Efficient Syntheses of Biologically Active Peptides of Aquatic Origin Involving Unusual Amino Acids

Synlett ◽  
2001 ◽  
Vol 2001 (02) ◽  
pp. 0184-0201 ◽  
Author(s):  
Takayuki Shioiri ◽  
Yasumasa Hamada
Keyword(s):  
Amino Acids ◽  
Biologically Active ◽  
Unusual Amino Acids ◽  
Active Peptides ◽  
Biologically Active Peptides

New Chemical Descriptors Relevant for the Design of Biologically Active Peptides. A Multivariate Characterization of 87 Amino Acids

1998 ◽  
Vol 41 (14) ◽  
pp. 2481-2491 ◽  
Author(s):  
Maria Sandberg ◽  
Lennart Eriksson ◽  
Jörgen Jonsson ◽  
Michael Sjöström ◽  
Svante Wold
Keyword(s):  
Amino Acids ◽  
Biologically Active ◽  
Active Peptides ◽  
Biologically Active Peptides ◽  
Chemical Descriptors

scholarly journals MALDI TOF/TOF-Based Approach for the Identification ofd- Amino Acids in Biologically Active Peptides and Proteins

2016 ◽  
Vol 15 (5) ◽  
pp. 1487-1496 ◽  
Author(s):  
Johannes Koehbach ◽  
Christian W. Gruber ◽  
Christian Becker ◽  
David P. Kreil ◽  
Alexander Jilek
Keyword(s):  
Amino Acids ◽  
Biologically Active ◽  
Active Peptides ◽  
Maldi Tof ◽  
Biologically Active Peptides

scholarly journals Design and synthesis of biologically active peptides: A ‘tail’ of amino acids can modulate activity of synthetic cyclic peptides

Peptides ◽  
2011 ◽  
Vol 32 (12) ◽  
pp. 2504-2510 ◽  
Author(s):  
Alberto Bryan ◽  
Leroy Joseph ◽  
James A. Bennett ◽  
Herbert I. Jacobson ◽  
Thomas T. Andersen
Keyword(s):  
Amino Acids ◽  
Cyclic Peptides ◽  
Biologically Active ◽  
Active Peptides ◽  
Design And Synthesis ◽  
Biologically Active Peptides

Chirale Erkennung von Naturstoffen an optisch aktiven Polysiloxanen Chiral Recognition of Natural Products on Optically Active Polysiloxanes

1983 ◽  
Vol 38 (10) ◽  
pp. 1281-1291 ◽  
Author(s):  
Ernst Bayer
Keyword(s):  
Amino Acids ◽  
Chiral Recognition ◽  
Stationary Phases ◽  
Temperature Stability ◽  
Biologically Active ◽  
Active Peptides ◽  
Biologically Active Peptides ◽  
Enantiomer Selectivity ◽  
Protein Amino Acids ◽  
Phosphorous Compounds

Abstract Polysiloxanes with chiral peptide side chains have been synthesized and used as stationary phases in gas chromatography. With these phases amino acid enantiomers can be separated as N-acyl esters. Due to temperature stability up to 230 °C all protein amino acids can be separated and the racemization of synthetic biologically active peptides controlled. The phases can be used to assign the absolute configuration of amino acids. A variety of other classes of compounds can be separated into their enantiomers using the chiral polysiloxanes, like hydroxy acids, sulfoxides, phosphorous compounds, glycols, atrop isomers, amines and alcohols. Various applications of these phases are described including investigations of enantiomer selectivity in nature.

scholarly journals The application of ketimine derivatives of amino acids to peptide synthesis

1976 ◽  
Vol 29 (7) ◽  
pp. 1591 ◽  
Author(s):  
AP Hope ◽  
B Halpern
Keyword(s):  
Amino Acids ◽  
Acetic Acid ◽  
Amino Acid ◽  
Biologically Active ◽  
Amino Acid Esters ◽  
Protecting Group ◽  
Active Peptides ◽  
Biologically Active Peptides ◽  
Derivatives Of ◽  
Acid Esters

N-(2-Hydroxyarylmethy1ene)amino acids have been coupled with amino acid esters to form sterically pure N-protected dipeptide esters. The protecting group can be removed by means of 80% acetic acid under conditions which leaves the t-butyloxycarbonyl protecting group intact. Biologically active peptides which are C-terminal partial sequences of substance P were prepared and were shown to have the expected vasodilator, spasmogenic and venoconstrictor properties.

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