Stereoisomers of a Simulant of the Nerve Agent Soman. Synthesis and Protein Conjugation

Synlett ◽  
2000 ◽  
Vol 12 (12) ◽  
pp. 1432-1434 ◽  
Author(s):  
Robert Moriarty ◽  
Anping Tao ◽  
Angelica Wendler ◽  
Om Prakash ◽  
Kaiming Liu ◽  
...  
Keyword(s):  
Nerve Agent ◽  
Protein Conjugation

Neurotrophin Expression in Nerve Agent VX-Exposed Rat Brain

2007 ◽  
Author(s):  
Santresda M. Johnson ◽  
Chris L. Robison ◽  
Tsung-Ming A. Shih ◽  
Lawrence Tong ◽  
Sarah Parylak ◽  
...  
Keyword(s):  
Rat Brain ◽  
Nerve Agent

The Role of DARPP-32, an Intracellular Signaling Molecule, in the Actions of the Nerve Agent Sarin

2005 ◽  
Author(s):  
Tsung-Ming Shih ◽  
Gretchen L. Snyder ◽  
Allen A. Fienberg ◽  
Stacey Galdi ◽  
Minal Rana ◽  
...  
Keyword(s):  
Intracellular Signaling ◽  
Nerve Agent ◽  
Signaling Molecule

Evaluation of ADD392124 for the Delayed Treatment of Nerve Agent-Induced Status Epilepticus Seizures

2011 ◽  
Author(s):  
John H. McDonough ◽  
Kerry E. Van Shura ◽  
Megan E. Lyman ◽  
Claire G. Eisner ◽  
Amelia Mazza ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Nerve Agent ◽  
Delayed Treatment

Fmoc Solid Phase Peptide Synthesis

1999 ◽  
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Peptide Chain ◽  
Standard Approach ◽  
Side Chain ◽  
Complex Structures ◽  
Protein Conjugation ◽  
Chemoselective Ligation ◽  
Routine Production

In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems outstanding at the time of publication of this earlier work have now been, for the most part, solved. As a result, innovators in the field have focussed their efforts to develop methodologies and chemistry for the synthesis of more complex structures. The focus of this new volume is much broader, and covers not only the essential procedures for the production of linear peptides but also more advanced techniques for preparing cyclic, side-chain modified, phospho- and glycopeptides. Many other methods also deserving attention have been included: convergent peptide synthesis; peptide-protein conjugation; chemoselective ligation; and chemoselective purification. The difficult preparation of cysteine and methionine-containing peptides is also covered, as well as methods for overcoming aggregation during peptide chain assembly and a survey of available automated instrumentation.

Efficacy of atropine and scopolamine on airway contractions following exposure to the nerve agent VX

2021 ◽  
Vol 419 ◽  
pp. 115512
Author(s):  
E. Wigenstam ◽  
E. Forsberg ◽  
A. Bucht ◽  
L. Thors
Keyword(s):  
Nerve Agent

Percutaneous exposure to the nerve agent VX: Efficacy of combined atropine, obidoxime and diazepam treatment

2010 ◽  
Vol 188 (1) ◽  
pp. 255-263 ◽  
Author(s):  
Marloes J.A. Joosen ◽  
Marcel J. van der Schans ◽  
Herman P.M. van Helden
Keyword(s):  
Nerve Agent ◽  
Percutaneous Exposure

Squaric ester amides as hydrolysis-resistant functional groups for protein-conjugation of RAFT-derived polymers

2016 ◽  
Vol 7 (47) ◽  
pp. 7242-7248 ◽  
Author(s):  
Zhiyue Zhang ◽  
Nane Vanparijs ◽  
Stef Vandewalle ◽  
Filip E. Du Prez ◽  
Lutz Nuhn ◽  
...  
Keyword(s):  
Functional Groups ◽  
Protein Conjugation ◽  
Reactive Polymers

We report on the synthesis of amine-reactive polymers, for the purpose of protein conjugation.

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