Gene therapy with sodium/iodide symporter in hepatocarcinoma

2001 ◽  
Vol 109 (01) ◽  
pp. 60-62 ◽  
Author(s):  
U. Haberkorn
Keyword(s):  
Gene Therapy ◽  
Sodium Iodide ◽  
Sodium Iodide Symporter

Systemic tumor-targeted sodium iodide symporter (NIS) gene therapy of hepatocellular carcinoma mediated by B6 peptide polyplexes

2017 ◽  
Vol 19 (5) ◽  
pp. e2957 ◽  
Author(s):  
Sarah Urnauer ◽  
Kathrin Klutz ◽  
Geoffrey K. Grünwald ◽  
Stephan Morys ◽  
Nathalie Schwenk ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Therapy ◽  
Sodium Iodide ◽  
Sodium Iodide Symporter ◽  
Nis Gene

scholarly journals GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo

2003 ◽  
Vol 8 (3) ◽  
pp. 508-518 ◽  
Author(s):  
Kenneth N Barton ◽  
Donald Tyson ◽  
Hans Stricker ◽  
Young S Lew ◽  
Gregory Heisey ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Therapy ◽  
Sodium Iodide ◽  
Noninvasive Imaging ◽  
Sodium Iodide Symporter ◽  
Gene Therapy Vectors

scholarly journals In vivo sodium iodide symporter gene therapy of prostate cancer

Gene Therapy ◽  
2001 ◽  
Vol 8 (20) ◽  
pp. 1524-1531 ◽  
Author(s):  
C Spitzweg ◽  
AB Dietz ◽  
MK O'Connor ◽  
ER Bergert ◽  
DJ Tindall ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gene Therapy ◽  
Sodium Iodide ◽  
Sodium Iodide Symporter

scholarly journals The sodium iodide symporter (NIS): novel applications for radionuclide imaging and treatment

2021 ◽  
Author(s):  
C Spitzweg ◽  
P J Nelson ◽  
E Wagner ◽  
P Bartenstein ◽  
W Weber ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Gene Delivery ◽  
Sodium Iodide ◽  
Genetically Engineered ◽  
Oncolytic Viruses ◽  
Sodium Iodide Symporter ◽  
Preclinical Development ◽  
Therapy Strategy ◽  
Nis Gene ◽  
Disseminated Disease

Cloning of the sodium iodide symporter (NIS) 25 years ago has opened an exciting chapter in molecular thyroidology with the characterization of NIS as one of the most powerful theranostic genes and the development of a promising gene therapy strategy based on image-guided selective NIS gene transfer in non-thyroidal tumors followed by application of 131I or alternative radionuclides, such as 188Re and 211At. Over the past 2 decades significant progress has been made in the development of the NIS gene therapy concept, from local NIS gene delivery, towards promising new applications in disseminated disease, in particular, through the use of oncolytic viruses, non-viral polyplexes, and genetically engineered MSCs as highly effective, highly selective and flexible gene delivery vehicles. In addition to allowing the robust therapeutic application of radioiodine in non-thyroid cancer settings, these studies have also been able to take advantage of NIS as a sensitive reporter gene that allows temporal and spatial monitoring of vector biodistribution, replication, and elimination - critically important issues for preclinical development and clinical translation.

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