Development of Composition and Technologies of Dental Film with Ketorolac Trometamine

Drug Research ◽  
2020 ◽  
Author(s):  
Elena O. Bakhrushina ◽  
Natalia B. Demina ◽  
Alena S. Kashperko ◽  
Marina G. Vakina ◽  
Maria N. Anurova ◽  
...  
Keyword(s):  
Tensile Strength ◽  
Physicochemical Properties ◽  
Biodegradable Polymers ◽  
Phosphate Buffer ◽  
Dosage Form ◽  
Complex Matrix ◽  
Acrylic Polymer

AbstractThe report presents the results of the development of dental films with ketorolac trometamine based on the natural biodegradable polymers from the groups of sodium alginates and xanthan gums in combination with lightly crosslinked acrylic polymer carbopol. Physicochemical properties, such as moisture, mucoadhesion, thickness, tensile strength, disintegration in phosphate buffer were determined in obtained samples of this dosage form. A comparison of physicochemical properties of experimental samples and commercial model of dental film has allowed establishing the perspective composition of complex matrix of films with ketorolac trometamine for use in dentistry.

Three-Dimensional Microfabrication System for Biodegradable Microdevices With High-Resolution and Bio-Applicability

2005 ◽  
Author(s):  
Akira Yamada ◽  
Fuminori Niikura ◽  
Koji Ikuta
Keyword(s):  
Tensile Strength ◽  
Biodegradable Polymers ◽  
Conventional Method ◽  
Three Dimensional ◽  
Single Layer ◽  
Batch Process ◽  
Potential Applications ◽  
A Cell ◽  
The One ◽  
Almost All

Biodegradable polymers are employed in medicine and its further application is expected with eagerness. But the lack of an appropriate processing method retards the progress. To overcome this problem, we have developped a novel three-dimensional microfabrication system. The system design allows us the processing of the free three-dimensional micro-level forms by stacking up melted polymers from the nozzle. Different from the conventional method, we adopted a batch process to supply materials in order to eliminate the prior process that required toxic solvents. In addition, it is possible to handle almost all biodegradable thermoplastic resins by adopting this system. A single layer from the piled-up layers of extruded lines was observed to evaluate the resolution. The lateral and depth resolutions attained are 40 μm and 45 μm, respectively. Biodegradable polymers enable three-dimensional microstructures such as micro-pipes, micro-bends, and micro-coil springs to be manufactured in less than 15 min. The biocompatibility of the newly fabricated structure was evaluated using a cell line (PC12). For this purpose, a small vessel, with a transparent base, was fabricated using PLA and cells were cultivated in it. The results were then compared with the results obtained using the standard method. The mechanical strength of our microstructures was evaluated using a tensile strength test. The tensile strength of the microstructure was lower than the one obtained from the conventional method, but has enough strength for fabrication of medical devices. Our system renders it possible to produce toxic-free, as well as transparent and leakage-free devices. Our system is expected to have potential applications in optimum design and fabrication of implantable devices, especially in tissue engineering.

scholarly journals Development and validation of UV spectroscopic methods for simultaneous estimation of ciprofloxacin and tinidazole in tablet formulation

2012 ◽  
Vol 1 (10) ◽  
pp. 317-321 ◽  
Author(s):  
Sowjanya Gummadi ◽  
Devi Thota ◽  
Sri Valli Varri ◽  
Pratyusha Vaddi ◽  
Venkata Lakshmi Narasimha Seshagiri Rao
Keyword(s):  
Phosphate Buffer ◽  
Dosage Form ◽  
Pharmaceutical Journal ◽  
Simultaneous Equations ◽  
Simultaneous Estimation ◽  
Spectroscopic Methods ◽  
Good Reproducibility ◽  
Statistical Validation ◽  
Development And Validation ◽  
Tablet Dosage

Two simple, accurate, precise, reproducible and economical UV spectroscopic methods (A &  B) for simultaneous estimation of Ciprofloxacin and Tinidazole in tablet dosage form have been developed. Method A employs solving of simultaneous equations based on the measurement of absorbance at two wavelengths, 271nm and 318nm which are the ?max values of Ciprofloxacin and Tinidazole respectively in phosphate buffer (pH 6.8). Method B is based on the principle of  Q-Analysis where in the absorbance was measured at 292nm (iso-absorptive point) and 271nm (?max of Ciprofloxacin)in phosphate buffer (pH 6.8). Ciprofloxacin and Tinidazole  shows linearity at all the selected wave-lengths and  obeys Beer’s law in the concentration range of 10-35µg/mL and 10-80µg/mL respectively.  Recovery studies for Ciprofloxacin and Tinidazole were performed and the percentage recovery for both the drugs was obtained in the range of 98.1-99.7% (Method A) and 98.0-100.4% (Method B) confirming the accuracy of the proposed method. Both the methods showed good reproducibility and recovery with %RSD less than 2. Statistical validation of the data shows that the proposed methods can be successfully applied for the routine analysis of drugs in commercial tablets.DOI: http://dx.doi.org/10.3329/icpj.v1i10.11849 International Current Pharmaceutical Journal 2012, 1(10): 317-321 

scholarly journals Optimasi Fase Gerak Kromatografi Cair Kinerja Tinggi Pada Penetapan Kadar Parasetamol, Gliseril Guaiakolat, Klorfeniramin Maleat, dan Fenilefrin Hcl Dalam Sediaan Tablet Secara Simultan

