Signet-ring Cell Carcinoma of unknown primary Location. Metastatic to lower back Musculature - Remission following FU/FA Chemotherapy

2002 ◽  
Vol 40 (1) ◽  
pp. 33-36 ◽  
Author(s):  
J Heidemann ◽  
H R Gockel ◽  
G Winde ◽  
H Herbst ◽  
W Domschke ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary ◽  
Lower Back ◽  
Signet Ring ◽  
Primary Location ◽  
Ring Cell

scholarly journals Testicular Signet-Ring Cell Metastasis from a Carcinoma of Unknown Primary Site: A Case Report and Literature Review

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Aristomenes Kollas ◽  
George Zarkavelis ◽  
Anna Goussia ◽  
Aikaterini Kafantari ◽  
Anna Batistatou ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Daily Practice ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Short Paper ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary ◽  
Signet Ring ◽  
Ring Cell ◽  
Testicular Metastases

Signet-ring cell carcinoma is a highly malignant adenocarcinoma consisting of cells characterized as cytoplasmic vacuoles filled with mucin. The most common primary location of this type of cancer is the stomach, but it may also be found in other organs such as prostate, testis, bladder, ovaries, or colon. To date, metastatic signet-ring cell carcinoma of unknown primary (CUP) site to the testis is an extremely rare entity in daily practice. Reviewing the literature, we have been able to detect only three cases of testicular metastases from CUP, two with histological diagnosis of a signet-ring cell carcinoma and one with an adenocarcinoma. In this short paper, we report a case of a 56-year-old man who presented to our Department with testicular mass and ascites. Following a standard diagnostic approach no primary tumor could be identified. CUP was the final clinical diagnosis, histologically characterized as poorly differentiated adenocarcinoma with signet-ring cells involving the peritoneum and the testicular structures.

scholarly journals Metastatic signet ring cell carcinoma of unknown primary source

2014 ◽  
Vol 2014 (feb17 1) ◽  
pp. bcr2013203407-bcr2013203407 ◽  
Author(s):  
D. O'Kane ◽  
K. Dean ◽  
R. Nightingale ◽  
S. Carlotto
Keyword(s):  
Cell Carcinoma ◽  
Primary Source ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary ◽  
Signet Ring ◽  
Ring Cell

Mediastinal signet-ring cell carcinoma of unknown primary: Long-term survival by treatment with S-1, a novel derivative of 5-fluorouracil

Lung Cancer ◽  
2007 ◽  
Vol 56 (1) ◽  
pp. 139-141 ◽  
Author(s):  
Chika Kusakari ◽  
Hiroshi Soda ◽  
Yoichi Nakamura ◽  
Hiroyuki Yamaguchi ◽  
Takeshi Kitazaki ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Unknown Primary ◽  
Term Survival ◽  
Long Term Survival ◽  
Carcinoma Of Unknown Primary ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Signet Ring Cell Carcinoma of Unknown Primary Complicated with Pulmonary Tumor Thrombotic Microangiopathy and Krukenberg Tumor

2018 ◽  
Vol 11 (2) ◽  
pp. 412-417
Author(s):  
Masahide Tanaka ◽  
Koichiro Takahashi ◽  
Yuki Kurihara ◽  
Mihoko Yamamoto-Rikitake ◽  
Shinsuke Ogusu ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Thrombotic Microangiopathy ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Unknown Primary ◽  
Krukenberg Tumor ◽  
Carcinoma Of Unknown Primary ◽  
Pulmonary Tumor ◽  
Signet Ring ◽  
Ring Cell

