Neuroprotective Effects of Bilobalide, a Component of Ginkgo biloba Extract (EGb 761®) in Global Brain Ischemia and in Excitotoxicity-induced Neuronal Death

2003 ◽  
Vol 36 ◽  
pp. 89-94 ◽  
Keyword(s):  
Brain Ischemia ◽  
Ginkgo Biloba ◽  
Neuronal Death ◽  
Ginkgo Biloba Extract ◽  
Egb 761 ◽  
Neuroprotective Effects ◽  
Global Brain Ischemia ◽  
Global Brain

Neuroprotective effects of bilobalide, a component of the Ginkgo biloba extract (EGb 761), in gerbil global brain ischemia

2001 ◽  
Vol 922 (2) ◽  
pp. 282-292 ◽  
Author(s):  
Krish Chandrasekaran ◽  
Zara Mehrabian ◽  
Brigitte Spinnewyn ◽  
Katy Drieu ◽  
Gary Fiskum
Keyword(s):  
Brain Ischemia ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Egb 761 ◽  
Neuroprotective Effects ◽  
Global Brain Ischemia ◽  
Global Brain

Neuroprotective effects of pterin-6-aldehyde in gerbil global brain ischemia: comparison with those of α-phenyl-N-tert-butyl nitrone

1998 ◽  
Vol 241 (2-3) ◽  
pp. 99-102 ◽  
Author(s):  
Hiroko Mori ◽  
Toshiyuki Arai ◽  
Hisanari Ishii ◽  
Takehiko Adachi ◽  
Nobuyuki Endo ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Neuroprotective Effects ◽  
Global Brain Ischemia ◽  
Tert Butyl ◽  
Global Brain

Abstract TP43: Transient Global Brain Ischemia Induces Striatal Neuronal Death of T1-Hyperintensity without Hemorrhage: Susceptibility-Weighted Imaging Study on Cardiac Arrest Survivors

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Masayuki Fujioka ◽  
Tomoo Watanabe ◽  
Toshiaki Taoka ◽  
Kazuo Okuchi
Keyword(s):  
Cardiac Arrest ◽  
Brain Ischemia ◽  
Neuronal Death ◽  
Late Onset ◽  
Global Brain Ischemia ◽  
Dorsolateral Striatum ◽  
Selective Neuronal Death ◽  
T1 Hyperintensity ◽  
Hemoglobin Degradation ◽  
Global Brain

Background: Global brain ischemia-reperfusion leads to selective neuronal death in the hippocampal CA1 area, cerebellar cortex, dorsolateral striatum, and/or neocortical layers 3, 5, and 6 in animal models and in humans. We have reported a delayed neurodegeneration of late-onset neuroimaging change in such brain areas vulnerable to ischemia (Stroke.1994;25:2091-95., Stroke.1999;30:1038-42., Stroke.1999;30:1043-46., Cerebrovasc Dis.2000;10:2-7., Ann Neurol.2003;54:732-7.). The magnetic resonance imaging (MRI) studies on patients after cardiac arrest showed 1) bilateral neurodegeneration with hyperintensity on T1-weighted MRI in the striatum, thalamus, and/or substantia nigra (Stroke.1994;25:2091-5., Neuroradiology.1994;36:605-7.), and 2) specific hippocampal atrophy in the chronic stage (MRI volumetry) (Cerebrovascular Dis.2000;10:2-7.). In the current study with susceptibility-weighted MRI (SWI), we investigated if the delayed T1-hyperintensity in the dorsolateral striatum consistently observed in cardiac arrest survivors represents minor hemorrhage (methemoglobin) or signifies selective neuronal death without bleeding reported as a specific type of ischemic neurodegeneration (Ann Neurol.2003;54:732-47.). Methods: We studied 11 patients in a vegetative state after unexpected out-of-hospital cardiac arrest who were able to undergo multiple brain MRI. We performed SWI to evaluate if the late-onset striatal T1-hyperintensity represents iron accumulation derived from hemoglobin degradation products or not. Results: In the 11 patients, serial MR images demonstrated delayed T1-hyperintesity in the bilateral striatum from one to two weeks after the onset. The SWI study showed no hypointense change in the striatal T1-hyperintensity. Conclusion: The striatal T1-hyperintensity after cardiac arrest seems to correspond to selective neuronal death and glial proliferation with paramagnetic effects but not hemoglobin degradation due to erythrocyte-extravasation.

Neuroprotective effects of Ginkgo biloba extract in brain ischemia are mediated by inhibition of nitric oxide synthesis

Life Sciences ◽  
2000 ◽  
Vol 67 (22) ◽  
pp. 2673-2683 ◽  
Author(s):  
Gioacchino Calapai ◽  
Anna Crupi ◽  
Fabio Firenzuoli ◽  
Maria C. Marciano ◽  
Francesco Squadrito ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Brain Ischemia ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Nitric Oxide Synthesis ◽  
Neuroprotective Effects

Possible Contribution of Proteins of Bcl-2 Family in Neuronal Death Following Transient Global Brain Ischemia

2014 ◽  
Vol 35 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Ivana Pilchova ◽  
Katarina Klacanova ◽  
Maria Chomova ◽  
Zuzana Tatarkova ◽  
Dusan Dobrota ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Neuronal Death ◽  
Global Brain Ischemia ◽  
Global Brain
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