2018 ◽  
Vol 1 (1) ◽  
pp. 224-229
Author(s):  
Ellora Ellora ◽  
Effendy De Lux Putra ◽  
Ginda Haro
Keyword(s):  
United States ◽  
Phosphate Buffer ◽  
Mobile Phase ◽  
Dosage Form ◽  
Fixed Combination ◽  
The United States ◽  
Chlorpheniramine Maleate ◽  
United States Pharmacopoeia ◽  
Phenylephrine Hydrochloride ◽  
Active Substances

Di pasaran, terdapat berbagai sediaan obat yang mengkombinasikan dua atau lebih zat aktif dalam satu sediaan, salah satunya adalah obat flu yang mengandung parasetamol, klorfeniramin maleat, gliseril guaiakolat dan fenilefrin hidroklorida. Penelitian ini bertujuan untuk menetapkan kadar keempat campuran zat aktif tersebut secara simultan karena analisis keempat campuran zat aktif tersebut belum ditemukan baik di Farmakope Indonesia maupun di United States Pharmacopoeia. Penelitian dilakukan dengan mengoptimasi berbagai jenis campuran fase gerak yaitu metanol dengan buffer fosfat pH 4,1; metanol dengan buffer fosfat pH 4,3 dan metanol dengan buffer fosfat pH 4,6. Selain itu juga dilakukan optimasi berbagai perbandingan fase gerak yaitu 30:70; 40:60; 50:50; 60:40 dan 70:30. Hasil penelitian menunjukkan bahwa kombinasi fase gerak metanol:buffer fosfat pH 4,3 dengan perbandingan fase gerak 60:40; laju alir 1 ml/menit dan dideteksi pada panjang gelombang 263 nm dapat digunakan untuk menetapkan kadar parasetamol, klorfeniramin maleat, gliseril guaiakolat dan fenilefrin hidroklorida secara KCKT. Hasil kadar pada sediaan tablet Supraflu® memenuhi persyaratan yaitu diperoleh kadar fenilefrin HCl, parasetamol, gliseril guaiakolat dan klorfeniramin maleat berturutturut adalah 99,2362% ± 0,4493%; 96,0242% ± 0,2180%; 97,9870% ± 0,7435% dan 101.4191% ± 0,7106%. There are numerous drug preparations that consist two or more active substances in a fixed combination dosage form . One of them is flu remedies containing paracetamol, chlorpheniramine maleate, glycerylguaiacolate, and phenylephrine hydrochloride. This study aimed to determine the levels of the four mixtures of active substances simultaneously because the analysis of the four mixtures of active substances had not been found either in Indonesian Pharmacopoeia or in the United States Pharmacopoeia. The study was conducted by optimizing various types of mobile phase mixtures, i.e. methanol-phosphate buffer at pH 4.1, methanol- phosphate buffer at pH 4.3, and methanol-phosphate buffer at pH 4.6. Besides that, optimization of various mobilephase ratios were also conducted, i.e. 30:70; 40:60; 50:50; 60:40 and 70:30. The results showed that the mobilephase combination of methanol-phosphate buffer at pH 4.3 with a mobilephase ratio of 60:40; flow rate of 1 ml/minute and detection wavelength at 263 nm could be used to determine the levels of paracetamol, chlorpheniramine maleate, glycerylguaiacolate, and phenylephrine hydrochloride using HPLC. The results of the levels in Supraflu® tablet preparations met the requirements, where levels of phenylephrine HCl, paracetamol, glycerylguaiacolate and chlorpheniraminemaleate   were 99.2362% ± 0.4493%; 96,0242% ± 0,2180%; 97.9870% ± 0.7435% and 101.4191% ± 0.7106%, respectively.

scholarly journals Preformulation Studies of Pralidoxime Chloride for Formulation Development of Microspheres

2019 ◽  
Vol 9 (4-s) ◽  
pp. 338-342
Author(s):  
Shyam Bihari Sharma ◽  
Suman Jain ◽  
K. Ganesan
Keyword(s):  
Melting Point ◽  
Physicochemical Properties ◽  
Dosage Form ◽  
Chemical Parameter ◽  
New Drug ◽  
Physico Chemical ◽  
Pralidoxime Chloride ◽  
Preformulation Studies ◽  
Preformulation Study ◽  
Excipient Compatibility