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare disease that shows hypoxia with severe pulmonary hypertension related to malignant tumor. Diagnosis is difficult due to rapid clinical progression and the need to demonstrate pathological findings from lung biopsy. A 64-year-old woman visited our hospital with hypoxia and pulmonary hypertension. Diffuse granular shadows in the centrilobular area and ground-glass shadows in both lungs and left ovarian tumor were found on radiological imaging. PTTM was suspected, but pulmonary artery blood aspiration by right cardiac catheter failed to detect cancer cells. We could not obtain lung or ovary biopsies because of hypoxia or pulmonary hypertension. The patient died due to respiratory failure. Signet ring cell carcinoma of unknown primary, PTTM, and Krukenberg tumor were diagnosed on autopsy. Since early diagnosis facilitates adequate treatment, physicians should not miss the opportunity for biopsy in cases of suspected PTTM.

scholarly journals A Case of Signet Ring Cell Carcinoma of Unknown Primary Origin Accompanied by Swollen Cervical Lymph Nodes

Haigan ◽  
2013 ◽  
Vol 53 (3) ◽  
pp. 259-263 ◽  
Author(s):  
Kotaro Kajiwara ◽  
Chizuru Hamada ◽  
Mayuko Semba ◽  
Naohiko Hamaguchi ◽  
Takanori Kanematsu ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Unknown Primary ◽  
Cervical Lymph Nodes ◽  
Carcinoma Of Unknown Primary ◽  
Signet Ring ◽  
Primary Origin ◽  
Ring Cell ◽  
Unknown Primary Origin

scholarly journals Signet Ring Cell Carcinoma of Unknown Primary Origin Detected Incidentally by Lymph Node Purification for Thyroid Carcinoma

2018 ◽  
Vol 57 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Hideo Handa ◽  
Daisuke Gomi ◽  
Toshirou Fukushima ◽  
Takashi Kobayashi ◽  
Nodoka Sekiguchi ◽  
...  
Keyword(s):  
Lymph Node ◽  
Thyroid Carcinoma ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary ◽  
Signet Ring ◽  
Primary Origin ◽  
Ring Cell ◽  
Unknown Primary Origin

Mucin Profiles in Signet-ring Cell Carcinoma

2006 ◽  
Vol 130 (6) ◽  
pp. 799-804 ◽  
Author(s):  
Minh D. Nguyen; ◽  
Brian Plasil ◽  
Ping Wen ◽  
Wendy L. Frankel
Keyword(s):  
Cell Carcinoma ◽  
Expression Patterns ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Unknown Primary ◽  
Cytoplasmic Staining ◽  
Mucin Expression ◽  
Signet Ring ◽  
Poorly Differentiated ◽  
Ring Cell

Abstract Context.—Signet-ring cell carcinoma (SRCC) is a poorly differentiated mucin-producing adenocarcinoma that may arise from many different organs, but all SRCCs share identical morphology. It is not possible to differentiate sites of origin for metastatic SRCC based on morphology alone. Mucins are high-molecular-weight glycoproteins differentially expressed in glandular epithelia and in adenocarcinomas. Objective.—To identify mucin profiles of primary and metastatic SRCCs using immunohistochemistry to determine whether mucin staining could help distinguish sites of origin. Design.—Forty-seven SRCCs, including 38 primary (21 stomach, 11 colorectum, and 6 breast) and 9 metastases from these primary sites were retrieved from archival files. Consecutive tissue sections were immunostained with monoclonal antibodies against MUC1, MUC2, MUC4, MUC5AC (MUC5), and MUC6 on separate slides. Cytoplasmic staining was scored based on proportion of positive tumor cells as follows: 0+ (<5%), 1+ (5%–25%), 2+ (26%–50%), and 3+ (>50%). Mucin profiles were recorded as MUC+, MUCv, and MUC− for consistent, variable, and negative expression, respectively. Results.—The mucin profiles for gastric, colorectum, and breast SRCCs are MUC1·2·4·5·6v, MUC2·4+/MUC5v/ MUC1·6−, and MUC1+/MUC2·5·6v/MUC4−, respectively. Mucin profiles of metastatic cases shared profiles with their respective primaries. Conclusions.—Signet-ring cell carcinomas of the stomach, colorectum, and breast have distinct mucin expression patterns that are maintained in metastases. Mucin profiling may be useful to identify the origin of a metastatic SRCC of unknown primary.

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