Body Weight Gain after Administration of Antipsychotic Drugs: Correlation with Leptin, Insulin and Reproductive hormones

2000 ◽  
Vol 33 (3) ◽  
pp. 81-88 ◽  
Author(s):  
T. Baptista ◽  
A. Lacruz ◽  
S. de Mendoza ◽  
J. M. MendozaGuillén ◽  
R. Silvera ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Antipsychotic Drugs ◽  
Body Weight Gain ◽  
Reproductive Hormones

scholarly journals Are Leptin and Cytokines Involved in Body Weight Gain during Treatment with Antipsychotic Drugs?

2002 ◽  
Vol 47 (8) ◽  
pp. 742-749 ◽  
Author(s):  
Trino Baptista ◽  
Serge Beaulieu
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Antipsychotic Drugs ◽  
Causal Relation ◽  
Body Weight Gain ◽  
Serum Insulin ◽  
Elevated Serum ◽  
Serum Levels ◽  
Metabolism Regulation ◽  
Tnf Α

Objective: To critically review published literature on the causal association between leptin, cytokines, and excessive body weight gain (BWG) induced by antipsychotic drugs (APs). Methods: We completed a Medline search using the words leptin, cytokines, antipsychotic drugs, neuroleptics, psychotropic drugs, weight gain, and obesity. We also included our empirical research on this topic in the discussion. We examined the relation between leptin, cytokines (mainly tumour necrosis factor alpha [TNF-α] and its soluble receptors), and AP-induced BWG, using the biological sciences' current theories of causality. Results: In the general field of weight regulation, there is scarce experimental evidence that leptin or TNF-α by themselves can induce obesity. Serum levels of leptin and TNF-α rather increase simultaneously as BWG occurs. This has also been reported during AP-induced BWG, with the equivocal exception of a study with clozapine. Some researchers have suggested that the absence of the expected correlation between leptin and body mass index (BMI) or serum insulin levels, and the lack of sex-related differences in leptin levels in AP-treated patients, may point to a causal relation. This contention requires more experimental support. In addition, future clinical studies must carefully control for sex and BMI. Conclusions: No conclusive evidence has been provided that leptin or TNF-α may induce obesity either in drug-free subjects or in AP-treated patients. In most cases, the elevated serum levels of these hormones appear to be a consequence rather than a cause of obesity. That does not mean that such an elevation is innocuous, since it may impair blood pressure and also carbohydrate and lipid metabolism regulation. Hence, all efforts should be made to prevent or attenuate BWG during treatment with APs.

Body Weight Gain after Administration of Antipsychotic Drugs

2002 ◽  
Vol 35 (1) ◽  
pp. 36-36 ◽  
Author(s):  
T. Baptista ◽  
A. Lacruz ◽  
D. De Mendoza ◽  
J. M. Mendoza ◽  
R. Silvera ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Antipsychotic Drugs ◽  
Body Weight Gain

scholarly journals Weight Gain, Schizophrenia and Antipsychotics: New Findings from Animal Model and Pharmacogenomic Studies

2011 ◽  
Vol 2011 ◽  
pp. 1-16 ◽  
Author(s):  
Fabio Panariello ◽  
Vincenzo De Luca ◽  
Andrea de Bartolomeis
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Animal Models ◽  
Candidate Genes ◽  
Antipsychotic Drugs ◽  
Body Weight Gain ◽  
Future Research ◽  
Excess Body Weight ◽  
Genetic Profile ◽  
New Findings

Excess body weight is one of the most common physical health problems among patients with schizophrenia that increases the risk for many medical problems, including type 2 diabetes mellitus, coronary heart disease, osteoarthritis, and hypertension, and accounts in part for 20% shorter life expectancy than in general population. Among patients with severe mental illness, obesity can be attributed to an unhealthy lifestyle, personal genetic profile, as well as the effects of psychotropic medications, above all antipsychotic drugs. Novel “atypical” antipsychotic drugs represent a substantial improvement on older “typical” drugs. However, clinical experience has shown that some, but not all, of these drugs can induce substantial weight gain. Animal models of antipsychotic-related weight gain and animal transgenic models of knockout or overexpressed genes of antipsychotic receptors have been largely evaluated by scientific community for changes in obesity-related gene expression or phenotypes. Moreover, pharmacogenomic approaches have allowed to detect more than 300 possible candidate genes for antipsychotics-induced body weight gain. In this paper, we summarize current thinking on: (1) the role of polymorphisms in several candidate genes, (2) the possible roles of various neurotransmitters and neuropeptides in this adverse drug reaction, and (3) the state of development of animal models in this matter. We also outline major areas for future research.