Microspheres are one of the novel drug delivery system which possess several applications and are made up of assorted polymers. Microspheres can be defined as solid, approximately spherical particles ranging in size from 1 to 1000 μm range in diameter having a core of drug and entirely outer layers of polymers as coating material. They are made up of polymeric, waxy or other protective materials i.e. biodegradable synthetic polymer and modified natural products such as starches, gums, proteins, fats and waxes. Preformulation is a group of studies that focus on the physicochemical properties of a new drug candidate that could affect the drug performance and the development of a dosage form. This couldprovide important information for formulation design or support the need for molecular modification. Every drug has intrinsic chemical and physical properties which has been consider before development of pharmaceutical formulation. This property provides the framework for drugs combination with pharmaceutical ingredients in the fabrication of dosage form. Objective of preformulation study is to develop the elegant, stable, effective and safe dosage form by establishing kinetic rate profile, compatibility with the other ingredients and establish Physico-chemical parameter of new drug substances. The purpose of the present study was to systematically investigate some of the important physicochemical properties of pralidoxime chloride for preparation of microspheres. The physicochemical properties such as solubility, pKa, dissolution, melting point, assay development, excipient compatibility etc. of pralidoxime chloride was carried out. Before selection of excipients, the Preformulation study of drug pralidoxime is completed for successful formulation of microspheres. The result of Preformulation studies shows good flow properties, excipient compatibility, solubility efficiency and melting point. From this study we concluded that pralidoximewith HPMC and EC can be used to formulate pralidoxime microspheres for modified release. Keywords: Microspheres, Preformulation, Pralidoxime chloride, Physico-chemical parameter.

scholarly journals Research Regarding the Mechanical Properties of Some Biodegradable Polymeric Composites for Food Packaging Products

2018 ◽  
Vol 55 (4) ◽  
pp. 498-501
Author(s):  
Constantin Gheorghe Opran ◽  
Elena Grosu ◽  
Marius Enachescu
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Injection Molding ◽  
Biodegradable Polymers ◽  
Food Packaging ◽  
Young Modulus ◽  
Important Application ◽  
Elongation At Break ◽  
Amorphous Character ◽  
Sem Analyses

Biodegradable polymers became one of the most important materials with large applicability, as they do not generate wastes after life cycle. An important application is food packaging fabricated by injection molding processing. In this paper, we present the investigation of the mechanical properties of some biodegradable polymers based on PLA composites obtained by melting processing and their morphology studied by SEM analyses, in comparison to polypropylene and neat PLA. We found out that tensile strength, elongation at break and Young modulus exhibit values appropriate to injection molding processing and they are very close related to crystalline or amorphous character of the materials.

scholarly journals Hydrophilic Films Based on Carboxymethylated Derivatives of Starch and Cellulose

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2447
Author(s):  
Katarzyna Wilpiszewska ◽  
Adrian Krzysztof Antosik ◽  
Beata Schmidt ◽  
Jolanta Janik ◽  
Joanna Rokicka
Keyword(s):  
Surface Roughness ◽  
Tensile Strength ◽  
Thermal Properties ◽  
Physicochemical Properties ◽  
Moisture Absorption ◽  
Weight Ratio ◽  
Mechanical And Thermal Properties ◽  
Film Preparation ◽  
Polysaccharide Derivatives ◽  
Derivatives Of

The carboxymethylated derivatives of starch (CMS) and cellulose (CMC) were used for film preparation. The infrared spectroscopy revealed that crosslinking via ester bridges with citric acid occurred between the two polysaccharide derivatives. The effect of polysaccharide derivatives ratio on physicochemical properties of prepared films was evaluated. Generally, the values of tested parameters (moisture absorption, surface roughness, and mechanical and thermal properties) were between the values noted for neat CMS or CMC-based films. However, the physicochemical properties of the system with equal CMS/CMC weight ratio diverged from this trend, i.e., the highest tensile strength, the highest Young’s modulus (ca. 3.4 MPa and ca. 4.9 MPa, respectively), with simultaneously the lowest moisture absorption (18.5% after 72 h) have been noted. Such systems could potentially find application in agriculture or pharmacy.

Effect of Physicochemical Properties of Biodegradable Polymers on Nano Drug Delivery

2013 ◽  
Vol 53 (4) ◽  
pp. 546-567 ◽  
Author(s):  
Sonam ◽  
Hema Chaudhary ◽  
Vimal Arora ◽  
Kanchan Kholi ◽  
Vikash Kumar
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Biodegradable Polymers ◽  
Nano Drug Delivery
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