Diarylheptanoids with In Vitro Inducible Nitric Oxide Synthesis Inhibitory Activity from Alnus hirsuta

Planta Medica ◽  
2000 ◽  
Vol 66 (6) ◽  
pp. 551-553 ◽  
Author(s):  
Min-Won Lee ◽  
Na-Young Kim ◽  
Myung-Shin Park ◽  
Kyoung-Hwan Ahn ◽  
Sang-Hak Toh ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Inhibitory Activity ◽  
Nitric Oxide Synthesis ◽  
Alnus Hirsuta ◽  
Inducible Nitric Oxide

In vitro modulation of inducible nitric oxide synthase gene expression and nitric oxide synthesis by procalcitonin

2001 ◽  
Vol 29 (1) ◽  
pp. 112-116 ◽  
Author(s):  
Georg Hoffmann ◽  
Gudrun Totzke ◽  
Maja Seibel ◽  
Michaela Smolny ◽  
Franz J. Wiedermann ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Nitric Oxide Synthesis ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

In Vitro Inducible Nitric Oxide Synthesis Inhibitors from Alismatis Rhizoma.

1999 ◽  
Vol 22 (10) ◽  
pp. 1147-1149 ◽  
Author(s):  
Na-Young KIM ◽  
Tai-Hyun KANG ◽  
Hyun-Ock PAE ◽  
Byung-Min CHOI ◽  
Hun-Taeg CHUNG ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthesis ◽  
Alismatis Rhizoma ◽  
Inducible Nitric Oxide

scholarly journals Effects of chitosan on nitric oxide production and inducible nitric oxide synthase activity and mRNA expression in weaned piglets

2018 ◽  
Vol 60 (No. 8) ◽  
pp. 359-366
Author(s):  
J. Li ◽  
B. Shi ◽  
S. Yan ◽  
L. Jin ◽  
Y. Guo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mrna Expression ◽  
Inducible Nitric Oxide Synthase ◽  
No Production ◽  
Weaned Piglets ◽  
Inos Activity ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

The effects of chitosan on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) activity and gene expression in vivo or vitro were investigated in weaned piglets. In vivo, 180 weaned piglets were assigned to five dietary treatments with six replicates. The piglets were fed on a basal diet supplemented with 0 (control), 100, 500, 1000, and 2000 mg chitosan/kg feed, respectively. In vitro, the peripheral blood mononuclear cells (PBMCs) from a weaned piglet were cultured respectively with 0 (control), 40, 80, 160, and 320 µg chitosan/ml medium. Results showed that serum NO concentrations on days 14 and 28 and iNOS activity on day 28 were quadratically improved with increasing chitosan dose (P < 0.05). The iNOS mRNA expressions were linearly or quadratically enhanced in the duodenum on day 28, and were improved quadratically in the jejunum on days 14 and 28 and in the ileum on day 28 (P < 0.01). In vitro, the NO concentrations, iNOS activity, and mRNA expression in unstimulated PBMCs were quadratically enhanced by chitosan, but the improvement of NO concentrations and iNOS activity by chitosan were markedly inhibited by N-(3-[aminomethyl] benzyl) acetamidine (1400w) (P < 0.05). Moreover, the increase of NO concentrations, iNOS activity, and mRNA expression in PBMCs induced by lipopolysaccharide (LPS) were suppressed significantly by chitosan (P < 0.05). The results indicated that the NO concentrations, iNOS activity, and mRNA expression in piglets were increased by feeding chitosan in a dose-dependent manner. In addition, chitosan improved the NO production in unstimulated PBMCs but inhibited its production in LPS-induced cells, which exerted bidirectional regulatory effects on the NO production via modulated iNOS activity and mRNA expression.

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