PENGEMBANGAN TANAMAN RAMI (Boehmeria nivea L. Gaud) DAN PEMANFAATAN LIMBAH DAUN RAMI UNTUK PENGGEMUKKAN DOMBA WONOSOBO

2018 ◽  
Vol 16 (2) ◽  
pp. 201-210
Author(s):  
Muryanto Muryanto ◽  
Pita Sudrajad ◽  
Amrih Prasetyo
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Plant Development ◽  
Body Weight Gain ◽  
Survey Methods ◽  
The Body ◽  
Boehmeria Nivea ◽  
Central Java ◽  
Potential Capacity ◽  
The Given

The aim of the study was to determine the development of ramie plants (Boehmeria nivea L. Gaud) and the effect of using ramie leaves on feed on the body weight gain of Wonosobo Sheep (Dombos). Research on the development of ramie plants using survey methods in the area of ramie plant development in Wonosobo Regency. While the research on the use of ramie leaves for fattening was carried out in Butuh Village, Kalikajar District, Wonosobo Regency in 2018. 21 male Dombos were divided into 3 feed treatments with forage proportions of 70%, 50% and 30 ramie leaves respectively. %. The results showed that currently ramie plants were being developed in Wonosobo Regency by CV. Ramindo Berkah Persada Sejahtera in Gandok Village, Kalikajar District, Wonosobo Regency, Central Java. Until now the area of the crop has reached 13 ha. Of this area will produce ramie leaves 195,000 kg / year. If one sheep needs 4 kg of ramie / tail / day leaves, then the potential capacity of sheep is 135 heads / year, if the given one is 50% then the Jurnal Litbang Provinsi Jawa Tengah, Volume 16 202 Nomor 2 – Desember 2018potential capacity is 270 heads / year and if it is reduced again to 25% of ramie leaves then the potential capacity 440 heads / year. The use of ramie leaves as a feed for Wonosobo Sheep fattening can be given as much as 30% in fresh form.

Eisenia bicyclis Inhibits Body Weight Gain and Fat Accumulation Induced by High-Fat Diets in Mice

2010 ◽  
Vol 15 (4) ◽  
pp. 262-266 ◽  
Author(s):  
Won-Hee Choi ◽  
Ji-Yun Ahn ◽  
Sun-A Kim ◽  
Tae-Wan Kim ◽  
Tae-Youl Ha
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
High Fat ◽  
Eisenia Bicyclis ◽  
Fat Accumulation ◽  
High Fat Diets ◽  
Fat Diets

Effect of Honey & Olive Oil Supplemented Bio-Yoghurt Feeding on Lipid Profile, Blood Glucose and Hematological Parameters in Rats

2019 ◽  
Vol 15 (2) ◽  
pp. 140-147
Author(s):  
Magdy M. Ismail ◽  
El-Tahra M. Ammar ◽  
Abd El-Wahab E. Khalil ◽  
Mohamed Z. Eid
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Blood Glucose ◽  
Olive Oil ◽  
Body Weight Gain ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

Background and Objective: Yoghurt, especially bio-yoghurt has long been recognized as a product with many health benefits for consumers. Also, honey and olive oil have considerable nutritional and health effects. So, the effect of administration of yoghurt made using ABT culture and fortified with honey (2 and 6%), olive oil (1 and 4%) or honey + olive oil (2+1 and 6+4% respectively) on some biological and hematological properties of rats was investigated.Methods:The body weight gain, serum lipid level, blood glucose level, serum creatinine level, Glutamic Oxaloacetic Transaminase (GOT) activity, Glutamic Pyruvic Transaminase (GPT) activity, leukocytes and lymphocytes counts of rats were evaluated.Results:Blending of bio-yoghurt with rats' diet improved body weight gain. Concentrations of Total plasma Cholesterol (TC), High-Density Lipoprotein cholesterol (HDL), Low-Density Lipoprotein cholesterol (LDL), Very Low-Density Lipoprotein cholesterol (VLDL) and Triglycerides (TG) significantly lowered in plasma of rats fed bio-yoghurt. Levels of TC, LDL, VLDL, and TG also decreased in rat groups feed bio-yoghurt supplemented with honey and olive oil. LDL concentrations were reduced by 10.32, 18.51, 34.17, 22.48, 43.30% in plasma of rats fed classic starter yoghurt, ABT yoghurt, ABT yoghurt contained 6% honey, ABT yoghurt contained 4% olive oil and ABT yoghurt contained 6% honey + 4% olive oil respectively. The blood glucose, serum creatinine, GOT and GPT values of rats decreased while white blood cells and lymphocytes counts increased by feeding bioyoghurt contained honey and olive oil.Conclusion:The findings enhanced the multiple therapeutic effects of bio-yoghurt supplemented with honey and olive oil.

Surgical Management of Atresia Ani in a Crossbred Calf

2019 ◽  
Vol 15 (02) ◽  
pp. 81-82
Author(s):  
Madan Pal ◽  
Kashi Ram ◽  
Chander Pal Garhwal ◽  
Virender .
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Present Report ◽  
Genetic Disorders ◽  
Economic Loss ◽  
Intestinal Atresia ◽  
Congenital Defect ◽  
Surgical Correction ◽  
Anal Opening

Atresia ani is a congenital defect that describes the absence of a normal anal opening. It is fatal unless a surgical correction is carried out to provide an anal opening. In female, the rectum may break through the vagina, forming a rectovaginal fistula permitting defecation via the vulva. Surgical treatment of atresia ani is indicated to save the animal’s life and to improve body weight gain. Intestinal atresia has been reported as a congenital defect in all species of domestic animals (Gass and Tibboel, 1980). Atresia ani may be caused by genetic disorders (chromosomes or transgenesis), environmental factors, or a combination of both (Cassini et al., 2005). Monsang et al. (2011) reported a case of double vulva with atresia ani in a crossbred calf. Atresia ani should be treated by a surgical operation to solve the problem, improve body weight gain, and reduce economic loss. The present report records a case of atresia ani in a crossbred cow-calf and its successful surgical correction.

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