Factor

Influence of Suture on Peripheral Nerve Regeneration and Collagen Production at the Site of Neurorrhaphy: An Experimental Study

Neurosurgery ◽  
2011 ◽  
Vol 68 (3) ◽  
pp. 765-772 ◽  
Author(s):  
Roberto Sergio Martins ◽  
Walcy Rosolio Teodoro ◽  
Hougelle Simplício ◽  
Vera Luiza Capellozi ◽  
Mario Gilberto Siqueira ◽  
...  
Keyword(s):  
Experimental Study ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Collagen Production

EXPERIMENTAL STUDY OF THE REGENERATION OF SYMPATHETIC NERVE FIBERS AFTER NERVE HOMOGRAFTING

1974 ◽  
Vol 54 (6) ◽  
pp. 671-675 ◽  
Author(s):  
YASUSUKE HIRASAWA ◽  
RYONOSUKE ODA ◽  
KATSUYA NAKATANI ◽  
YOSHIAKI NOJYO
Keyword(s):  
Experimental Study ◽  
Sympathetic Nerve ◽  
Nerve Fibers ◽  
Sympathetic Nerve Fibers

Beneficial effect of nerve growth factor-7S on peripheral nerve regeneration through inside-out vein grafts: An experimental study

Microsurgery ◽  
2004 ◽  
Vol 24 (5) ◽  
pp. 408-415 ◽  
Author(s):  
Andreas I. Gravvanis ◽  
Dimosthenis A. Tsoutsos ◽  
George A. Tagaris ◽  
Apostolos E. Papalois ◽  
Charalampos G. Patralexis ◽  
...  
Keyword(s):  
Experimental Study ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Peripheral Nerve ◽  
Beneficial Effect ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Nerve Growth ◽  
Vein Grafts ◽  
Inside Out

Nerve Regeneration after Terminolateral Neurorrhaphy: Experimental Study in Rats

1997 ◽  
Vol 13 (01) ◽  
pp. 31-37 ◽  
Author(s):  
Jin-zhong Zhao ◽  
Zhong-wei Chen ◽  
Tong-yi Chen
Keyword(s):  
Experimental Study ◽  
Nerve Regeneration
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